Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Tina L. Sumpter"'
Autor:
Stephen C. Balmert, Zohreh Gholizadeh Ghozloujeh, Cara Donahue Carey, Li’an H. Williams, Jiying Zhang, Preeti Shahi, Maher Amer, Tina L. Sumpter, Geza Erdos, Emrullah Korkmaz, Louis D. Falo, Jr.
Publikováno v:
iScience, Vol 25, Iss 10, Pp 105045- (2022)
Summary: Sustainable global immunization campaigns against COVID-19 and other emerging infectious diseases require effective, broadly deployable vaccines. Here, we report a dissolvable microarray patch (MAP) SARS-CoV-2 vaccine that targets the immuno
Externí odkaz:
https://doaj.org/article/ecf940f82be949dab711a9d7dd51cc64
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
The purinergic receptor P2X7 (P2X7R) is important in inflammasome activation and generally considered to favor proinflammatory immune responses. However, there is still a limited understanding of the role of P2X7R signaling in Th cell differentiation
Externí odkaz:
https://doaj.org/article/f00f21a4df0d44979b280632f397a209
Autor:
Peng Wang, Meaghan E. Killeen, Tina L. Sumpter, Laura K. Ferris, Louis D. Falo, Jr., Bruce A. Freeman, Francisco J. Schopfer, Alicia R. Mathers
Publikováno v:
Redox Biology, Vol 43, Iss , Pp 101987- (2021)
Psoriasis is a chronic inflammatory skin disease with no cure. Although the origin of psoriasis and its underlying pathophysiology remain incompletely understood, inflammation is a central mediator of disease progression. In this regard, electrophili
Externí odkaz:
https://doaj.org/article/4b0d7cf207144e3e87124caa4fa7109b
Autor:
Adrian E. Morelli, Tina L. Sumpter, Darling M. Rojas-Canales, Mohna Bandyopadhyay, Zhizhao Chen, Olga Tkacheva, William J. Shufesky, Callen T. Wallace, Simon C. Watkins, Alexandra Berger, Christopher J. Paige, Louis D. Falo, Jr., Adriana T. Larregina
Publikováno v:
Cell Reports, Vol 30, Iss 10, Pp 3448-3465.e8 (2020)
Summary: Efficient Ca2+ flux induced during cognate T cell activation requires signaling the T cell receptor (TCR) and unidentified G-protein-coupled receptors (GPCRs). T cells express the neurokinin-1 receptor (NK1R), a GPCR that mediates Ca2+ flux
Externí odkaz:
https://doaj.org/article/8754f15be35f40a1af5f7a3af7cdad07
Publikováno v:
Journal of Allergy and Clinical Immunology. 151:1169-1177
Publikováno v:
Journal of Investigative Dermatology. 142:841-848
Skin-resident mast cells (MCs) and cutaneous sensory neurons both play crucial roles in microbial‒host defense and inflammatory diseases. MCs can be directly activated by pathogens or their products, resulting in the release of numerous mediators t
Autor:
Tina L. Sumpter, Stephen C. Balmert, Cara Donahue Carey, Emrullah Korkmaz, Geza Erdos, Louis D. Falo
Publikováno v:
Advanced Drug Delivery Reviews
Advanced drug delivery reviews, 171:164-186
Advanced drug delivery reviews, 171:164-186
The COVID-19 pandemic is a serious threat to global health and the global economy. The ongoing race to develop a safe and efficacious vaccine to prevent infection by SARS-CoV-2, the causative agent for COVID-19, highlights the importance of vaccinati
Autor:
Linda M. McAllister-Lucas, Tina L. Sumpter, Kevin Foley, Danielle N. Alfano, Peter J. Gough, John Bertin, Peter C. Lucas, Linda R. Klei, Matthew Trotta, Hanna B. Klei
Publikováno v:
The Journal of Immunology. 204:2337-2348
The signaling protein MALT1 plays a key role in promoting NF-κB activation in Ag-stimulated lymphocytes. In this capacity, MALT1 has two functions, acting as a scaffolding protein and as a substrate-specific protease. MALT1 is also required for NF-
Autor:
Mohna Bandyopadhyay, Adrian E. Morelli, Stephen C. Balmert, Nicole L. Ward, Geza Erdos, Tina L. Sumpter, Emrullah Korkmaz, Daniel H. Kaplan, Martin H. Oberbarnscheidt, Olga Tkacheva, William J. Shufesky, Louis D. Falo, Adriana T. Larregina
Publikováno v:
J Allergy Clin Immunol
BACKGROUND: Allergic contact dermatitis (CD) is a chronic inflammatory skin disease caused by type-1 biased adaptive immunity for which there is an unmet need for antigen (Ag)-specific immunotherapies. Exposure to skin sensitizers stimulates secretio
Publikováno v:
Frontiers in cell and developmental biology. 10
The purinergic receptor P2X7 (P2X7R) is important in inflammasome activation and generally considered to favor proinflammatory immune responses. However, there is still a limited understanding of the role of P2X7R signaling in Th cell differentiation