Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Tina L Hamilton"'
Autor:
David G Kent, Juan Li, Hinal Tanna, Juergen Fink, Kristina Kirschner, Dean C Pask, Yvonne Silber, Tina L Hamilton, Rachel Sneade, Benjamin D Simons, Anthony R Green
Publikováno v:
PLoS Biology, Vol 11, Iss 6, p e1001576 (2013)
Recent descriptions of significant heterogeneity in normal stem cells and cancers have altered our understanding of tumorigenesis, emphasizing the need to understand how single stem cells are subverted to cause tumors. Human myeloproliferative neopla
Externí odkaz:
https://doaj.org/article/7dfd3a5ed19c436ab9d0cf6c7ee2e024
Autor:
Kristina Kirschner, Tamir Chandra, Vladimir Kiselev, David Flores-Santa Cruz, Iain C. Macaulay, Hyun Jun Park, Juan Li, David G. Kent, Rupa Kumar, Dean C. Pask, Tina L. Hamilton, Martin Hemberg, Wolf Reik, Anthony R. Green
Publikováno v:
Cell Reports, Vol 19, Iss 8, Pp 1503-1511 (2017)
Aging of the hematopoietic stem cell (HSC) compartment is characterized by lineage bias and reduced stem cell function, the molecular basis of which is largely unknown. Using single-cell transcriptomics, we identified a distinct subpopulation of old
Externí odkaz:
https://doaj.org/article/8b76b64798534b639419288a43fe51f3
Autor:
Juan Li, Matthew J. Williams, Hyun Jung Park, Hugo P. Bastos, Xiaonan Wang, Daniel Prins, Nicola K. Wilson, Carys Johnson, Kendig Sham, Michelle Wantoch, Sam Watcham, Sarah J. Kinston, Dean C. Pask, Tina L. Hamilton, Rachel Sneade, Amie K. Waller, Cedric Ghevaert, George S. Vassiliou, Elisa Laurenti, David G. Kent, Berthold Göttgens, Anthony R. Green
Publikováno v:
Blood. 140(14)
Adult hematopoietic stem cells (HSCs) are predominantly quiescent and can be activated in response to acute stress such as infection or cytotoxic insults. STAT1 is a pivotal downstream mediator of interferon (IFN) signaling and is required for IFN-in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0b3473e03ba7545c979340a928a1812
https://pubmed.ncbi.nlm.nih.gov/35767701
https://pubmed.ncbi.nlm.nih.gov/35767701
Autor:
Mairi Shepherd, Dean C. Pask, Caroline A. Oedekoven, Anjana Rao, Juergen Fink, Anthony R. Green, Juan Li, David G. Kent, Nicola K. Wilson, Tina L. Hamilton, Jiangbing Li, Miriam Belmonte, Timm Schröder, Dirk Loeffler, Janine C. M. Prick, Berthold Göttgens
Recent advances in single-cell technologies have permitted the investigation of heterogeneous cell populations at previously unattainable resolution. Here we apply such approaches to resolve the molecular mechanisms driving disease in mouse hematopoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354e0bd77ab3f548f5b6a0719fa7b2a7
https://europepmc.org/articles/PMC6107881/
https://europepmc.org/articles/PMC6107881/
Autor:
Daniel Prins, Dean C. Pask, Cavan Bennett, Rachel Sneade, Tina L. Hamilton, Anthony R. Green, Jacob Grinfeld, Stephen J. Loughran, Carlos Gonzalez-Arias, David G. Kent, George S. Vassiliou, Oliver M. Dovey, Cedric Ghevaert, Thorsten Klampfl, Juliet Aungier, Juan Li, Matthew Williams, Hyun Jung Park
Publikováno v:
Blood. 131(6)
Somatic mutations in the endoplasmic reticulum chaperone calreticulin (CALR) are detected in approximately 40% of patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF). Multiple different mutations have been reported, but all r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f540cc96bc68a704184e4df59bf745
https://pubmed.ncbi.nlm.nih.gov/29282219
https://pubmed.ncbi.nlm.nih.gov/29282219
Autor:
Juan Li, David G. Kent, Anna L. Godfrey, Anthony R. Green, Pentao Liu, Dean C. Pask, Juergen Fink, Jyoti Nangalia, Athar Aziz, Xiaodong Zhao, Harriet Manning, Cedric Ghevaert, Edwin Chen, Yvonne Silber, Rachel Sneade, Tina L. Hamilton, Kourosh Saeb-Parsy
Publikováno v:
Blood. 123:3139-3151
Genomic regions of acquired uniparental disomy (UPD) are common in malignancy and frequently harbor mutated oncogenes. Homozygosity for such gain-of-function mutations is thought to modulate tumor phenotype, but direct evidence has been elusive. Poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fc0182ae9b198c7e8b60737a036bc21
https://doi.org/10.1182/blood-2013-06-510222
https://doi.org/10.1182/blood-2013-06-510222
The LMO2 gene is involved in T-cell acute leukaemia (T-ALL) in children with chromosomal translocations t(11;14)(p13;q11) or (7;11)(q35;p13). Transgenic expression of Lmo2 in T cells results in clonal tumours with long latency indicating that mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b0d9636d0a3fb8667b9536a3515192
https://ora.ox.ac.uk/objects/uuid:43d11543-d7d5-4a11-a122-cb0ea7a1281c
https://ora.ox.ac.uk/objects/uuid:43d11543-d7d5-4a11-a122-cb0ea7a1281c
Autor:
Hinal Tanna, Dean C. Pask, Benjamin D. Simons, Juergen Fink, Kristina Kirschner, Yvonne Silber, Rachel Sneade, Tina L. Hamilton, David G. Kent, Anthony R. Green, Juan Li
Publikováno v:
PLoS Biology
PLoS Biology, Vol 11, Iss 6, p e1001576 (2013)
PLoS Biology, Vol 11, Iss 6, p e1001576 (2013)
In this study, single cell assays and mathematical modeling demonstrate that a single oncogenic point mutation can negatively affect hematopoietic stem cells while leaving progenitor cell expansion intact.
Recent descriptions of significant hete
Recent descriptions of significant hete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc74fa06092a47f8cf531260547a37d
http://europepmc.org/articles/PMC3672217
http://europepmc.org/articles/PMC3672217
Autor:
Georges Lacaud, Josette-Renee Landry, Nicola K. Wilson, Valerie Kouskoff, Kathy Knezevic, Berthold Göttgens, Michelle Hammett, George A. Follows, Sarah Kinston, Jonathan Frampton, Nicolas Bonadies, Sandie Piltz, Jacinta Carter, Ian J. Donaldson, Mary E. Janes, Tina L. Hamilton, S. Helen Oram
Publikováno v:
Blood. 113(23)
The Lmo2 gene encodes a transcriptional cofactor critical for the development of hematopoietic stem cells. Ectopic LMO2 expression causes leukemia in T-cell acute lymphoblastic leukemia (T-ALL) patients and severe combined immunodeficiency patients u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8444f01584c41ee3a0e400619b7d6476
https://pubmed.ncbi.nlm.nih.gov/19498023
https://pubmed.ncbi.nlm.nih.gov/19498023