Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Tina K. Machu"'
Autor:
Tina K. Machu
Publikováno v:
Pharmacology & Therapeutics. 130:338-347
The 5-Hydroxytryptamine3 (5-HT3) receptor is a member of the cys-loop family of ligand gated ion channels, of which the nicotinic acetylcholine receptor is the prototype. All other 5-HT receptors identified to date are metabotropic receptors. The 5-H
Autor:
Xiaofei Wen, Dong Yan, Heather E. Rhubottom, Tina K. Machu, Ran Zhang, Nancy J. Leidenheimer, Brent Hester, Hongwei Sun, Julius Militante, Michael M. White
Publikováno v:
Biochemistry. 46:1194-1204
The competitive antagonist d-tubocurarine (curare) has greater potency at mouse than at human 5-hydroxytryptamine 3A (5-HT3A) receptors, despite 84% amino acid sequence identity between the receptors. Within the ligand binding domain of this receptor
Autor:
Heather E. Rhubottom, Tina K. Machu, Volodya Hayrapetyan, Xiang Qun Hu, David M. Lovinger, Jay J. Gadhiya
Publikováno v:
British Journal of Pharmacology. 148:88-101
1 The goal of this study was to determine whether mutations of L293 at the 15' position of TM2 in the 5-HT(3A) receptor alter macroscopic current kinetics, and if these changes could account for alterations in alcohol modulation. Receptor function wa
Publikováno v:
Brain Research. 1086:1-8
Amphibian oocyte and mammalian heterologous expression systems are often used to investigate the function of recombinant ion channels using electrophysiological techniques. Although both systems have yielded important information, the results obtaine
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 317:1276-1284
The present study tested the hypothesis that mouse and human 5-hydroxytryptamine3A (5-HT3A) receptors may be differentially modulated by benzylidene analogs of anabaseine (BA) and that these analogs may be useful in assessing residues involved in rec
Autor:
Tina K. Machu, Volodya Hayrapetyan, Cheng Xiao, Hui Sun, Sacha T. Kuo, Liana Asatryan, Li Zhang, Xiang Qun Hu, Jiang-Hong Ye, Ronald L. Alkana, John J. Woodward, Brian F. King, Daryl L. Davies, David M. Lovinger
Publikováno v:
Alcoholism: Clinical and Experimental Research. 30:349-358
This report of the proceedings of a symposium presented at the 2005 annual meeting of the Research Society on Alcoholism highlights the actions of ethanol on purinergic (P2XRs) and 5-hydro-xytryptamine3 (5-HT3Rs) receptors. Both P2XRs and 5-HT3Rs, ar
Autor:
David M. Lovinger, James M. Murphy, Bankole A. Johnson, Richard J. Thielen, Tina K. Machu, Zachary A. Rodd, John D. Roache, William J. McBride
Publikováno v:
Alcoholism: Clinical & Experimental Research. 28:257-267
This article represents the proceedings of a symposium at the 2003 annual meeting of the Research Society on Alcoholism in Fort Lauderdale, FL. The organizers and chairs were William J. McBride and David M. Lovinger. The presentations were (1) Mechan
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 306:595-604
Mutant 5-hydroxytryptamine (5-HT) 3A receptors, in which changes were made at Ile294, position 16′, of the second transmembrane domain, were assessed for alterations in macroscopic response kinetics and modulation by alcohols. Function of heterolog
Publikováno v:
Alcoholism: Clinical and Experimental Research. 26:773-778
Background: P2X receptors are ligand-gated cation channels that are gated by synaptically released extracellular adenosine 5'-triphosphate (ATP). P2X receptors are inhibited by ethanol; however, few investigations have focused on ethanol's effects in
Autor:
Tina K. Machu, Steven J. Coultrap
Publikováno v:
Receptors and Channels. 8:63-70
The effects of phorbol 12-myristate, 13-acetate (PMA) on 5-hydroxytryptamine (5-HT)-evoked ion currents in the mouse 5-HT 3A receptor were examined. Perfusion with PMA caused a concentration dependent potentiation of 5-HT mediated currents and increa