Nanoscopical Analysis Reveals an Orderly Arrangement of the Presynaptic Scaffold Protein Bassoon at the Golgi-Apparatus

Autor: Tina Ghelani, Carolina Montenegro-Venegas, Anna Fejtova, Thomas Dresbach

Publikováno v: Frontiers in Molecular Neuroscience, Vol 14 (2021)

Bassoon is a core scaffold protein of the presynaptic active zone. In brain synapses, the C-terminus of Bassoon is oriented toward the plasma membrane and its N-terminus is oriented toward synaptic vesicles. At the Golgi-apparatus, Bassoon is thought

Externí odkaz: https://doaj.org/article/293f35936d2f4672a52f113d0883329e

Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca2+ channels drives sustained active zone potentiation

Autor: Tina Ghelani, Marc Escher, Ulrich Thomas, Klara Esch, Janine Lützkendorf, Harald Depner, Marta Maglione, Pierre Parutto, Scott Gratz, Tanja Matkovic-Rachid, Stefanie Ryglewski, Alexander M. Walter, David Holcman, Kate O‘Connor Giles, Martin Heine, Stephan J. Sigrist

Publikováno v: Ghelani, T, Escher, M, Thomas, U, Esch, K, Lützkendorf, J, Depner, H, Maglione, M, Parutto, P, Gratz, S, Matkovic-Rachid, T, Ryglewski, S, Walter, A M, Holcman, D, O'Connor Giles, K, Heine, M & Sigrist, S J 2023, ' Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca 2+ channels drives sustained active zone potentiation ', Science Advances, vol. 9, no. 7, eade7804 . https://doi.org/10.1126/sciadv.ade7804

At presynaptic active zones (AZs), conserved scaffold protein architectures control synaptic vesicle (SV) release by defining the nanoscale distribution and density of voltage-gated Ca2+ channels (VGCCs). While AZs can potentiate SV release in the mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79847645598ba22cc261d90d97030338
https://repository.publisso.de/resource/frl:6440400