Characterization of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells

Autor: Caroline Frørup, Rebekka Gerwig, Cecilie Amalie Søndergaard Svane, Joana Mendes Lopes de Melo, Kristine Henriksen, Tina Fløyel, Flemming Pociot, Simranjeet Kaur, Joachim Størling

Publikováno v: Frontiers in Endocrinology, Vol 14 (2023)

ObjectiveEndoC-βH5 is a newly established human beta-cell model which may be superior to previous model systems. Exposure of beta cells to pro-inflammatory cytokines is widely used when studying immune-mediated beta-cell failure in type 1 diabetes.

Externí odkaz: https://doaj.org/article/f0dc1735d24643a2b3236ded1b388067

Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic β Cells

Autor: Simranjeet Kaur, Caroline Frørup, Aashiq H. Mirza, Tina Fløyel, Reza Yarani, Maikel L. Colli, Jesper Johannesen, Joachim Størling, Decio L. Eizirik, Flemming Pociot

Publikováno v: Non-Coding RNA, Vol 8, Iss 5, p 69 (2022)

Circular RNAs (circRNAs) have recently been implicated in impaired β-cell function in diabetes. Using microarray-based profiling of circRNAs in human EndoC-βH1 cells treated with pro-inflammatory cytokines, this study aimed to investigate the expre

Externí odkaz: https://doaj.org/article/a7ca1cd14fd24615ba17c8805c27ead5

β Cell and Autophagy:What Do We Know?

Autor: Hamid-Reza Mohammadi-Motlagh, Mona Sadeghalvad, Niloofar Yavari, Rosita Primavera, Setareh Soltani, Shashank Chetty, Abantika Ganguly, Shobha Regmi, Tina Fløyel, Simranjeet Kaur, Aashiq H. Mirza, Avnesh S. Thakor, Flemming Pociot, Reza Yarani

Publikováno v: Mohammadi-Motlagh, H R, Sadeghalvad, M, Yavari, N, Primavera, R, Soltani, S, Chetty, S, Ganguly, A, Regmi, S, Fløyel, T, Kaur, S, Mirza, A H, Thakor, A S, Pociot, F & Yarani, R 2023, ' β Cell and Autophagy : What Do We Know? ', Biomolecules, vol. 13, no. 4, 649 . https://doi.org/10.3390/biom13040649

Pancreatic β cells are central to glycemic regulation through insulin production. Studies show autophagy as an essential process in β cell function and fate. Autophagy is a catabolic cellular process that regulates cell homeostasis by recycling sur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06697f6bff8dd54feb09a56cc0b704b7
https://curis.ku.dk/ws/files/346594976/biomolecules_13_00649.pdf

SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients

Autor: Kira Meyerovich, Caroline Frørup, Simranjeet Kaur, Alessandra K Cardozo, Lotte B. Nielsen, Joachim Størling, Michala Prause, Henrik B. Mortensen, Flemming Pociot, Tina Fløyel

Publikováno v: Diabetes
Diabetes (New York, N.Y.), 70 (2

The single nucleotide polymorphism rs7804356 located in the Src kinase-associated phosphoprotein 2 (SKAP2) gene is associated with type 1 diabetes (T1D), suggesting SKAP2 as a causal candidate gene. The objective of the study was to investigate if SK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd6df5a8ff92b2bedf342d204cf3a140
https://doi.org/10.2337/db20-0092

SKAP2, a candidate gene for type 1 diabetes, regulates β-cell apoptosis and glycaemic control in newly diagnosed patients

Autor: Joachim Størling, Alessandra K. Cardozo, Flemming Pociot, Lotte B. Nielsen, Henrik B. Mortensen, Caroline Frørup, Simranjeet Kaur, Michala C. Prause, Kira Meyerovich, Tina Fløyel, Ada Admin

The single nucleotide polymorphism rs7804356 located in the Src kinase-associated phosphoprotein 2 (SKAP2) gene is associated with type 1 diabetes (T1D) suggesting SKAP2 as a causal candidate gene. The objective of the study was to investigate if SKA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::606059188a87cc65a4b2e50d7dcbdd5d
https://doi.org/10.2337/figshare.13217447.v1