Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Tina E Kjeldsen"'
Autor:
Dianna Hussmann, Anna Starnawska, Louise Kristensen, Iben Daugaard, Astrid Thomsen, Tina E. Kjeldsen, Christine Søholm Hansen, Jonas Bybjerg-Grauholm, Karina Dalsgaard Johansen, Maja Ludvigsen, Thomas Kristensen, Thomas Stauffer Larsen, Michael Boe Møller, Charlotte Guldborg Nyvold, Lise Lotte Hansen, Tomasz K. Wojdacz
Publikováno v:
Haematologica, Vol 107, Iss 4 (2021)
Currently, no molecular biomarker indices are used in standard care to make treatment decisions at diagnosis of chronic lymphocytic leukemia (CLL). We used Infinium MethylationEPIC array data from diagnostic blood samples of 114 CLL patients and deve
Externí odkaz:
https://doaj.org/article/c610eee3b3c743b6b035337410c7a22b
Autor:
Dianna Hussmann, Anna Starnawska, Louise Kristensen, Iben Daugaard, Oriane Cédile, Vivi Quoc Nguyen, Tina E. Kjeldsen, Christine Søholm Hansen, Jonas Bybjerg-Grauholm, Thomas Kristensen, Thomas Stauffer Larsen, Michael Boe Møller, Charlotte Guldborg Nyvold, Lise Lotte Hansen, Tomasz K. Wojdacz
Publikováno v:
Hussmann, D, Starnawska, A, Kristensen, L, Daugaard, I, Cédile, O, Nguyen, V Q, Kjeldsen, T E, Hansen, C S, Bybjerg-Grauholm, J, Kristensen, T, Larsen, T S, Møller, M B, Nyvold, C G, Hansen, L L & Wojdacz, T K 2022, ' Methylation microarray-based detection of clinical copy-number aberrations in CLL benchmarked to standard FISH analysis ', Genomics, vol. 114, no. 6, 110510 . https://doi.org/10.1016/j.ygeno.2022.110510
Copy-number aberrations (CNAs) are assessed using FISH analysis in diagnostics of chronic lymphocytic leukemia (CLL), but CNAs can also be extrapolated from Illumina BeadChips developed for genome-wide methylation microarray screening. Increasing num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9cd3264a2ed77dcbd52875375de962d
https://pubmed.ncbi.nlm.nih.gov/36272495
https://pubmed.ncbi.nlm.nih.gov/36272495
Autor:
Tina E Kjeldsen, Astrid Thomsen, Christine Søholm Hansen, Dianna Hussmann, Lise Lotte Hansen, Karina Dalsgaard Johansen, Thomas Kielsgaard Kristensen, Jonas Bybjerg-Grauholm, Louise Kristensen, Iben Daugaard, Thomas Stauffer Larsen, Tomasz K. Wojdacz, Anna Starnawska, Maja Ludvigsen, Michael Boe Møller, Charlotte Guldborg Nyvold
Publikováno v:
Hussmann, D, Starnawska, A, Kristensen, L, Daugaard, I, Thomsen, A, Kjeldsen, T, Hansen, C S, Bybjerg-Grauholm, J, Dalsgaard Johansen, K, Ludvigsen, M, Kristensen, T, Larsen, T S, Møller, M B, Nyvold, C G, Hansen, L L & Wojdacz, T K 2022, ' IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load ', Haematologica, vol. 107, no. 4, pp. 877-886 . https://doi.org/10.3324/haematol.2021.278477
Hussmann, D, Starnawska, A, Kristensen, L, Daugaard, I, Thomsen, A, Kjeldsen, T E, Hansen, C S, Bybjerg-Grauholm, J, Johansen, K D, Ludvigsen, M, Kristensen, T, Larsen, T S, Møller, M B, Nyvold, C G, Hansen, L L & Wojdacz, T K 2022, ' IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load ', Haematologica, vol. 107, no. 4, pp. 877-886 . https://doi.org/10.3324/haematol.2021.278477
Hussmann, D, Starnawska, A, Kristensen, L, Daugaard, I, Thomsen, A, Kjeldsen, T E, Hansen, C S, Bybjerg-Grauholm, J, Johansen, K D, Ludvigsen, M, Kristensen, T, Larsen, T S, Møller, M B, Nyvold, C G, Hansen, L L & Wojdacz, T K 2022, ' IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load ', Haematologica, vol. 107, no. 4, pp. 877-886 . https://doi.org/10.3324/haematol.2021.278477
Currently, no molecular biomarker indices are used in standard care to make treatment decisions at diagnosis of chronic lymphocytic leukemia (CLL). We used Infinium MethylationEPIC array data from diagnostic blood samples of 114 CLL patients and deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8015b7eb2deef9a766702d6fe297e3
https://pure.au.dk/portal/da/publications/ighvassociated-methylation-signatures-more-accurately-predict-clinical-outcomes-of-chronic-lymphocytic-leukemia-patients-than-ighv-mutation-load(fb8eb304-9b04-4160-b930-6f27f47e59cc).html
https://pure.au.dk/portal/da/publications/ighvassociated-methylation-signatures-more-accurately-predict-clinical-outcomes-of-chronic-lymphocytic-leukemia-patients-than-ighv-mutation-load(fb8eb304-9b04-4160-b930-6f27f47e59cc).html
Autor:
Dianna Hussmann, Lise Lotte Hansen, Iben Daugaard, Thomas Kielsgaard Kristensen, Tomasz K. Wojdacz, Thomas Stauffer Larsen, Tina E Kjeldsen, Louise Kristensen, Charlotte Guldborg Nyvold, Michael Boe Møller
Publikováno v:
Daugaard, I, Hussmann, D, Kristensen, L, Kristensen, T, Kjeldsen, T E, Nyvold, C G, Larsen, T S, Møller, M B, Hansen, L L & Wojdacz, T K 2018, ' Chronic lymphocytic leukemia patients with heterogeneously or fully methylated LPL promotor display longer time to treatment ', Epigenomics, vol. 10, no. 9, pp. 1155-1166 . https://doi.org/10.2217/epi-2018-0020
AIM: We investigated whether DNA methylation regulates expression of LPL and PI3K complex genes in chronic lymphocytic leukemia (CLL) and evaluated the prognostic significance of LPL promoter methylation in CLL patients. Patients & methods: Methylati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d834e2fe3428b7edb4b6c2f81b4d4e0
https://portal.findresearcher.sdu.dk/da/publications/a0202552-605e-4b74-bcac-3d9eeb4f3d83
https://portal.findresearcher.sdu.dk/da/publications/a0202552-605e-4b74-bcac-3d9eeb4f3d83
Publikováno v:
Daugaard, I L, Kjeldsen, T E, Hager, H, Hansen, L L & Wojdacz, T K 2015, ' The influence of DNA degradation in formalin-fixed, paraffin-embedded (FFPE) tissue on locus-specific methylation assessment by MS-HRM ', Experimental and Molecular Pathology, vol. 99, no. 3, pp. 632–640 . https://doi.org/10.1016/j.yexmp.2015.11.007
Readily accessible Formalin-Fixed Paraffin Embedded (FFPE) tissues are a highly valuable source of genetic material for molecular analyses in both research and in vitro diagnostics but frequently genetic material in those samples is highly degraded.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595dc92eafa3c5dd01a68dfba6202298
https://doi.org/10.1016/j.yexmp.2015.11.007
https://doi.org/10.1016/j.yexmp.2015.11.007
The association between miR-34 dysregulation and distant metastases formation in lung adenocarcinoma
Publikováno v:
Daugaard, I, Knudsen, A, Kjeldsen, T E, Hager, H & Hansen, L L 2017, ' The association between miR-34 dysregulation and distant metastases formation in lung adenocarcinoma ', Experimental and Molecular Pathology, vol. 102, no. 3, pp. 484-491 . https://doi.org/10.1016/j.yexmp.2017.05.012
Lung cancer has the highest mortality rate amongst human cancers and the majority of deaths can be attributed to metastatic spread. The miR-34 family includes three tumor suppressive miRs: miR-34a, miR-34b and miR-34c. miR-34 downregulation is a freq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7832d28b4399cbea89b2c0852a959a
https://pubmed.ncbi.nlm.nih.gov/28512015
https://pubmed.ncbi.nlm.nih.gov/28512015
Autor:
Tina E Kjeldsen, Jørgen Kjems, Morten T. Venø, Yan Yan, Iben Daugaard, Philippe Lamy, Lise Lotte Hansen, Henrik Hager
Publikováno v:
Oncotarget
Daugaard, I, Venø, M T, Yan, Y, Kjeldsen, T E, Lamy, P, Hager, H, Kjems, J & Hansen, L L 2017, ' Small RNA sequencing reveals metastasis-related microRNAs in lung adenocarcinoma ', OncoTarget, vol. 8, no. 16, pp. 27047-27061 . https://doi.org/10.18632/oncotarget.15968
Daugaard, I, Venø, M T, Yan, Y, Kjeldsen, T E, Lamy, P, Hager, H, Kjems, J & Hansen, L L 2017, ' Small RNA sequencing reveals metastasis-related microRNAs in lung adenocarcinoma ', OncoTarget, vol. 8, no. 16, pp. 27047-27061 . https://doi.org/10.18632/oncotarget.15968
// Iben Daugaard 1, 2 , Morten T. Veno 2 , Yan Yan 2 , Tina E. Kjeldsen 1 , Philippe Lamy 4 , Henrik Hager 3, 5 , Jorgen Kjems 2 , Lise Lotte Hansen 1 1 Department of Biomedicine, Aarhus University, DK-8000 Aarhus C, Denmark 2 Department of Molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918d1bd2206ceb6ade5607401916b720
https://pubmed.ncbi.nlm.nih.gov/28460486
https://pubmed.ncbi.nlm.nih.gov/28460486
Autor:
Diana Dominguez, Tomasz K. Wojdacz, Iben Daugaard, Tina E Kjeldsen, Henrik Hager, Lasse Sommer Kristensen, Lise Lotte Hansen
Publikováno v:
Scientific Reports
Daugaard, I, Dominguez, D, Kjeldsen, T E, Kristensen, L S, Hager, H, Wojdacz, T K & Hansen, L L 2016, ' Identification and validation of candidate epigenetic biomarkers in lung adenocarcinoma ', Scientific Reports, vol. 6, 35807 . https://doi.org/10.1038/srep35807
Daugaard, I, Dominguez, D, Kjeldsen, T E, Kristensen, L S, Hager, H, Wojdacz, T K & Hansen, L L 2016, ' Identification and validation of candidate epigenetic biomarkers in lung adenocarcinoma ', Scientific Reports, vol. 6, 35807 . https://doi.org/10.1038/srep35807
Lung cancer is the number one cause of cancer-related deaths worldwide. DNA methylation is an epigenetic mechanism that regulates gene expression, and disease-specific methylation changes can be targeted as biomarkers. We have compared the genome-wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::811c86a2ac28c65038ca03570dda334e
https://pubmed.ncbi.nlm.nih.gov/27782156
https://pubmed.ncbi.nlm.nih.gov/27782156
Autor:
Michael Boe Møller, Tomasz K. Wojdacz, Lise Lotte Hansen, Thomasz Kristensen, Henrik Hager, Louise Kristensen, Tina E Kjeldsen, Iben Daugaard
Publikováno v:
Cancer Research. 77:4359-4359
There is no doubt that testing for disease specific methylation changes can guide disease risk assessment, facilitate detection of the disease, support prognostication and personalization of treatment as well as guide post treatment patient care (1).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06c1e883b262bde6cee99d78db87f06d
https://doi.org/10.1158/1538-7445.am2017-4359
https://doi.org/10.1158/1538-7445.am2017-4359
Autor:
Helene Myrtue Nielsen, Kirsten Grønbæk, Marianne Bach Treppendahl, Tina E Kjeldsen, Elisabeth Ralfkiaer, Fazila Asmar, Mia Seremet Girkov, Lasse Sommer Kristensen, Lise Lotte Hansen
Publikováno v:
Scientific Reports
Kristensen, L S, Treppendahl, M B, Asmar, F, Girkov, M S, Nielsen, H M, Kjeldsen, T E, Ralfkiaer, E, Hansen, L L & Grønbæk, K 2013, ' Investigation of MGMT and DAPK1 methylation patterns in diffuse large B-cell lymphoma using allelic MSP-pyrosequencing ', Scientific Reports, vol. 3, pp. 2789 . https://doi.org/10.1038/srep02789
Kristensen, L S, Treppendahl, M B, Asmar, F, Girkov, M S, Nielsen, H M, Kjeldsen, T E, Ralfkiaer, E, Hansen, L L & Grønbæk, K 2013, ' Investigation of MGMT and DAPK1 methylation patterns in diffuse large B-cell lymphoma using allelic MSP-pyrosequencing ', Scientific Reports, vol. 3, pp. 2789 . https://doi.org/10.1038/srep02789
The tumor suppressor genes MGMT and DAPK1 become methylated in several cancers including diffuse large B-cell lymphoma (DLBCL). However, allelic methylation patterns have not been investigated in DLBCL. We developed a fast and cost-efficient method f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ab3e5635f24daab29283c8209f6387
https://doi.org/10.1038/srep02789
https://doi.org/10.1038/srep02789