IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load

Autor: Dianna Hussmann, Anna Starnawska, Louise Kristensen, Iben Daugaard, Astrid Thomsen, Tina E. Kjeldsen, Christine Søholm Hansen, Jonas Bybjerg-Grauholm, Karina Dalsgaard Johansen, Maja Ludvigsen, Thomas Kristensen, Thomas Stauffer Larsen, Michael Boe Møller, Charlotte Guldborg Nyvold, Lise Lotte Hansen, Tomasz K. Wojdacz

Publikováno v: Haematologica, Vol 107, Iss 4 (2021)

Currently, no molecular biomarker indices are used in standard care to make treatment decisions at diagnosis of chronic lymphocytic leukemia (CLL). We used Infinium MethylationEPIC array data from diagnostic blood samples of 114 CLL patients and deve

Externí odkaz: https://doaj.org/article/c610eee3b3c743b6b035337410c7a22b

IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load

Autor: Tina E Kjeldsen, Astrid Thomsen, Christine Søholm Hansen, Dianna Hussmann, Lise Lotte Hansen, Karina Dalsgaard Johansen, Thomas Kielsgaard Kristensen, Jonas Bybjerg-Grauholm, Louise Kristensen, Iben Daugaard, Thomas Stauffer Larsen, Tomasz K. Wojdacz, Anna Starnawska, Maja Ludvigsen, Michael Boe Møller, Charlotte Guldborg Nyvold

Publikováno v: Hussmann, D, Starnawska, A, Kristensen, L, Daugaard, I, Thomsen, A, Kjeldsen, T, Hansen, C S, Bybjerg-Grauholm, J, Dalsgaard Johansen, K, Ludvigsen, M, Kristensen, T, Larsen, T S, Møller, M B, Nyvold, C G, Hansen, L L & Wojdacz, T K 2022, ' IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load ', Haematologica, vol. 107, no. 4, pp. 877-886 . https://doi.org/10.3324/haematol.2021.278477
Hussmann, D, Starnawska, A, Kristensen, L, Daugaard, I, Thomsen, A, Kjeldsen, T E, Hansen, C S, Bybjerg-Grauholm, J, Johansen, K D, Ludvigsen, M, Kristensen, T, Larsen, T S, Møller, M B, Nyvold, C G, Hansen, L L & Wojdacz, T K 2022, ' IGHV-associated methylation signatures more accurately predict clinical outcomes of chronic lymphocytic leukemia patients than IGHV mutation load ', Haematologica, vol. 107, no. 4, pp. 877-886 . https://doi.org/10.3324/haematol.2021.278477

Currently, no molecular biomarker indices are used in standard care to make treatment decisions at diagnosis of chronic lymphocytic leukemia (CLL). We used Infinium MethylationEPIC array data from diagnostic blood samples of 114 CLL patients and deve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf8015b7eb2deef9a766702d6fe297e3
https://pure.au.dk/portal/da/publications/ighvassociated-methylation-signatures-more-accurately-predict-clinical-outcomes-of-chronic-lymphocytic-leukemia-patients-than-ighv-mutation-load(fb8eb304-9b04-4160-b930-6f27f47e59cc).html

The influence of DNA degradation in formalin-fixed, paraffin-embedded (FFPE) tissue on locus-specific methylation assessment by MS-HRM

Autor: Iben Daugaard, Tomasz K. Wojdacz, Lise Lotte Hansen, Henrik Hager, Tina E Kjeldsen

Publikováno v: Daugaard, I L, Kjeldsen, T E, Hager, H, Hansen, L L & Wojdacz, T K 2015, ' The influence of DNA degradation in formalin-fixed, paraffin-embedded (FFPE) tissue on locus-specific methylation assessment by MS-HRM ', Experimental and Molecular Pathology, vol. 99, no. 3, pp. 632–640 . https://doi.org/10.1016/j.yexmp.2015.11.007

Readily accessible Formalin-Fixed Paraffin Embedded (FFPE) tissues are a highly valuable source of genetic material for molecular analyses in both research and in vitro diagnostics but frequently genetic material in those samples is highly degraded.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::595dc92eafa3c5dd01a68dfba6202298
https://doi.org/10.1016/j.yexmp.2015.11.007

The association between miR-34 dysregulation and distant metastases formation in lung adenocarcinoma

Autor: Alice Knudsen, Henrik Hager, Lise Lotte Hansen, Iben Daugaard, Tina E Kjeldsen

Publikováno v: Daugaard, I, Knudsen, A, Kjeldsen, T E, Hager, H & Hansen, L L 2017, ' The association between miR-34 dysregulation and distant metastases formation in lung adenocarcinoma ', Experimental and Molecular Pathology, vol. 102, no. 3, pp. 484-491 . https://doi.org/10.1016/j.yexmp.2017.05.012

Lung cancer has the highest mortality rate amongst human cancers and the majority of deaths can be attributed to metastatic spread. The miR-34 family includes three tumor suppressive miRs: miR-34a, miR-34b and miR-34c. miR-34 downregulation is a freq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc7832d28b4399cbea89b2c0852a959a
https://pubmed.ncbi.nlm.nih.gov/28512015

Abstract 4359: Systematic approach to methylation biomarker development in chronic lymphocytic leukemia, breast and lung cancers

Autor: Michael Boe Møller, Tomasz K. Wojdacz, Lise Lotte Hansen, Thomasz Kristensen, Henrik Hager, Louise Kristensen, Tina E Kjeldsen, Iben Daugaard

Publikováno v: Cancer Research. 77:4359-4359

There is no doubt that testing for disease specific methylation changes can guide disease risk assessment, facilitate detection of the disease, support prognostication and personalization of treatment as well as guide post treatment patient care (1).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06c1e883b262bde6cee99d78db87f06d
https://doi.org/10.1158/1538-7445.am2017-4359