Protein phosphatase 2A holoenzymes regulate leucine-rich repeat kinase 2 phosphorylation and accumulation

Autor: Katia Cailliau, Réginald Lefebvre, Alain Martoriati, R. Jeremy Nichols, Glenda M. Halliday, Tina De Wit, Chris Van den Haute, Marco Emanuele, William Sibran, Coline Leghay, Matthieu Drouyer, Shigeo Murayama, Marc Bolliger, Jean-François Bodart, Jean-Marc Taymans, Veerle Baekelandt, Evy Lobbestael, Nicolas Dzamko, Marie-Christine Chartier-Harlin, Eugénie Mutez

Publikováno v: Neurobiology of Disease
Neurobiology of Disease, Elsevier, 2021, 157, pp.105426. ⟨10.1016/j.nbd.2021.105426⟩
Neurobiology of Disease, Vol 157, Iss, Pp 105426-(2021)
Neurobiology of Disease, 2021, 157, pp.105426. ⟨10.1016/j.nbd.2021.105426⟩

LRRK2 is a highly phosphorylated multidomain protein and mutations in the gene encoding LRRK2 are a major genetic determinant of Parkinson's disease (PD). Dephosphorylation at LRRK2's S910/S935/S955/S973 phosphosite cluster is observed in several con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a8ddafe9dc8af16d33dd86a9887abcb
https://lirias.kuleuven.be/handle/123456789/679568

LRRK2 kinase inhibition, a potential Parkinson’s disease therapy, induces LRRK2 protein destabilization and proteasomal degradation

Autor: Jean-Marc Taymans, Veerle Baekelandt, Evy Lobbestael, Laura Civiero, Tina De Wit, Elisa Greggio

Publikováno v: Frontiers in Neuroscience. 11

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a7dd108302170b074771c105bfaeb1