Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Tina Catalano"'
Autor:
Owen A. O'Connor, Yaping Shou, Kathleen Roberge, Anca Milea, Eric L. Sievers, Robert A. Uger, Penka S. Petrova, Tina Catalano, Lisa D.S. Johnson, Oleg E. Akilov, Christiane Querfeld, Kerry J. Savage, Jasmine Zain, Matthew G. Mei, Steven M. Horwitz, James M. Foran, Anjali S. Advani, Mary-Elizabeth M. Percival, Diego Villa, Mark D. Minden, Ahmed Sawas, Ian W. Flinn, Robert W. Chen, Alexander M. Lesokhin, Michael B. Maris, Stephen M. Ansell
Study Schema
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::281c50bb0e69ede50363e21f4afa6737
https://doi.org/10.1158/1078-0432.22482851.v1
https://doi.org/10.1158/1078-0432.22482851.v1
Autor:
Owen A. O'Connor, Yaping Shou, Kathleen Roberge, Anca Milea, Eric L. Sievers, Robert A. Uger, Penka S. Petrova, Tina Catalano, Lisa D.S. Johnson, Oleg E. Akilov, Christiane Querfeld, Kerry J. Savage, Jasmine Zain, Matthew G. Mei, Steven M. Horwitz, James M. Foran, Anjali S. Advani, Mary-Elizabeth M. Percival, Diego Villa, Mark D. Minden, Ahmed Sawas, Ian W. Flinn, Robert W. Chen, Alexander M. Lesokhin, Michael B. Maris, Stephen M. Ansell
Purpose:TTI-621 (SIRPα-IgG1 Fc) is a novel checkpoint inhibitor that activates antitumor activity by blocking the CD47 “don't eat me” signal. This first-in-human phase I study (NCT02663518) evaluated the safety and activity of TTI-621 in relapse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6229d70998f979096284ba3849db926
https://doi.org/10.1158/1078-0432.c.6531017
https://doi.org/10.1158/1078-0432.c.6531017
Autor:
Ian W. Flinn, Yaping Shou, Bob Uger, James M. Foran, Mary-Elizabeth M. Percival, Diego Villa, Kathleen Large, Catherine Diefenbach, Stephen M. Ansell, Youn H. Kim, Ahmed Sawas, Craig Okada, Kerry J. Savage, Gloria H. Y. Lin, Tatyana Feldman, Oleg E. Akilov, Steven M. Horwitz, Michael B. Maris, Lubomir Sokol, Mark D. Minden, Deepa Jagadeesh, Penka S. Petrova, Tina Catalano, Matthew Mei, Naomi Molloy
Publikováno v:
Blood. 136:41-43
Background CD47 is an innate immune checkpoint that binds signal regulatory protein alpha (SIRPα) and delivers a "do not eat" signal to suppress macrophage phagocytosis. Overexpression of CD47 can allow tumor cells to escape immune surveillance. TTI
Autor:
Ahmed Sawas, Tina Catalano, Ian W. Flinn, Kathleen Roberge, Oleg E. Akilov, Mary Elizabeth Percival, Yaping Shou, Steven M. Horwitz, Mark D. Minden, Owen A. O'Connor, Anjali S. Advani, Penka S. Petrova, Stephen M. Ansell, Christiane Querfeld, Robert W. Chen, Anca Milea, James M. Foran, Eric L. Sievers, Robert A. Uger, Alexander M. Lesokhin, Lisa Johnson, Matthew Mei, Kerry J. Savage, Jasmine Zain, Diego Villa, Michael B. Maris
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 27(8)
Purpose: TTI-621 (SIRPα-IgG1 Fc) is a novel checkpoint inhibitor that activates antitumor activity by blocking the CD47 “don't eat me” signal. This first-in-human phase I study (NCT02663518) evaluated the safety and activity of TTI-621 in relaps
Autor:
Krish Patel, Jeffrey A. Zonder, Dahlia Sano, Michael Maris, Alexander Lesokhin, Gottfried von Keudell, Catherine Lai, Rod Ramchandren, Tina Catalano, Gloria H. Y. Lin, Bob Uger, Penka S. Petrova, Naomi Molloy, Ingmar Bruns, Swaminathan P Iyer
Publikováno v:
Blood. 138:3560-3560
Background CD47 is an innate immune checkpoint that binds signal regulatory protein alpha (SIRPα) and delivers a "don't eat me" signal to suppress macrophage phagocytosis. Overexpression of CD47 serves as a mechanism of immune surveillance evasion,
Autor:
Steven M. Horwitz, James M. Foran, Michael Maris, Jennifer Kimberly Lue, Ahmed Sawas, Craig Okada, Tatyana A. Feldman, Lubomir Sokol, Matthew Mei, Ian W. Flinn, Diego Villa, Mary-Elizabeth M. Percival, Deepa Jagadeesh, Kerry J. Savage, Oleg Akilov, Catherine S. Diefenbach, Youn H. Kim, Gloria H. Y. Lin, Tina Catalano, Penka S. Petrova, Bob Uger, Naomi Molloy, Kathleen Large, Ingmar Bruns, Stephen M. Ansell
Publikováno v:
Blood. 138:2448-2448
Background CD47 is an innate immune checkpoint that binds signal regulatory protein alpha (SIRPα) and delivers a "don't eat me" signal to suppress macrophage phagocytosis. Overexpression of CD47 can allow tumor cells to escape immune surveillance. T
Autor:
Michael B. Maris, Bruce D. Cheson, Erlene K. Seymour, Kathleen Roberge, Swami P. Iyer, Krish Patel, Yaping Shou, Tina Catalano, Alexander M. Lesokhin, Bob Uger, Gottfried von Keudell, Gloria H. Y. Lin, Penka S. Petrova, Jeff Zonder, Radhakrishnan Ramchandren
Publikováno v:
Blood. 136:46-47
Background CD47 is an innate immune checkpoint that binds signal regulatory protein alpha (SIRPα) and delivers a "do not eat" signal to suppress macrophage phagocytosis. Overexpression of CD47 serves as a mechanism of immune surveillance evasion, an
Autor:
Erlene K. Seymour, Radhakrishnan Ramchandren, Gottfried von Keudell, Gloria H. Y. Lin, Swaminathan Padmanabhan Iyer, Yaping Shou, Bruce D. Cheson, Michael B. Maris, Jeffrey A. Zonder, Tina Catalano, Alexander M. Lesokhin, Krish Patel
Publikováno v:
Journal of Clinical Oncology. 38:3030-3030
3030 Background: CD47 is an immune checkpoint that binds signal regulatory protein alpha (SIRPα) and delivers a "do not eat" signal to suppress macrophage phagocytosis. Cancer cells frequently overexpress CD47 to escape immune surveillance. TTI-622
Autor:
Chunlei Wang, Jaehyun Choi, Bolette Bossen, Andrew Marshall, David Rosa, Robert A. Uger, Tina Catalano, Peter Dove, Jeff Winston, Zezhou Wang, Malik Slassi, Mark Wong, Penka S. Petrova
Aberrant EGFR activity is implicated in certain central nervous system (CNS) tumors, including GBM and brain metastases of NSCLC, which occur in almost half of NSCLC patients. Current approved EGFR inhibitors, however, have very limited efficacy agai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f1186f6d276f986e0450d67459dd7e
https://europepmc.org/articles/PMC5692393/
https://europepmc.org/articles/PMC5692393/
Autor:
Natasja Nielsen Viller, Laura Brinen, Zezhou Wang, Tina Catalano, Carole Galligan, Karen Dodge, Simone Helke, Robert A. Uger, Vivian S. Lee, Bolette Bossen, Peter Dove, Jeff Winston, Mark Wong, Gloria H. Y. Lin, Malik Slassi, David A. Rosa, Marilyse Charbonneau
Publikováno v:
Cancer Research. 79:3854-3854
The cGAS-STING pathway plays a pivotal role in sensing aberrant cytoplasmic DNA fragments derived from pathogens or host tumor cells and initiating an innate immune response. STING activation induces type I IFNs and a cascade of other pro-inflammator