Výsledky vyhledávání - "Tina Baessler"

Data from Glucocorticoid-Induced Tumor Necrosis Factor Receptor–Related Protein Ligand Subverts Immunosurveillance of Acute Myeloid Leukemia in Humans

Autor: Helmut Rainer Salih, Helga Maria Schmetzer, Alexander Wacker, Katrin Miriam Baltz, Mercedes Kloss, Benjamin Joachim Schmiedel, Matthias Krusch, Tina Baessler

The reciprocal interaction of tumor cells with the immune system is influenced by various members of the tumor necrosis factor (TNF)/TNF receptor (TNFR) family, and recently, glucocorticoid-induced TNFR-related protein (GITR) was shown to stimulate a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::72191a9f473a95ea6582e32b1a2124b9
https://doi.org/10.1158/0008-5472.c.6499916.v1

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Osteoprotegerin Positively Regulates Hematopoietic Progenitor Cells

Autor: Katja Weisel, Sedat Yildirim, Robert Möhle, Lothar Kanz, Eric Schweikle, Tina Baessler

Publikováno v: Current Stem Cell Research & Therapy. 7:72-77

Osteoprotegerin (OPG), the soluble decoy receptor of RANKL is released by bone marrow osteoblasts and plays an important role in physiological osteoblastogenesis and pathological bone disease. In earlier studies, we have shown that generated stromal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c6f6bd5439bfb14df065893e98182e
https://doi.org/10.2174/157488812798483458

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4-1BB ligand modulates direct and Rituximab-induced NK-cell reactivity in chronic lymphocytic leukemia

Autor: Ludger Grosse-Hovest, Kilian Rittig, Benjamin J Schmiedel, Tina Baessler, Helmut R. Salih, Carla E. Schumacher, Corina Buechele

Publikováno v: European Journal of Immunology. 42:737-748

NK cells play an important role in tumor immunosurveillance and largely contribute to the therapeutic success of anti-tumor antibodies like Rituximab. Here, we studied the role of the TNF family member 4-1BB ligand (4-1BBL) during the interaction of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cee7e9b5e6e51514cd6f29850eda096e
https://doi.org/10.1002/eji.201141920

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Glucocorticoid-induced TNFR-related protein (GITR) ligand modulates cytokine release and NK cell reactivity in chronic lymphocytic leukemia (CLL)

Autor: Helmut R. Salih, Corina Buechele, Stefan Wirths, Tina Baessler, Benjamin J Schmiedel, J U Schmohl

Publikováno v: Leukemia. 26:991-1000

Natural killer (NK) cells play an important role in the immunosurveillance of hematopoietic malignancies. Their reactivity is influenced by activating and inhibitory signals mediated by tumor-expressed ligands for NK receptors. Many members of the tu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec1e1283c8dddebb282122af4069a205
https://doi.org/10.1038/leu.2011.313

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CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK-cell reactivity against human acute myeloid leukemia cells

Autor: Alexander Wacker, Hans-Georg Rammensee, Benjamin J Schmiedel, Frank Grünebach, Helmut R. Salih, Jean Enno Charton, Tina Baessler, Matthias Krusch

Publikováno v: Blood. 115:3058-3069

Natural killer (NK) cells play an important role in the immunosurveillance of leukemia. Their reactivity is governed by a balance of activating and inhibitory receptors including various members of the tumor necrosis factor receptor (TNFR) family. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f659f48cead08c517b0a81379aa8ce
https://doi.org/10.1182/blood-2009-06-227934

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The Kinase Inhibitors Sunitinib and Sorafenib Differentially Affect NK Cell Antitumor Reactivity In Vitro

Autor: Julia Salih, Matthias Krusch, Tina Baessler, Kerstin Maria Kampa, Frank Mayer, Manuela Schlicke, Helmut R. Salih

Publikováno v: The Journal of Immunology. 183:8286-8294

Sunitinib and Sorafenib are protein kinase inhibitors (PKI) approved for treatment of patients with advanced renal cell cancer (RCC). However, long-term remissions of advanced RCC have only been observed after IL-2 treatment, which underlines the imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b7218198f33c131f31be26859375f1
https://doi.org/10.4049/jimmunol.0902404

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Glucocorticoid-Induced Tumor Necrosis Factor Receptor–Related Protein Ligand Subverts Immunosurveillance of Acute Myeloid Leukemia in Humans

Autor: Mercedes Kloss, Helga Schmetzer, Matthias Krusch, Helmut R. Salih, Tina Baessler, Benjamin J Schmiedel, Katrin M. Baltz, Alexander Wacker

Publikováno v: Cancer Research. 69:1037-1045

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0454b0fae5d47b8bdd41bd3d0b907da6
https://doi.org/10.1158/0008-5472.can-08-2650

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Interaction of Monocytes with NK Cells upon Toll-Like Receptor-Induced Expression of the NKG2D Ligand MICA

Autor: Alexander Steinle, Patrice Decker, Gundram Jung, Matthias Krusch, Katrin M. Baltz, Mercedes Kloss, Hans-Georg Rammensee, Tina Baessler, Helmut R. Salih

Publikováno v: The Journal of Immunology. 181:6711-6719

Reciprocal interactions between NK cells and dendritic cells have been shown to influence activation of NK cells, maturation, or lysis of dendritic cells and subsequent adaptive immune responses. However, little is known about the crosstalk between m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4378dcb2b53f060cf8eb324dee51424a
https://doi.org/10.4049/jimmunol.181.10.6711

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Neutralization of tumor-derived soluble Glucocorticoid-Induced TNFR-Related Protein ligand increases NK cell anti-tumor reactivity

Autor: Peter Brossart, Anita Bringmann, Benjamin J Schmiedel, Katrin M. Baltz, Helmut R. Salih, Matthias Krusch, Tina Baessler

Publikováno v: Blood. 112:3735-3743

NK cell anti-tumor reactivity is governed by a balance of activating and inhibitory receptors including various TNF receptor (TNFR) family members. Here we report that human tumor cells release a soluble form of the TNF family member Glucocorticoid-I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fdefede6c28c3f2bd1767546ef2e82d
https://doi.org/10.1182/blood-2008-03-143016

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