Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Tina A Müller"'
Autor:
Alice R Walker, Pavel Silvestrov, Tina A Müller, Robert H Podolsky, Gregory Dyson, Robert P Hausinger, Gerardo Andrés Cisneros
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 2, p e1005345 (2017)
The search for prostate cancer biomarkers has received increased attention and several DNA repair related enzymes have been linked to this dysfunction. Here we report a targeted search for single nucleotide polymorphisms (SNPs) and functional impact
Externí odkaz:
https://doaj.org/article/d2c949b3530f40688630c45a904a8f10
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67403 (2013)
Potential roles of the abasic site lyase activity associated with AlkB homolog 1 (ALKBH1) were assessed by studies focusing on the two cellular processes that create abasic sites as intermediates: base excision repair and class switch recombination.
Externí odkaz:
https://doaj.org/article/b6f16e4de5f54e2ca7d750f7065bfd15
Autor:
Tina Orth-Müller
Publikováno v:
Medialatinitas ISBN: 9783700185932
Medialatinitas
Medialatinitas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8f5e8401e4e3f9847eb9a9571e62e2a
https://doi.org/10.1553/0x003c188es75
https://doi.org/10.1553/0x003c188es75
Publikováno v:
Biochemical and Biophysical Research Communications. 495:98-103
Alkbh1 is a mammalian homolog of the Escherichia coli DNA repair enzyme AlkB, an Fe(II) and 2-oxoglutarate dependent dioxygenase that removes alkyl lesions from DNA bases. The human homolog ALKBH1 has been associated with six different enzymatic acti
Publikováno v:
Biochemistry. 56:1899-1910
Alkbh1 is one of nine mammalian homologues of Escherichia coli AlkB, a 2-oxoglutarate-dependent dioxygenase that catalyzes direct DNA repair by removing alkyl lesions from DNA. Six distinct enzymatic activities have been reported for Alkbh1, includin
Publikováno v:
Inorganic Chemistry. 54:2278-2283
The thermodynamic properties of Fe2+ binding to the 2-His-1-carboxylate facial triad in α-ketoglutarate/taurine dioxygenase (TauD) were explored using isothermal titration calorimetry. Direct titrations of Fe2+ into TauD and chelation experiments in
Publikováno v:
Journal of Molecular Graphics and Modelling. 54:123-130
The ability to repair DNA is important for the conservation of genetic information of living organisms. Cells have a number of ways to restore a damaged DNA, such as direct DNA repair, base excision repair, and nucleotide excision repair. One of the
Publikováno v:
Biochemistry. 56(13)
Alkbh1 is one of nine mammalian homologues of Escherichia coli AlkB, a 2-oxoglutarate-dependent dioxygenase that catalyzes direct DNA repair by removing alkyl lesions from DNA. Six distinct enzymatic activities have been reported for Alkbh1, includin
Autor:
Robert H. Podolsky, Alice R. Walker, Robert P. Hausinger, Tina A. Müller, Pavel Silvestrov, Gerardo Andrés Cisneros, Gregory Dyson
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 2, p e1005345 (2017)
PLoS Computational Biology
PLoS Computational Biology
The search for prostate cancer biomarkers has received increased attention and several DNA repair related enzymes have been linked to this dysfunction. Here we report a targeted search for single nucleotide polymorphisms (SNPs) and functional impact
Publikováno v:
Biochemical Journal. 452:509-518
ALKBH1 (AlkB homologue 1) is a mammalian AlkB (2-oxoglutarate-dependent dioxygenase) homologue that possesses AP (abasic or apurinic/apyrimidinic) lyase activity. The AP lyase reaction is catalysed by imine formation with an active site lysine residu