Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Tina, Seitz"'
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189521 (2017)
Ranitidine (Zantac®) is a H2-receptor antagonist commonly used for the treatment of acid-related gastrointestinal diseases. Ranitidine was reported to be a substrate of the organic cation transporters OCT1 and OCT2. The hepatic transporter OCT1 is h
Externí odkaz:
https://doaj.org/article/c483c50f0fcd4e85b32d1b58bccc2850
Autor:
Tina Seitz, Barbara Zdrazil, Sarah Römer, Jürgen Brockmöller, Stefan Oswald, Christoph Wenzel, Jochen Gaedcke, Mladen V. Tzvetkov, Alzbeta Tuerkova, Marleen Julia Meyer
Publikováno v:
Drug Metabolism and Disposition. 48:1380-1392
The most commonly used oral antidiabetic drug, metformin, is a substrate of the hepatic uptake transporter OCT1 (gene name SLC22A1). However, OCT1 deficiency leads to more pronounced reductions of metformin concentrations in mouse than in human liver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2f849b1f125a11656d2269d6826b5f
https://doi.org/10.1124/dmd.120.000170
https://doi.org/10.1124/dmd.120.000170
Autor:
Marleen J. Meyer, Pascale C.F. Schreier, Mert Basaran, Stefaniia Vlasova, Tina Seitz, Jürgen Brockmöller, Barbara Zdrazil, Mladen V. Tzvetkov
Publikováno v:
The Journal of biological chemistry. 298(6)
Organic cation transporter 1 (OCT1) is a membrane transporter that affects hepatic uptake of cationic and weakly basic drugs. OCT1 transports structurally highly diverse substrates. The mechanisms conferring this polyspecificity are unknown. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01519a53471b23ba880be791e5c471c7
https://pubmed.ncbi.nlm.nih.gov/35469921
https://pubmed.ncbi.nlm.nih.gov/35469921
Autor:
Tina Seitz, Sherin Pojar, Jürgen Brockmöller, Mladen V. Tzvetkov, Frank Faltraco, Sabrina Vogler, Thomas Prukop, Johannes Matthaei
Publikováno v:
Clinical Pharmacology & Therapeutics. 103:868-878
Fenoterol is a widely used anti-asthmatic and tocolytic agent, but high plasma concentrations of fenoterol may lead to severe and even fatal adverse reactions. We studied whether heritable deficiency of the liver organic cation transporter 1 (OCT1),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a273d7daf476c3648510a1e297d1df4
https://doi.org/10.1002/cpt.812
https://doi.org/10.1002/cpt.812
Publikováno v:
Biological Chemistry. 398:237-249
Tropane alkaloids and their derivatives are anticholinergic drugs with narrow therapeutic range. Here we characterize the organic cation transporters from the SLC22 (OCT1, OCT2, and OCT3) and the SLC47 families (MATE1 and MATE2-K) as potential mediat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2994439357e81f43414ff6aa0ac29e
https://doi.org/10.1515/hsz-2016-0236
https://doi.org/10.1515/hsz-2016-0236
Autor:
Annabelle Tann, Tina Seitz, Mladen V. Tzvetkov, Jürgen Brockmöller, Thomas Prukop, Ole Jensen, Johannes Matthaei, Sina Tadjerpisheh
Publikováno v:
Clinical pharmacology and therapeutics. 105(1)
Cycloguanil, the active metabolite of proguanil, acts on malaria schizonts in erythrocytes and hepatocytes. We analyzed the impact of the organic cation transporter OCT1 on hepatocellular uptake and pharmacokinetics of proguanil and cycloguanil. OCT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2abe82a7196364fffa81a653ec3dcbe
https://pubmed.ncbi.nlm.nih.gov/29882324
https://pubmed.ncbi.nlm.nih.gov/29882324
Autor:
Mladen V, Tzvetkov, Johannes, Matthaei, Sherin, Pojar, Frank, Faltraco, Sabrina, Vogler, Thomas, Prukop, Tina, Seitz, Jürgen, Brockmöller
Publikováno v:
Clinical pharmacology and therapeutics. 103(5)
Fenoterol is a widely used anti-asthmatic and tocolytic agent, but high plasma concentrations of fenoterol may lead to severe and even fatal adverse reactions. We studied whether heritable deficiency of the liver organic cation transporter 1 (OCT1),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b10717f9f546e48fe42f0df09f3ec299
https://pubmed.ncbi.nlm.nih.gov/28791698
https://pubmed.ncbi.nlm.nih.gov/28791698
Autor:
Jiayin, Chen, Jürgen, Brockmöller, Tina, Seitz, Jörg, König, Mladen V, Tzvetkov, Xijing, Chen
Publikováno v:
Biological Chemistry. 398:813-813
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e90b32dbe1992ff10a6d2e9f24ba8ab3
https://doi.org/10.1515/hsz-2017-0129
https://doi.org/10.1515/hsz-2017-0129
Autor:
Hermann Koepsell, Thomas D. Mueller, Mladen V. Tzvetkov, Tina Seitz, Jürgen Brockmöller, Kristin Bokelmann
Publikováno v:
Blood. 123(9)
To the editor: Recently, the Met408-Del420 haplotype in the OCT1 gene (the combination of methionine at codon 408 and a deletion of another methionine at codon 420) was associated with lack of transport activity for imatinib and tetraethylammonium (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abce767d4dd6ed85b8a420ce3875f0ea
https://pubmed.ncbi.nlm.nih.gov/24578499
https://pubmed.ncbi.nlm.nih.gov/24578499
Publikováno v:
Breast cancer research and treatment. 137(1)
Heparins seem to improve survival in patients with advanced malignancies independently of their anticoagulatory function. As the treatment options in advanced and metastatic breast cancer are still very limited, heparins might be an interesting addit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96a8551456a78d25865334850758b7a
https://pubmed.ncbi.nlm.nih.gov/23160925
https://pubmed.ncbi.nlm.nih.gov/23160925