Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Tina, Izard"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Talin regulates crucial cellular functions, including cell adhesion and motility, and affects human diseases. Triggered by mechanical forces, talin plays crucial roles in facilitating the formation of focal adhesions and recruiting essential
Externí odkaz:
https://doaj.org/article/e7c7fda13d58434e93dff41c5b0c0699
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-10 (2023)
CryoEM structures capture the initial α-catenin interaction with F-actin before the sensing of force.
Externí odkaz:
https://doaj.org/article/e51f525253eb4d30b858d3c2ad3e10bb
Autor:
Lizhou Zhang, Cody B. Jackson, Huihui Mou, Amrita Ojha, Haiyong Peng, Brian D. Quinlan, Erumbi S. Rangarajan, Andi Pan, Abigail Vanderheiden, Mehul S. Suthar, Wenhui Li, Tina Izard, Christoph Rader, Michael Farzan, Hyeryun Choe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
SARS-CoV-2 variants with spike (S)-protein D614G mutations currently predominate globally. Here, Zhang et al. hypothesize that D614G variant may increase infectivity by increasing S protein abundance on the virion since pseudoviruses carrying S-G614
Externí odkaz:
https://doaj.org/article/5ab81391dfd1486295e3c90c83762edb
Publikováno v:
Matrix Biology Plus, Vol 12, Iss , Pp 100074- (2021)
The Neurofibromatosis type 2 gene encodes the Nf2/merlin tumor suppressor protein that is responsible for the regulation of cell proliferation. Once activated, Nf2/merlin modulates adhesive signaling pathways and thereby inhibits cell growth. Nf2/mer
Externí odkaz:
https://doaj.org/article/0725877ad4d24c64884cc948564098f4
Autor:
Krishna Chinthalapudi, Vinay Mandati, Jie Zheng, Andrew J. Sharff, Gerard Bricogne, Patrick R. Griffin, Joseph Kissil, Tina Izard
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Neurofibromin 2 (NF2) is a tumour suppressor that inhibits cell growth. Here the authors combine functional, biochemical, and structural studies and show that lipid-bound NF2 adopts an open conformation and that NF2 lipid binding is required for inhi
Externí odkaz:
https://doaj.org/article/6a39c45334a64f2096f37fa863eb2504
Autor:
Sonia Mediouni, Krishna Chinthalapudi, Mary K. Ekka, Ippei Usui, Joseph A. Jablonski, Mark A. Clementz, Guillaume Mousseau, Jason Nowak, Venkat R. Macherla, Jacob N. Beverage, Eduardo Esquenazi, Phil Baran, Ian Mitchelle S. de Vera, Douglas Kojetin, Erwann P. Loret, Kendall Nettles, Souvik Maiti, Tina Izard, Susana T. Valente
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT The intrinsically disordered HIV-1 Tat protein binds the viral RNA transactivation response structure (TAR), which recruits transcriptional cofactors, amplifying viral mRNA expression. Limited Tat transactivation correlates with HIV-1 latenc
Externí odkaz:
https://doaj.org/article/602de632323a423fab4a3dba4bf5eaf7
Autor:
Dipak N Patil, Erumbi S Rangarajan, Scott J Novick, Bruce D Pascal, Douglas J Kojetin, Patrick R Griffin, Tina Izard, Kirill A Martemyanov
Publikováno v:
eLife, Vol 7 (2018)
Signaling by the G-protein-coupled receptors (GPCRs) plays fundamental role in a vast number of essential physiological functions. Precise control of GPCR signaling requires action of regulators of G protein signaling (RGS) proteins that deactivate h
Externí odkaz:
https://doaj.org/article/962c46922f7d4f05b29c977d8954fda6
Autor:
Dipak N. Patil, Shikha Singh, Thibaut Laboute, Timothy S. Strutzenberg, Xingyu Qiu, Di Wu, Scott J. Novick, Carol V. Robinson, Patrick R. Griffin, John F. Hunt, Tina Izard, Appu K. Singh, Kirill A. Martemyanov
Publikováno v:
Science
Not your typical GPCR Among the large family of G protein–coupled receptors (GPCRs) are many orphans, so called because their signaling reactions remain poorly understood. Among these is GPR158 which is highly expressed in the nervous system and im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493ed2eac91bdbd9a1a19a0ab84f5be4
https://pubmed.ncbi.nlm.nih.gov/34793198
https://pubmed.ncbi.nlm.nih.gov/34793198
Autor:
Annachiara Tinivella, Jerome C. Nwachukwu, Andrea Angeli, Francesca Foschi, Anna Laura Benatti, Luca Pinzi, Tina Izard, Marta Ferraroni, Rangarajan Erumbi, Michael S. Christodoulou, Daniele Passarella, Claudiu T. Supuran, Kendall W. Nettles, Giulio Rastelli
Multi-target compounds have become increasingly important for the development of safer and more effective drug candidates. In this work, we devised a combined ligand-based and structure-based multi-target repurposing strategy and applied it to a seri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d95372c0181bc29de0bfea1d3aab9c0
https://hdl.handle.net/11380/1301667
https://hdl.handle.net/11380/1301667
Autor:
Marina Candido Primi, Tina Izard, Larry L. Klein, Carlos Mauricio R. Sant'Anna, Mauricio Temotheo Tavares, Elizabeth Igne Ferreira, Scott G. Franzblau
Publikováno v:
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
Background: Tuberculosis (TB) has been a challenging disease worldwide, especially for the neglected poor populations. Presently, there are approximately 2 billion people infected with TB worldwide and 10 million people in the world fell ill with act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2479c996da3d6782acee8b801432c7f7
https://doi.org/10.2174/1568026621666210728094804
https://doi.org/10.2174/1568026621666210728094804