Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Tina, Garyantes"'
Autor:
Sapna Patel, Alain Mita, Kyriakos P Papadopoulos, Justine Cohen, Alexander Shoushtari, Jordi Rodon, Marlana Orloff, Marya Chaney, Carolyn Muller, Jessica Lin, Tina Garyantes, Monica Mita, Christopher Natale, Jeffrey Ishizuka
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/eea4b5f77786436a94e0b9b2b34ee5b4
Publikováno v:
Cancer Research Communications. 3:540-547
Uveal melanoma is the most common primary intraocular malignancy in adults and has a high incidence of metastatic disease. Current treatments have shown limited clinical activity in patients with uveal melanoma with metastasis and there is an urgent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::288b181a3f50e249fb0787a14455d821
https://doi.org/10.1158/2767-9764.crc-22-0399
https://doi.org/10.1158/2767-9764.crc-22-0399
Uveal melanoma is the most common primary intraocular malignancy in adults and has a high incidence of metastatic disease. Current treatments have shown limited clinical activity in patients with uveal melanoma with metastasis and there is an urgent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69afe8ba6bb19a03167b066d7058cef
https://doi.org/10.1158/2767-9764.c.6551254.v2
https://doi.org/10.1158/2767-9764.c.6551254.v2
The mitotic effect of LNS8801 is GPER-independent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d50a93a1ef555132a3ea3f3be41b48e
https://doi.org/10.1158/2767-9764.22561165
https://doi.org/10.1158/2767-9764.22561165
Autor:
Yanlin Wang-Fischer, Tina Garyantes
Publikováno v:
Journal of Diabetes Research, Vol 2018 (2018)
The Streptozotocin- (STZ-) induced diabetic model is widely used; however, unexplained acute toxicity has given the model an unreliable reputation. To improve the reliability and utility of this model, we characterize the age dependence of STZ toxici
Externí odkaz:
https://doaj.org/article/4aadb81833cf43b894005a988efbf902
Autor:
Jordi Rodon, Marya Chaney, Justine Cohen, Tina Garyantes, Jessica Lin, Patricia Lorusso, Alain Mita, Monica Mita, Carolyn Muller, Christopher Natale, Marlana Orloff, Kyriakos Papadopoulos, Sapna Patel
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::587ec8e683d52e0db87a57d2c9abb049
https://doi.org/10.1136/jitc-2022-sitc2022.0759
https://doi.org/10.1136/jitc-2022-sitc2022.0759
Publikováno v:
Cancer Research. 81:1225-1225
Women have a lower incidence of and improved clinical outcomes for most cancer types, but the mechanistic basis for this sex difference is unknown. We hypothesized that estrogen signaling may be responsible, despite the fact that many cancer types la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb67f7bb0685dd0a7d690e7c23fb84f1
https://doi.org/10.1158/1538-7445.am2021-1225
https://doi.org/10.1158/1538-7445.am2021-1225
Autor:
Chris Natale, Tina Garyantes
Publikováno v:
Cancer Research. 81:1282-1282
LNS8801 is the first-in-class, small molecule, orally bioavailable, agonist of GPER being developed for the treatment of patients with advanced cancer. LNS8801 is highly selective for GPER over the classical nuclear hormone estrogen receptors α and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d71e78fcc0648cedcaf97ec86213464
https://doi.org/10.1158/1538-7445.am2021-1282
https://doi.org/10.1158/1538-7445.am2021-1282
Autor:
Tina Garyantes, Carolyn Y. Muller, Ursa Brown-Glaberman, Emrullah Yilmaz, Marya F. Chaney, Takami Sato, Patricia LoRusso, Alain C. Mita, Marlana Orloff, Jennifer L. McQuade, Jordi Rodon, Christopher Natale, Monica M. Mita, Kyriakos P. Papadopoulos
Publikováno v:
Journal of Clinical Oncology. 39:3084-3084
3084 Background: The G protein-coupled estrogen receptor (GPER) is a broadly expressed G protein-coupled receptor that is tumor suppressive. LNS8801 is an oral, highly selective small molecule agonist of GPER. GPER activation results in c-Myc depleti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57b194bfec63c441595cd2d2aa385d69
https://doi.org/10.1200/jco.2021.39.15_suppl.3084
https://doi.org/10.1200/jco.2021.39.15_suppl.3084
Autor:
G. Sitta Sittampalam, Robert P. Hertzberg, William P. Janzen, Dragan A. Cirovic, Ricardo Macarron, David J. Burns, Tina Garyantes, Martyn Banks, Darren V. S. Green, Jeff W. Paslay, Dejan Bojanic, Ulrich Schopfer
Publikováno v:
Nature Reviews Drug Discovery. 10:188-195
High-throughput screening (HTS) has been postulated in several quarters to be a contributory factor to the decline in productivity in the pharmaceutical industry. Moreover, it has been blamed for stifling the creativity that drug discovery demands. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d0f5fd05d9f368f1dc535c4360ed993
https://doi.org/10.1038/nrd3368
https://doi.org/10.1038/nrd3368