Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Tin T. Truong"'
Autor:
Giuseppe Deganutti, Yi-Lynn Liang, Xin Zhang, Maryam Khoshouei, Lachlan Clydesdale, Matthew J. Belousoff, Hari Venugopal, Tin T. Truong, Alisa Glukhova, Andrew N. Keller, Karen J. Gregory, Katie Leach, Arthur Christopoulos, Radostin Danev, Christopher A. Reynolds, Peishen Zhao, Patrick M. Sexton, Denise Wootten
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The glucagon-like peptide-1 receptor (GLP-1R) can be targeted in the treatment of diabetes, obesity and other metabolic disorders. Here, the authors assess the molecular mechanisms of peptide agonists binding to GLP-1R and the responses elucidated by
Externí odkaz:
https://doaj.org/article/8f7e8894b23a4f8eb32f5d2c26ccefc6
Autor:
Lachlan Clydesdale, Hari Venugopal, Peishen Zhao, Patrick M. Sexton, Alisa Glukhova, Arthur Christopoulos, Christopher A. Reynolds, Yi Lynn Liang, Xin Zhang, Tin T. Truong, Andrew N. Keller, Maryam Khoshouei, Matthew J. Belousoff, Karen J. Gregory, Giuseppe Deganutti, Radostin Danev, Denise Wootten, Katie Leach
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Nature Communications
Nature Communications
The glucagon-like peptide-1 receptor (GLP-1R) has broad physiological roles and is a validated target for treatment of metabolic disorders. Despite recent advances in GLP-1R structure elucidation, detailed mechanistic understanding of how different p
Publikováno v:
Biochemical pharmacology. 199
G protein-coupled receptors (GPCRs) are the largest class of membrane proteins and in recent years there has been a growing appreciation of the importance in understanding temporal aspects of GPCR behaviour, including the kinetics of ligand binding a
Autor:
Brian P. Cary, Giuseppe Deganutti, Peishen Zhao, Tin T. Truong, Sarah J. Piper, Xinyu Liu, Matthew J. Belousoff, Radostin Danev, Patrick M. Sexton, Denise Wootten, Samuel H. Gellman
Publikováno v:
Nat Chem Biol
Recent advances in G protein-coupled receptor (GPCR) structural elucidation have strengthened previous hypotheses that multi-dimensional signal propagation mediated by these receptors depends, in part, on their conformational mobility. However, the r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d01469e99ce925a839a3429360abd3
https://europepmc.org/articles/PMC8950777/
https://europepmc.org/articles/PMC8950777/
Autor:
Kathleen M. Caron, Duncan I. Mackie, Asuka Inoue, Denise Wootten, John B. Pawlak, Mark Soave, Matthew Harris, Ho Yan Yeung, Suleiman Al-Sabah, Matthew T. Harper, Stephen J. Briddon, Graham Ladds, Peishen Zhao, Sabrina Carvalho, Dewi Safitri, Patrick M. Sexton, David R. Poyner, Sarah J Routledge, Stephen J. Hill, Bashaier Al-Zaid, Tin T. Truong
Gastric inhibitory polypeptide (GIP) receptor is a class B1 GPCR, that responds to GIP and physiologically potentiates glucose-stimulated insulin secretion. Like most class B1 GPCRs, GIPR has been shown to interact with RAMPs, yet the effects of RAMP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54cc5ceea92e5fc39a1bfce8ebe510e2
https://doi.org/10.1101/2021.04.08.436756
https://doi.org/10.1101/2021.04.08.436756
Autor:
Patrick M. Sexton, Peishen Zhao, Brian P. Cary, Samuel H. Gellman, Tin T. Truong, Sarah J. Piper, Radostin Danev, Matthew J. Belousoff, Denise Wootten
Recent advances in G protein-coupled receptor (GPCR) structural elucidation have strengthened previous hypotheses that multi-dimensional signal propagation mediated by these receptors is, in part, dependent on their conformational mobility. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::486b30e25a8b70513dc258d20de247a6
https://doi.org/10.1101/2021.02.24.432589
https://doi.org/10.1101/2021.02.24.432589
Autor:
Thomas Kruse, Patrick M. Sexton, Trine R. Clausen, Grace Mennen, Tin T. Truong, Denise Wootten, Peter Keov, Peishen Zhao, Sebastian Gb Furness, Madeleine M. Fletcher, Caroline A. Hick
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 377(3)
Obesity and associated comorbidities are a major health burden, and novel therapeutics to help treat obesity are urgently needed. There is increasing evidence that targeting the amylin receptors (AMYRs), heterodimers of the calcitonin G protein-coupl
Autor:
Thomas Egebjerg, Steffen Reedtz-Runge, Christopher J. Langmead, Hari Venugopal, Peishen Zhao, Sheng Y. Ang, Radostin Danev, Patrick M. Sexton, Gregory D. Stewart, David E. Gloriam, Alisa Glukhova, Tin T. Truong, Sebastian G.B. Furness, Christina Rye Underwood, Xin Zhang, Albert J. Kooistra, Laurence J. Miller, Arthur Christopoulos, Petr Šenel, Yi Lynn Liang, Matthew J. Belousoff, Denise Wootten
Publikováno v:
Zhang, X, Belousoff, M J, Zhao, P, Kooistra, A J, Truong, T T, Ang, S Y, Underwood, C R, Egebjerg, T, Šenel, P, Stewart, G D, Liang, Y-L, Glukhova, A, Venugopal, H, Christopoulos, A, Furness, S G B, Miller, L J, Reedtz-Runge, S, Langmead, C J, Gloriam, D E, Danev, R, Sexton, P M & Wootten, D 2020, ' Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists ', Molecular Cell, vol. 80, no. 3, pp. 485-500 . https://doi.org/10.1016/j.molcel.2020.09.020
Peptide drugs targeting class B1 G-protein-coupled receptors (GPCRs) can treat multiple diseases; however, there remains substantial interest in the development of orally delivered non-peptide drugs. Here, we reveal unexpected overlap between signali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf3e93793c5fecfb5c14acdfc4376a4
https://curis.ku.dk/portal/da/publications/differential-glp1r-binding-and-activation-by-peptide-and-nonpeptide-agonists(d15f7c32-33ae-43b2-9d9d-b3809a50eb78).html
https://curis.ku.dk/portal/da/publications/differential-glp1r-binding-and-activation-by-peptide-and-nonpeptide-agonists(d15f7c32-33ae-43b2-9d9d-b3809a50eb78).html
Autor:
Denise Wootten, Tin T. Truong, Saifei Lei, Ming-Wei Wang, Arthur Christopoulos, Wolfgang Baumeister, Lachlan Clydesdale, Yi Lynn Liang, Cassandra Koole, Laurence J. Miller, David M. Thal, Patrick M. Sexton, Mazdak Radjainia, Alisa Glukhova, Peishen Zhao, Sebastian G.B. Furness, Maryam Khoshouei, Radostin Danev
Publikováno v:
Nature. 555:121-125
The class B glucagon-like peptide-1 (GLP-1) G protein-coupled receptor is a major target for the treatment of type 2 diabetes and obesity. Endogenous and mimetic GLP-1 peptides exhibit biased agonism-a difference in functional selectivity-that may pr
Autor:
Patricia McDonald, Matthew R. Pratt, Eileen J. Daley, Aaron T. Balana, Hiroshi Noda, Emmanuel Sturchler, Tin T. Truong, Patrick M. Sexton, Barbara Zarzycka, Thomas J. Gardella, Denise Wootten, Vsevolod Katritch, Paul M. Levine, Cassandra Koole
Publikováno v:
J Am Chem Soc
Peptide agonists of GPCRs and other receptors are powerful signaling molecules with high potential as biological tools and therapeutics, but they are typically plagued by instability and short half-lives in vivo. Nature uses protein glycosylation to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f165c990ce91342cf6b3b2eb7b6ba8a
https://europepmc.org/articles/PMC6860926/
https://europepmc.org/articles/PMC6860926/