Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Tin Lap Lee"'
Autor:
Hue M. La, Jinyue Liao, Julien M. D. Legrand, Fernando J. Rossello, Ai-Leen Chan, Vijesh Vaghjiani, Jason E. Cain, Antonella Papa, Tin Lap Lee, Robin M. Hobbs
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Male germline regeneration after damage is dependent on spermatogonial stem cells (SSCs) but pathways mediating the regenerative response are unclear. Here the authors define roles for growth factor signalling and mTORC1 in SSC-driven regeneration.
Externí odkaz:
https://doaj.org/article/c5b786b3253b4ddfa4628cd3bcff83d1
Autor:
Heather K. Mak, Jasmine S.Y. Yung, Robert N. Weinreb, Shuk Han Ng, Xu Cao, Tracy Y.C. Ho, Tsz Kin Ng, Wai Kit Chu, Wing Ho Yung, Kwong Wai Choy, Chi Chiu Wang, Tin Lap Lee, Christopher Kai-shun Leung
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 21, Iss , Pp 251-263 (2020)
Irreversible blindness from glaucoma and optic neuropathies is attributed to retinal ganglion cells (RGCs) losing the ability to regenerate axons. While several transcription factors and proteins have demonstrated enhancement of axon regeneration aft
Externí odkaz:
https://doaj.org/article/c2641bf020c944a1ae875a4685a62fa6
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e83980 (2013)
MicroRNA-199a (miRNA-199a) has been shown to have comprehensive functions and behave differently in different systems and diseases. It is encoded by two loci in the human genome, miR-199a-1 in chromosome 19 and miR-199a-2 in chromosome 1. Both loci g
Externí odkaz:
https://doaj.org/article/fd33774b6ed44050a641554d017ad527
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Despite aging is closely linked to increased aneuploidy in the oocytes, the mechanism of how aging affects aneuploidy remains largely elusive. Here, we applied single-cell parallel methylation and transcriptome sequencing (scM&T-seq) data fr
Externí odkaz:
https://doaj.org/article/28fdcabdf16840ceaa11e47c379ba8a7
Smad3 is essential for polarization of tumor-associated neutrophils in non-small cell lung carcinoma
Autor:
Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Max Kam-Kwan Chan, Vivian Weiwen Xue, Xiao-Ru Huang, Calvin Sze-Hang Ng, Dongmei Zhang, Kam-Tong Leung, Chun-Kwok Wong, Tin-Lap Lee, Eric W-F Lam, David J. Nikolic-Paterson, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
TGF-β stimulated tumor-associated neutrophils (TANs) can exert pro-tumoral functions. Here the authors show that Smad3 activation in TANs is associated with an N2-like polarization state and poor outcome in patients with non-small cell lung carcinom
Externí odkaz:
https://doaj.org/article/ba3ca05e7ec94b9aa2d7bbddfdfd4bef
Autor:
Hoi Ching Suen, Shitao Rao, Alfred Chun Shui Luk, Ruoyu Zhang, Lele Yang, Huayu Qi, Hon Cheong So, Robin M Hobbs, Tin-lap Lee, Jinyue Liao
Publikováno v:
eLife, Vol 12 (2023)
Spermatogenesis depends on an orchestrated series of developing events in germ cells and full maturation of the somatic microenvironment. To date, the majority of efforts to study cellular heterogeneity in testis has been focused on single-cell gene
Externí odkaz:
https://doaj.org/article/04602df871d347c3b7e92576a8ec5dc5
Autor:
Murong Xu, Mingpeng Zhao, Raymond Hang Wun Li, Zhixiu Lin, Jacqueline Pui Wah Chung, Tin Chiu Li, Tin-Lap Lee, David Yiu Leung Chan
Publikováno v:
Reproduction and Fertility, Vol 3, Iss 1, Pp R19-R33 (2022)
Objective: To summarize the currently available phase I and II clinical trials of the effects of nonoxynol-9 (N-9) on human sperm structure and functions. Methods: A systematic review and meta-analysis aiming to evaluate the spermicidal activity of N
Externí odkaz:
https://doaj.org/article/f928d323d5d14aa895d65c05b9cbff14
Autor:
Philip Chiu‐Tsun Tang, Jeff Yat‐Fai Chung, Vivian Wei‐wen Xue, Jun Xiao, Xiao‐Ming Meng, Xiao‐Ru Huang, Shuang Zhou, Alex Siu‐Wing Chan, Anna Chi‐Man Tsang, Alfred Sze‐Lok Cheng, Tin‐Lap Lee, Kam‐Tong Leung, Eric W.‐F. Lam, Ka‐Fai To, Patrick Ming‐Kuen Tang, Hui‐Yao Lan
Publikováno v:
Advanced Science, Vol 9, Iss 1, Pp n/a-n/a (2022)
Abstract Cancer‐associated fibroblasts (CAFs) are important in tumor microenvironment (TME) driven cancer progression. However, CAFs are heterogeneous and still largely underdefined, better understanding their origins will identify new therapeutic
Externí odkaz:
https://doaj.org/article/88a2b3b2105e4c93a1fe6c6dfeb41b23
Autor:
Jinyue Liao, Hoi Ching Suen, Alfred Chun Shui Luk, Lele Yang, Annie Wing Tung Lee, Huayu Qi, Tin-Lap Lee
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009369 (2021)
Spermatogonial stem cells (SSC), the foundation of spermatogenesis and male fertility, possess lifelong self-renewal activity. Aging leads to the decline in stem cell function and increased risk of paternal age-related genetic diseases. In the presen
Externí odkaz:
https://doaj.org/article/c278e779c81a487ebacd9f1d601ef7d4
Autor:
Benny Abraham Kaipparettu, Yewei Ma, Jun Hyoung Park, Tin-Lap Lee, Yiqun Zhang, Patricia Yotnda, Chad J Creighton, Wai-Yee Chan, Lee-Jun C Wong
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0221671 (2019)
[This corrects the article DOI: 10.1371/journal.pone.0061747.].
Externí odkaz:
https://doaj.org/article/9a2532d08fda46968ef88806ae091664