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Autor:
Jonathan S, Foot, Alberto, Buson, Mandar, Deodhar, Alison D, Findlay, Alan D, Robertson, Craig I, Turner, Tin, Yow, Wenbin, Zhou, Wolfgang, Jarolimek
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 74:128942
The discovery of a dual MAO-B/SSAO inhibitor PXS-5131 is reported. The compound offers a compact and rigid three-dimensional structure with superior selectivity over MAO-A. Potency and selectivity are linked to both the double bond geometry and stere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4c64f7cbe0681ee40033a81278070c
https://doi.org/10.1016/j.bmcl.2022.128942
https://doi.org/10.1016/j.bmcl.2022.128942
