Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Timur Zilbershtein"'
Publikováno v:
Applied Catalysis A: General. 475:371-378
Decene formation in the ethylene trimerization reaction was studied using a chromium(III) 2-ethylhexanoate/2,5-dimethylpyrrole/triethylaluminum/diethylaluminum chloride catalyst system. Kinetic investigations revealed that some decene formation react
Publikováno v:
Petroleum Chemistry. 52:253-260
It has been found that the activity of a catalyst for selective oligomerization (trimerization) of ethylene based on a chromium salt and organoaluminum compounds (OACs) can be substantially enhanced by the microwave irradiation of organoaluminum comp
Autor:
Nevena Mollova, Alexei V. Ivanov, Ian Henderson, Parkhill Eric Q, Jeffrey Chisholm, Kwan Leung, Andrew G. Cole, Sandra A. Brunn, Andrei Glushkov, Dmitry Koltun, Natalya I. Vasilevich, Nathan A. Zautke, Timur Zilbershtein, Jeff Zablocki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2048-2052
We identified a series of structurally novel SCD (Delta9 desaturase) inhibitors via high-throughput screening and follow-up SAR studies. Modification of the central bicyclic scaffold has proven key to our potency optimization effort. The most potent
Autor:
Ian Henderson, Jeffrey Chisholm, Nathan A. Zautke, Melanie Boze, Jia Hao, Timur Zilbershtein, Natalya I. Vasilevich, Dmitry Koltun, Jeff Zablocki, Elena Mayboroda, Andrei Glushkov, Sandra A. Brunn, Nancy Chu, Parkhill Eric Q, Kwan Leung, Andrew G. Cole, Nevena Mollova
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(11)
We discovered a structurally novel SCD (Delta9 desaturase) inhibitor 4a (CVT-11,563) that has 119 nM potency in a human cell-based (HEPG2) SCD assay and selectivity against Delta5 and Delta6 desaturases. This compound has 90% oral bioavailability (ra