Sialidase neu4 deficiency is associated with neuroinflammation in mice.

Autor: Timur ZK; Department of Molecular Biology and Genetics, Izmir Institute of Technology, Urla, Izmir, Turkey., Inci OK; Department of Molecular Biology and Genetics, Izmir Institute of Technology, Urla, Izmir, Turkey., Demir SA; Izmir Institute of Technology, IYTEDEHAM, Urla, İzmir, Turkey., Seyrantepe V; Department of Molecular Biology and Genetics, Izmir Institute of Technology, Urla, Izmir, Turkey. volkanseyrantepe@iyte.edu.tr.; Izmir Institute of Technology, IYTEDEHAM, Urla, İzmir, Turkey. volkanseyrantepe@iyte.edu.tr.

Publikováno v: Glycoconjugate journal [Glycoconj J] 2021 Dec; Vol. 38 (6), pp. 649-667. Date of Electronic Publication: 2021 Oct 23.

Murine Sialidase Neu3 facilitates GM2 degradation and bypass in mouse model of Tay-Sachs disease.

Autor: Seyrantepe V; Department of Molecular Biology and Genetics, Izmir Institute of Technology, 35430 Izmir, Turkey. Electronic address: volkanseyrantepe@iyte.edu.tr., Demir SA; Department of Molecular Biology and Genetics, Izmir Institute of Technology, 35430 Izmir, Turkey., Timur ZK; Department of Molecular Biology and Genetics, Izmir Institute of Technology, 35430 Izmir, Turkey., Von Gerichten J; Lipid Pathobiochemistry Group (G131) German Cancer Research Center, INF 280, 69120 Heidelberg, Germany., Marsching C; Lipid Pathobiochemistry Group (G131) German Cancer Research Center, INF 280, 69120 Heidelberg, Germany; Center for Applied Research in Applied Biomedical Mass Spectrometry (ABIMAS), Mannheim, Germany; Institute of Medical Technology (IMT) of Heidelberg University and Mannheim University of Applied Sciences, Paul-Wittsach-Str.10, 68163 Mannheim, Germany., Erdemli E; Departments of Histology and Embryology, Ankara University, Medical School, 06100, Sihhiye, Ankara, Turkey., Oztas E; Departments of Histology and Embryology, GATA Medical School, 06100 Ankara, Turkey., Takahashi K; Cell Recognition Study, Tohoku Pharmaceutical University, Sendai, Japan., Yamaguchi K; Miyagi Cancer Center Research Institute, Natori, Japan., Ates N; Department of Molecular Biology and Genetics, Izmir Institute of Technology, 35430 Izmir, Turkey., Dönmez Demir B; Institutes of Neurological Science and Psychiatry, University of Hacettepe, 06100 Ankara, Turkey., Dalkara T; Institutes of Neurological Science and Psychiatry, University of Hacettepe, 06100 Ankara, Turkey., Erich K; Center for Applied Research in Applied Biomedical Mass Spectrometry (ABIMAS), Mannheim, Germany; Institute of Medical Technology (IMT) of Heidelberg University and Mannheim University of Applied Sciences, Paul-Wittsach-Str.10, 68163 Mannheim, Germany., Hopf C; Center for Applied Research in Applied Biomedical Mass Spectrometry (ABIMAS), Mannheim, Germany; Institute of Medical Technology (IMT) of Heidelberg University and Mannheim University of Applied Sciences, Paul-Wittsach-Str.10, 68163 Mannheim, Germany., Sandhoff R; Lipid Pathobiochemistry Group (G131) German Cancer Research Center, INF 280, 69120 Heidelberg, Germany., Miyagi T; Miyagi Cancer Center Research Institute, Natori, Japan.

Publikováno v: Experimental neurology [Exp Neurol] 2018 Jan; Vol. 299 (Pt A), pp. 26-41. Date of Electronic Publication: 2017 Sep 30.

Neuraminidase-1 contributes significantly to the degradation of neuronal B-series gangliosides but not to the bypass of the catabolic block in Tay-Sachs mouse models.

Autor: Timur ZK; Izmir Institute of Technology, Department of Molecular Biology and Genetics, Izmir, Turkey., Akyildiz Demir S; Izmir Institute of Technology, Department of Molecular Biology and Genetics, Izmir, Turkey., Marsching C; Lipid Biochemistry Lab, Cancer Research Center, Heidelberg, Germany., Sandhoff R; Lipid Biochemistry Lab, Cancer Research Center, Heidelberg, Germany., Seyrantepe V; Izmir Institute of Technology, Department of Molecular Biology and Genetics, Izmir, Turkey.

Publikováno v: Molecular genetics and metabolism reports [Mol Genet Metab Rep] 2015 Aug 15; Vol. 4, pp. 72-82. Date of Electronic Publication: 2015 Aug 15 (Print Publication: 2015).