Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Timur Yusufzai"'
Autor:
Jia Zhou, Jany Chan, Marie Lambelé, Timur Yusufzai, Jason Stumpff, Patricia L. Opresko, Markus Thali, Susan S. Wallace
Publikováno v:
Cell Reports, Vol 20, Iss 9, Pp 2044-2056 (2017)
Oxidative damage to telomere DNA compromises telomere integrity. We recently reported that the DNA glycosylase NEIL3 preferentially repairs oxidative lesions in telomere sequences in vitro. Here, we show that loss of NEIL3 causes anaphase DNA bridgin
Externí odkaz:
https://doaj.org/article/a56c2275d4d641188cb095f3a57247cd
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e108066 (2014)
Loss of the chromatin remodeling ATPase CHD5 has been linked to the progression of neuroblastoma tumors, yet the underlying mechanisms behind the tumor suppressor role of CHD5 are unknown. In this study, we purified the human CHD5 complex and found t
Externí odkaz:
https://doaj.org/article/39c836d2c5d542afb4bb35246e3e1793
Autor:
Jason Stumpff, Marie Lambelé, Jia Zhou, Susan S. Wallace, Jany Chan, Timur Yusufzai, Markus Thali, Patricia L. Opresko
Publikováno v:
Cell Reports, Vol 20, Iss 9, Pp 2044-2056 (2017)
Summary Oxidative damage to telomere DNA compromises telomere integrity. We recently reported that the DNA glycosylase NEIL3 preferentially repairs oxidative lesions in telomere sequences in vitro. Here, we show that loss of NEIL3 causes anaphase DNA
Autor:
Emma A. Roberts, Emily F. Gaudiano, Heng Li, Karthikeyan Ponnienselvan, Kalindi Parmar, Kah Suan Lim, David Kozono, Ning Zheng, Connor Clairmont, Jessica Liu, Chunyu Yang, Alan D. D'Andrea, Timur Yusufzai, Larissa A. Sambel
BRCA1 deficient tumor cells have defects in homologous-recombination repair and in replication fork stability, resulting in PARP inhibitor sensitivity. Here, we demonstrate that a deubiquitinase, USP1, is upregulated in tumors with mutations in BRCA1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d825d53ae5a16e453497fffb914bb2be
https://europepmc.org/articles/PMC6390489/
https://europepmc.org/articles/PMC6390489/
Autor:
Rodolfo Bortolozo Serafim, Catarina G. Ferreira, Timur Yusufzai, Brendan D. Price, Jiaqi Li, Kathryn A. Coe, Steven Ketchum, Jia Zhou, Jessica Liu
Publikováno v:
Nucleic Acids Research
CHD1 is a conserved chromatin remodeling enzyme required for development and linked to prostate cancer in adults, yet its role in human cells is poorly understood. Here, we show that targeted disruption of the CHD1 gene in human cells leads to a defe
Autor:
Raphael Ceccaldi, Alan D. D'Andrea, Jessica Liu, Ildiko Hajdu, Stephen J. Elledge, Simon J. Boulton, Ravindra Amunugama, Panagiotis A. Konstantinopoulos, Timur Yusufzai, Kevin W O'Connor, Benjamin Primack, Mark I.R. Petalcorin
Publikováno v:
Nature. 518:258-262
Large-scale genomic studies have shown that half of epithelial ovarian cancers (EOCs) have alterations in genes regulating homologous recombination (HR) repair. Loss of HR accounts for the genomic instability of EOCs and for their cellular hyper-depe
Autor:
Timur Yusufzai, Benjamin J. Manning
Publikováno v:
The Journal of Biological Chemistry
Proper chromatin regulation is central to genome function and maintenance. The group III chromodomain–helicase–DNA-binding (CHD) family of ATP-dependent chromatin remodeling enzymes, comprising CHD6, CHD7, CHD8, and CHD9, has well-documented role
Publikováno v:
Nucleic acids research, 45(8)
Nucleic Acids Research
Nucleic Acids Research
We investigate the mechanistic nature of the Snf2 family protein HARP, mutations of which are responsible for Schimke immuno-osseous dysplasia. Using a single-molecule magnetic tweezers assay, we construct RPA-stabilized DNA bubbles within torsionall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd068b2a6f33bf1ffc0436fde512ab06
http://resolver.tudelft.nl/uuid:8ae629c1-d4c5-4cda-b4c0-e753fce69756
http://resolver.tudelft.nl/uuid:8ae629c1-d4c5-4cda-b4c0-e753fce69756
Autor:
Jinhua Quan, Timur Yusufzai
Publikováno v:
Journal of Biological Chemistry. 289:20717-20726
Although mutations or deletions of chromodomain helicase DNA-binding protein 5 (CHD5) have been linked to cancer and implicate CHD5 in tumor suppression, the ATP-dependent activity of CHD5 is currently unknown. In this study, we discovered that CHD5
Autor:
Jinhua Quan, Timur Yusufzai
Publikováno v:
Epigenetics
The HepA-related protein (HARP/SMARCAL1) is an ATP-dependent annealing helicase that is capable of rewinding DNA structures that are stably unwound due to binding of the single-stranded DNA (ssDNA)-binding protein Replication Protein A (RPA). HARP ha