Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Timur M. Yusufzai"'
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279 (24), pp.25381-25389. ⟨10.1074/jbc.M403121200⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2004, 279 (24), pp.25381-25389. ⟨10.1074/jbc.M403121200⟩
The T cell rearrangement of the T cell receptor (TCR) genes TCRalpha and delta is specifically regulated by a complex interplay between enhancer elements and chromatin structure. The alpha enhancer is active in T cells and drives TCRalpha recombinati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a97280ac1b31b1578c0677a333d594
https://doi.org/10.1074/jbc.m403121200
https://doi.org/10.1074/jbc.m403121200
Autor:
Timur M. Yusufzai, Gary Felsenfeld
Publikováno v:
Proceedings of the National Academy of Sciences. 101:8620-8624
The protein CTCF plays an essential role in the action of a widely distributed class of vertebrate enhancer-blocking insulators, of which the first example was found in a DNA sequence element, HS4, at the 5′ end of the chicken β-globin locus. HS4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9700488546d02b35af4286c82cbd4d6f
https://doi.org/10.1073/pnas.0402938101
https://doi.org/10.1073/pnas.0402938101
CTCF Tethers an Insulator to Subnuclear Sites, Suggesting Shared Insulator Mechanisms across Species
Publikováno v:
Molecular Cell. 13(2):291-298
Insulators can block an enhancer of one gene from activating a promoter on another nearby gene. Almost all described vertebrate insulators require binding of the regulatory protein CTCF for their activity. We show that CTCF copurifies with the nucleo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f9f6b0470594af03d29c369f069bba3
Autor:
Timur M. Yusufzai, Alan P. Wolffe
Publikováno v:
Nucleic Acids Research. 28:4172-4179
The neurodevelopmental disorder known as Rett syndrome has recently been linked to the methyl-CpG-binding transcriptional repressor, MeCP2. In this report we examine the consequences of these mutations on the function of MeCP2. The ability to bind sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e341cd2beedf2bfcb4c5e2678caf160
https://doi.org/10.1093/nar/28.21.4172
https://doi.org/10.1093/nar/28.21.4172
Publikováno v:
Molecular and cellular biology. 27(22)
The insulator element at the 5' end of the chicken beta-globin locus acts as a barrier, protecting transgenes against silencing effects of adjacent heterochromatin. We showed earlier that the transcription factor USF1 binds within the insulator and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150d4a38e4423fd3a06bc25fc2edcd7a
https://pubmed.ncbi.nlm.nih.gov/17846119
https://pubmed.ncbi.nlm.nih.gov/17846119
Autor:
Timur M. Yusufzai, R. Ghirlando, Frédérique Magdinier, Miklos Gaszner, Vesco Mutskov, Hideaki Tagami, Michael D. Litt, Catherine M. Farrell, Bonnie Burgess-Beusse, C. Jin, Gary Felsenfeld, Adam G. West, Yoshihiro Nakatani, S. Huang
Publikováno v:
Cold Spring Harbor Symposia on Quantitative Biology
Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Laboratory; 1999, 2004, 69, pp.245-250. ⟨10.1101/sqb.2004.69.245⟩
Cold Spring Harbor Symposia on Quantitative Biology, Cold Spring Harbor Laboratory; 1999, 2004, 69, pp.245-250. ⟨10.1101/sqb.2004.69.245⟩
International audience; Insulator elements were first described in Drosophila, but subsequent studies have shown that they are present in vertebrates as well (for review, see West et al. 2002). Over the past several years we have focused our attentio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee10a97e20fafa849fe871ce3322ba8
https://pubmed.ncbi.nlm.nih.gov/16117655
https://pubmed.ncbi.nlm.nih.gov/16117655
Publikováno v:
Biochemistry. 39(24)
We have investigated the properties of mutant forms of the methyl-CpG binding transcriptional repressor MeCP2 associated with Rett syndrome, a childhood neurodevelopmental disorder. We find that four Rett syndrome mutations at known sites within the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf02fa6acad92789048b6809acbba01
https://pubmed.ncbi.nlm.nih.gov/10852707
https://pubmed.ncbi.nlm.nih.gov/10852707
Publikováno v:
Molecular and cellular biology. 20(11)
Ionizing radiation (IR) exposure causes mammalian cells to undergo p53-dependent cell cycle arrest and/or apoptosis. The in vivo role of DNA-dependent protein kinase (DNA-PK) in the transduction of the DNA damage signal to p53 remains unresolved. To
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff70c3921e7eface891382d285d58221
https://pubmed.ncbi.nlm.nih.gov/10805749
https://pubmed.ncbi.nlm.nih.gov/10805749