Zobrazeno 1 - 10
of 56
pro vyhledávání: '"Timur A. Mavlyutov"'
Publikováno v:
Cell & Bioscience, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Background Elevated intraocular pressure (IOP) is a major risk factor for the development and progression of primary open angle glaucoma and is due to trabecular meshwork (TM) damage. Here, we investigate the role of an endogenous Toll-like
Externí odkaz:
https://doaj.org/article/2258a098015b423389a505186f84d995
Autor:
Huan Yang, Yingmei Fu, Xinying Liu, Pawan K. Shahi, Timur A. Mavlyutov, Jun Li, Annie Yao, Steven Z.-W. Guo, Bikash R. Pattnaik, Lian-Wang Guo
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-15 (2017)
Abstract Background Retinitis pigmentosa (RP) is the most common inherited retinal degenerative disease yet with no effective treatment available. The sigma-1 receptor (S1R), a ligand-regulated chaperone, emerges as a potential retina-protective ther
Externí odkaz:
https://doaj.org/article/565262f5267641ab9d9168716c7ea62b
Autor:
Uyen B. Chu, Timur A. Mavlyutov, Ming-Liang Chu, Huan Yang, Amanda Schulman, Christophe Mesangeau, Christopher R. McCurdy, Lian-Wang Guo, Arnold E. Ruoho
Publikováno v:
EBioMedicine, Vol 2, Iss 11, Pp 1806-1813 (2015)
The sigma-2 receptor (S2R) is a potential therapeutic target for cancer and neuronal diseases. However, the identity of the S2R has remained a matter of debate. Historically, the S2R has been defined as (1) a binding site with high affinity to 1,3-di
Externí odkaz:
https://doaj.org/article/a59889769470463ca1fb2549fc5cc67d
Publikováno v:
Journal of Pharmacological Sciences, Vol 127, Iss 1, Pp 10-16 (2015)
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease affecting spinal cord motoneurons (MN) with an associative connection to Frontotemporal Lobar Dementia (FTLD). The endoplasmic reticulum (ER) bound Sigma-1 Receptor (S1R) chaperone pr
Externí odkaz:
https://doaj.org/article/56edaf4cccef47c59584994d9a9342ed
Autor:
Stacy Curry, Sherri L Harris, Timur A. Mavlyutov, Colleen M McDowell, Anil K. Chauhan, Amanda Lenell Roberts, Tanisha E Perlmutter
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
Elevated intraocular pressure (IOP) is a major risk factor for the development and progression of primary open angle glaucoma and is due to trabecular meshwork (TM) damage, which leads to impaired aqueous humor outflow. Here, we explore a novel molec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1256c0d7d79d873f7b1ab5fb09742861
http://link.springer.com/article/10.1038/s41598-020-66756-6
http://link.springer.com/article/10.1038/s41598-020-66756-6
Autor:
Timur A. Mavlyutov, Jing Li, Xinying Liu, Hongtao Shen, Huan Yang, Christopher R. McCurdy, Bikash Pattnaik, Lian-Wang Guo
Publikováno v:
Genes. 13:2386
The structurally and genetically distinct sigma-1 receptor (S1R) and sigma-2 receptor (S2R) comprise a unique class of drug binding sites. Their alleles are associated with human diseases involving neuronal systems, such as age-related macular degene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4170d0ec9df37a80a81b48f674c14e5c
https://doi.org/10.3390/genes13122386
https://doi.org/10.3390/genes13122386
Autor:
Timur A, Mavlyutov, Megan S, Kuhn, Samer E, Bilal, Michael L, De Ieso, Anil K, Chauhan, W Daniel, Stamer, Colleen M, McDowell
Publikováno v:
Experimental Eye Research. 225:109249
Previously we identified B6.EDA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6204380db9ad1bca6a5c16cb8ea3e473
https://doi.org/10.1016/j.exer.2022.109249
https://doi.org/10.1016/j.exer.2022.109249
Autor:
Laura Restani, Rebecca Bresnahan, Alexander D. Fellows, Charlotte Leese, Thomas Binz, Giampietro Schiavo, Tina Henke, Bazbek Davletov, Matteo Caleo, Timur A. Mavlyutov, Deniz Simsek, Ciara Doran
Publikováno v:
Toxicon
Toxicon: X, Vol 5, Iss, Pp-(2020)
Toxicon: X, Vol 5, Iss, Pp-(2020)
Neurological diseases constitute a quarter of global disease burden and are expected to rise worldwide with the ageing of human populations. There is an increasing need to develop new molecular systems which can deliver drugs specifically into neuron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2382cea838747cce12007e42423a2429
http://europepmc.org/articles/PMC7043326
http://europepmc.org/articles/PMC7043326
Autor:
Ryan D. Makin, Colleen M. Cebulla, Tyler Heisler-Taylor, Huan Yang, Lian-Wang Guo, Hongtao Shen, Bradley D. Gelfand, Timur A. Mavlyutov, Jing Li
Publikováno v:
Cell Signal
The retinal pigment epithelium (RPE) is critical to the survival of the overlying photoreceptors. Subject to light exposure and active metabolism, the RPE and photoreceptors are particularly susceptible to oxidative damage that plays an important par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc25921d14da7757a8cee7cf24a33b92
https://doi.org/10.1016/j.cellsig.2021.110078
https://doi.org/10.1016/j.cellsig.2021.110078
Autor:
Timur A. Mavlyutov, Xinying Liu, Steven Z.-W. Guo, Pawan K Shahi, Bikash R. Pattnaik, Yingmei Fu, Annie Yao, Jun Li, Lian-Wang Guo, Huan Yang
Publikováno v:
Molecular Neurodegeneration, Vol 12, Iss 1, Pp 1-15 (2017)
Molecular Neurodegeneration
Molecular Neurodegeneration
Background Retinitis pigmentosa (RP) is the most common inherited retinal degenerative disease yet with no effective treatment available. The sigma-1 receptor (S1R), a ligand-regulated chaperone, emerges as a potential retina-protective therapeutic t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72381fb6bf4a2a5b4c1239f14b792869
http://link.springer.com/article/10.1186/s13024-017-0202-z
http://link.springer.com/article/10.1186/s13024-017-0202-z