Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Timur A Yorgan"'
Autor:
Gretl Hendrickx, Vere M Borra, Ellen Steenackers, Timur A Yorgan, Christophe Hermans, Eveline Boudin, Jérôme J Waterval, Ineke D C Jansen, Tolunay Beker Aydemir, Niels Kamerling, Geert J Behets, Christine Plumeyer, Patrick C D'Haese, Björn Busse, Vincent Everts, Martin Lammens, Geert Mortier, Robert J Cousins, Thorsten Schinke, Robert J Stokroos, Johannes J Manni, Wim Van Hul
Publikováno v:
PLoS Genetics, Vol 14, Iss 4, p e1007321 (2018)
Hyperostosis Cranialis Interna (HCI) is a rare bone disorder characterized by progressive intracranial bone overgrowth at the skull. Here we identified by whole-exome sequencing a dominant mutation (L441R) in SLC39A14 (ZIP14). We show that L441R ZIP1
Externí odkaz:
https://doaj.org/article/3da077da62934ead948a9885d5b022b5
Autor:
Laura J Brylka, Sina Köppert, Anne Babler, Beate Kratz, Bernd Denecke, Timur A Yorgan, Julia Etich, Ivan G Costa, Bent Brachvogel, Peter Boor, Thorsten Schinke, Willi Jahnen-Dechent
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0187030 (2017)
Fetuin-A / α2-Heremans-Schmid-glycoprotein (gene name Ahsg) is a systemic inhibitor of ectopic calcification. Due to its high affinity for calcium phosphate, fetuin-A is highly abundant in mineralized bone matrix. Foreshortened femora in fetuin-A-de
Externí odkaz:
https://doaj.org/article/62cab22045ab4a4f85867d3b621cc24c
Autor:
Friederike Behler-Janbeck, Anke Baranowsky, Timur A. Yorgan, Michelle Y. Jaeckstein, Anna Worthmann, Marceline M. Fuh, Karthikeyan Gunasekaran, Gisa Tiegs, Michael Amling, Thorsten Schinke, Joerg Heeren
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
Bone is a dynamic tissue that is constantly remodeled throughout adult life. Recently, it has been shown that bone turnover decreases shortly after food consumption. This process has been linked to the fermentation of non-digestible food ingredients
Externí odkaz:
https://doaj.org/article/8ae75f068f8046b7bb571f37fd7660ae
Autor:
Laura J. Brylka, Assil-Ramin Alimy, Miriam E. A. Tschaffon-Müller, Shan Jiang, Tobias Malte Ballhause, Anke Baranowsky, Simon von Kroge, Julian Delsmann, Eva Pawlus, Kian Eghbalian, Klaus Püschel, Astrid Schoppa, Melanie Haffner-Luntzer, David J. Beech, Frank Timo Beil, Michael Amling, Johannes Keller, Anita Ignatius, Timur A. Yorgan, Tim Rolvien, Thorsten Schinke
Publikováno v:
Bone Research, Vol 12, Iss 1, Pp 1-16 (2024)
Abstract Piezo proteins are mechanically activated ion channels, which are required for mechanosensing functions in a variety of cell types. While we and others have previously demonstrated that the expression of Piezo1 in osteoblast lineage cells is
Externí odkaz:
https://doaj.org/article/a1586c2aa5be4762bf608a21489eff44
Autor:
Tobias Malte Ballhause, Shan Jiang, Weixin Xie, Jan Sevecke, Christine Dowling, Tobias Dust, Sabine Brandt, Peter R. Mertens, Timur Alexander Yorgan, Thorsten Schinke, Karl-Heinz Frosch, Anke Baranowsky, Johannes Keller
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Notch signaling regulates cell fate in multiple tissues including the skeleton. Hajdu–Cheney-Syndrome (HCS), caused by gain-of-function mutations in the Notch2 gene, is a rare inherited disease featuring early-onset osteoporosis and increa
Externí odkaz:
https://doaj.org/article/c45cc3b3163f4ccabefb908697d784c8
Autor:
Paul Mieske, Julia Scheinpflug, Timur Alexander Yorgan, Laura Brylka, Rupert Palme, Ute Hobbiesiefken, Juliane Preikschat, Lars Lewejohann, Kai Diederich
Publikováno v:
Laboratory Animal Research, Vol 39, Iss 1, Pp 1-21 (2023)
Abstract Background Enrichment of home cages in laboratory experiments offers clear advantages, but has been criticized in some respects. First, there is a lack of definition, which makes methodological uniformity difficult. Second, there is concern
Externí odkaz:
https://doaj.org/article/223b220d07ea44f396711d66f4ad6062
Autor:
Antonia Donat, Shan Jiang, Weixin Xie, Paul Richard Knapstein, Lilly-Charlotte Albertsen, Judith Luisa Kokot, Jan Sevecke, Ruben Augustin, Denise Jahn, Timur Alexander Yorgan, Karl-Heinz Frosch, Serafeim Tsitsilonis, Anke Baranowsky, Johannes Keller
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107761- (2023)
Summary: Impaired fracture healing is of high clinical relevance, as up to 15% of patients with long-bone fractures display non-unions. Fracture patients also include individuals treated with selective norepinephrine reuptake inhibitors (SNRI). As SN
Externí odkaz:
https://doaj.org/article/3a945e1785104d0bb97697744e0f6340
Autor:
Nele Vollersen, Wenbo Zhao, Tim Rolvien, Fabiola Lange, Felix Nikolai Schmidt, Stephan Sonntag, Doron Shmerling, Simon von Kroge, Kilian Elia Stockhausen, Ahmed Sharaf, Michaela Schweizer, Meliha Karsak, Björn Busse, Ernesto Bockamp, Oliver Semler, Michael Amling, Ralf Oheim, Thorsten Schinke, Timur Alexander Yorgan
Publikováno v:
Bone Research, Vol 9, Iss 1, Pp 1-13 (2021)
Abstract The recent identification of homozygous WNT1 mutations in individuals with osteogenesis imperfecta type XV (OI-XV) has suggested that WNT1 is a key ligand promoting the differentiation and function of bone-forming osteoblasts. Although such
Externí odkaz:
https://doaj.org/article/dec15195222f43c6a21a6c77c8ffa7fd
Autor:
Maximilian M. Delsmann, Jonathan Peichl, Timur A. Yorgan, Frank Timo Beil, Michael Amling, Marie B. Demay, Tim Rolvien
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Intact mineralization of the auditory ossicles - the smallest bones in the body - is essential for sound transmission in the middle ear, while ossicular hypomineralization is associated with conductive hearing loss. Here, we performed a high-resoluti
Externí odkaz:
https://doaj.org/article/dd8910bc725d42c49340276b64b1d2db
Autor:
Lena Marie Westermann, Lutz Fleischhauer, Jonas Vogel, Zsuzsa Jenei-Lanzl, Nataniel Floriano Ludwig, Lynn Schau, Fabio Morellini, Anke Baranowsky, Timur A. Yorgan, Giorgia Di Lorenzo, Michaela Schweizer, Bruna de Souza Pinheiro, Nicole Ruas Guarany, Fernanda Sperb-Ludwig, Fernanda Visioli, Thiago Oliveira Silva, Jamie Soul, Gretl Hendrickx, J. Simon Wiegert, Ida V. D. Schwartz, Hauke Clausen-Schaumann, Frank Zaucke, Thorsten Schinke, Sandra Pohl, Tatyana Danyukova
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 11 (2020)
Mucolipidosis type III (MLIII) gamma is a rare inherited lysosomal storage disorder caused by mutations in GNPTG encoding the γ-subunit of GlcNAc-1-phosphotransferase, the key enzyme ensuring proper intracellular location of multiple lysosomal enzym
Externí odkaz:
https://doaj.org/article/e0c2b4a6616e4ed9a97437fc0bf31230