Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Timsse Raj"'
Autor:
Meng Xu, Taku Ito-Kureha, Hyun-Seo Kang, Aleksandar Chernev, Timsse Raj, Kai P. Hoefig, Christine Hohn, Florian Giesert, Yinhu Wang, Wenliang Pan, Natalia Ziętara, Tobias Straub, Regina Feederle, Carolin Daniel, Barbara Adler, Julian König, Stefan Feske, George C. Tsokos, Wolfgang Wurst, Henning Urlaub, Michael Sattler, Jan Kisielow, F. Gregory Wulczyn, Marcin Łyszkiewicz, Vigo Heissmeyer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/9e89d380ba524171be8ac6b2c5c274ad
Autor:
Meng Xu, Taku Ito-Kureha, Hyun-Seo Kang, Aleksandar Chernev, Timsse Raj, Kai P. Hoefig, Christine Hohn, Florian Giesert, Yinhu Wang, Wenliang Pan, Natalia Ziętara, Tobias Straub, Regina Feederle, Carolin Daniel, Barbara Adler, Julian König, Stefan Feske, George C. Tsokos, Wolfgang Wurst, Henning Urlaub, Michael Sattler, Jan Kisielow, F. Gregory Wulczyn, Marcin Łyszkiewicz, Vigo Heissmeyer
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The regulation of thymocyte development by RNA-binding proteins (RBPs) is largely unexplored. We identify 642 RBPs in the thymus and focus on Arpp21, which shows selective and dynamic expression in early thymocytes. Arpp21 is downregulated i
Externí odkaz:
https://doaj.org/article/c1ccb1c3902a42deb7a8b59d19e9f6cb
Autor:
Jiahe Lu, Alisa Veler, Boris Simonetti, Timsse Raj, Po Han Chou, Stephen J. Cross, Alexander M. Phillips, Xiongtao Ruan, Lan Huynh, Andrew W. Dowsey, Dingwei Ye, Robert F. Murphy, Paul Verkade, Peter J. Cullen, Christoph Wülfing
Publikováno v:
Cells, Vol 12, Iss 21, p 2558 (2023)
T cells can express multiple inhibitory receptors. Upon induction of T cell exhaustion in response to a persistent antigen, prominently in the anti-tumor immune response, many are expressed simultaneously. Key inhibitory receptors are CTLA-4, PD-1, L
Externí odkaz:
https://doaj.org/article/ac243134714943f4b979a7673d47dd5c
Publikováno v:
Int. Immunol., DOI: 10.1093/intimm/dxac059 (2022)
The RNA-binding proteins Roquin-1/2 and Regnase-1 exert essential regulation by controlling pro-inflammatory mRNA expression to prevent autoimmune disease. More recently, inhibition of this post-transcriptional gene regulatory program has been demons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9c045440c25106a383054c028f1c54e
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66976
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=66976
Disrupting Roquin-1 interaction with Regnase-1 induces autoimmunity and enhances antitumor responses
Autor:
Stephanie L. Edelmann, Laura S. de Jonge, Lisa Kifinger, Wolfgang Wurst, Florian Giesert, Christine Hohn, Naoto Kawakami, Sebastian Theurich, Mingui Fu, Dierk Niessing, Nina Kronbeck, Martin E. Kirmaier, Vigo Heissmeyer, Timsse Raj, Thomas Monecke, Elena S. Davydova, Elaine H. Wong, Stefan Feske, Gesine Behrens, Mariano Gonzalez Pisfil
Publikováno v:
Nat Immunol
Nat. Immunol. 22, 1563-1576 (2021)
Nature immunology 22(12), 1563-1576 (2021). doi:10.1038/s41590-021-01064-3
Nat. Immunol. 22, 1563-1576 (2021)
Nature immunology 22(12), 1563-1576 (2021). doi:10.1038/s41590-021-01064-3
Roquin and Regnase-1 proteins bind and post-transcriptionally regulate proinflammatory target messenger RNAs to maintain immune homeostasis. Either the sanroque mutation in Roquin-1 or loss of Regnase-1 cause systemic lupus erythematosus-like phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c47294afa473dd395ea8a5b1a5695f3
https://europepmc.org/articles/PMC8996344/
https://europepmc.org/articles/PMC8996344/
Autor:
Andreas Maiser, Joao C. Guimaraes, Heinrich Leonhardt, Martin Hrabĕ de Angelis, Desheng Hu, Dirk Baumjohann, Anne Krug, Timsse Raj, Mihaela Zavolan, Stefan Floess, Alexander F. Heiseke, Jochen Huehn, Thomas Brocker, Juliane Klein, Susan Marschall, Katharina Essig, Vigo Heissmeyer, Elfriede Noessner, Dominik Alterauge, Cornelis F. Calkhoven, Stephanie L. Edelmann, Gesine Behrens, Jan Kranich
Publikováno v:
Immunity, 47(6), 1067-1082.e12. CELL PRESS
Roquin proteins preclude spontaneous T cell activation and aberrant differentiation of T follicular helper (Tfh) or T helper 17 (Th17) cells. Here we showed that deletion of Roquin-encoding alleles specifically in regulatory T (Treg) cells also cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ae816ab2d3554fdcd9fcda4fc49ee8
https://doi.org/10.1016/j.immuni.2017.11.008
https://doi.org/10.1016/j.immuni.2017.11.008