Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Timsi Rao"'
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Fowlpox virus resolvase (Fpr) is an endonuclease that cleaves a broad range of branched DNA structures, including the Holliday junction (HJ), with little sequence-specificity. To better understand the mechanisms underlying its relaxed substrate speci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86442f7bc25358f5af6412668e9c663b
http://link.springer.com/article/10.1038/s41598-019-56825-w
http://link.springer.com/article/10.1038/s41598-019-56825-w
Autor:
David G. Maranon, Weibin Wang, Xuemei Song, Fengshan Liang, Lucy Lu, Yong Xiong, Eric C. Greene, Xiaoyong Chen, Yanhong Deng, Gary M. Kupfer, Judit Jimenez-Sainz, Patrick Sung, Chen Sheng, Claudia Wiese, Timsi Rao, Chu Jian Ma, Youngho Kwon, Weixing Zhao, Justin B. Steinfeld, Ryan B. Jensen
Publikováno v:
Nature. 550:360-365
The tumour suppressor complex BRCA1-BARD1 functions in the repair of DNA double-stranded breaks by homologous recombination. During this process, BRCA1-BARD1 facilitates the nucleolytic resection of DNA ends to generate a single-stranded template for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01847945b57be45e2790ca9e8eb46f43
https://doi.org/10.1038/nature24060
https://doi.org/10.1038/nature24060
Autor:
Xiang Chen, Saeko Takada, Timsi Rao, Yves Pommier, Kylie J. Walters, Muthana Al Abo, Rui Gao, Hideki Aihara
Publikováno v:
Nucleic Acids Research
Tyrosyl DNA phosphodiesterase 2 (TDP2) is a multifunctional protein implicated in DNA repair, signal transduction and transcriptional regulation. In its DNA repair role, TDP2 safeguards genome integrity by hydrolyzing 5'-tyrosyl DNA adducts formed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ee02a930c6de11b553a5d97d77bcbd
http://europepmc.org/articles/PMC5137425
http://europepmc.org/articles/PMC5137425
Autor:
Allison M. Green, Yong Xiong, Xiaoyong Chen, Timsi Rao, Jingchun Liu, Patrick Sung, Simonne Longerich, Fengshan Liang, Natalie B. Collins, Gary M. Kupfer, Zhuobin Liang, Li Lan, Yaqun Teng
Publikováno v:
Cell reports
SUMMARY Fanconi anemia (FA) is characterized by developmental abnormalities, bone marrow failure, and cancer predisposition. FA cells are hypersensitive to DNA replicative stress and accumulate co-transcriptional R-loops. Here, we use the Damage At R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba353844fe76f2ed7640ef5de14b33f5
https://pubmed.ncbi.nlm.nih.gov/30650351
https://pubmed.ncbi.nlm.nih.gov/30650351
Publikováno v:
DNA Repair
SUMMARYFanconi-associated nuclease 1 (FAN1) removes interstrand DNA crosslinks (ICLs) through its DNA flap endonuclease and exonuclease activities. Crystal structures of human and bacterial FAN1 bound to a DNA flap have been solved. The Pseudomonas a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6de883e2109d35329d10c55635468ba3
https://pubmed.ncbi.nlm.nih.gov/29518739
https://pubmed.ncbi.nlm.nih.gov/29518739
Publikováno v:
Genetics. 193:715-725
Mutations that confer the loss of a single biochemical property (separation-of-function mutations) can often uncover a previously unknown role for a protein in a particular biological process. However, most mutations are identified based on loss-of-f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb3cdf28482efa7be362cfc1d4bb5310
https://doi.org/10.1534/genetics.112.147801
https://doi.org/10.1534/genetics.112.147801
Publikováno v:
Proceedings of the National Academy of Sciences. 107:12570-12575
Although mammalian polypyrimidine tract-binding (PTB) protein functions in most or all cell types to regulate a wide spectrum of transcripts, Drosophila PTB encodes an abundant male germline-specific mRNA isoform (dmPTB) whose expression correlates w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ce837533e3e9bd12330dc76168848c
https://doi.org/10.1073/pnas.1007935107
https://doi.org/10.1073/pnas.1007935107
Publikováno v:
Nucleic Acids Research
The Est3 subunit of yeast telomerase, which adopts a predicted OB-fold, is essential for telomere replication. To assess the possible contributions that Est3 might make to enzyme catalysis, we compared telomerase activity from wild type and est3-Delt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdb1dc5e14dd415a44bc9959d2e21728
https://doi.org/10.1093/nar/gkp1173
https://doi.org/10.1093/nar/gkp1173
Autor:
William A. Gaines, Timsi Rao, Kara A. Bernstein, Stephen K. Godin, Patrick Sung, Andrew P. VanDemark, Faiz F. Kabbinavar
Publikováno v:
Nature Communications
The conserved budding yeast Rad51 paralogues, including Rad55, Rad57, Csm2 and Psy3 are indispensable for homologous recombination (HR)-mediated chromosome damage repair. Rad55 and Rad57 are associated in a heterodimer, while Csm2 and Psy3 form the S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6c24c4cad00011cb20de4aaa77980cf
https://pubmed.ncbi.nlm.nih.gov/26215801
https://pubmed.ncbi.nlm.nih.gov/26215801
Autor:
Timsi Rao, Timothy M. Tucey, Geoffrey S. Armstrong, Victoria Lundblad, Johnathan W. Lubin, Deborah S. Wuttke
Telomerase is essential for continuous cellular proliferation. Substantial insights have come from studies of budding yeast telomerase, which consists of a catalytic core in association with two regulatory proteins, ever shorter telomeres 1 and 3 (Es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41e5d49c4b75e470e91546bcc13d32b3
https://europepmc.org/articles/PMC3890887/
https://europepmc.org/articles/PMC3890887/
