Výsledky vyhledávání - "Timothy Z Vitalis"

Akademický článek

A unique carrier for delivery of therapeutic compounds beyond the blood-brain barrier.

Autor: Delara Karkan, Cheryl Pfeifer, Timothy Z Vitalis, Gavin Arthur, Maki Ujiie, Qingqi Chen, Sam Tsai, Gerrasimo Koliatis, Reinhard Gabathuler, Wilfred A Jefferies

Publikováno v: PLoS ONE, Vol 3, Iss 6, p e2469 (2008)

BACKGROUND: Therapeutic intervention in many neurological diseases is thwarted by the physical obstacle formed by the blood-brain barrier (BBB) that excludes most drugs from entering the brain from the blood. Thus, identifying efficacious modes of dr

Externí odkaz: https://doaj.org/article/97976960b78b4a45b2e503e66f593fb3

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Akademický článek

Using the TAP component of the antigen-processing machinery as a molecular adjuvant.

Autor: Timothy Z Vitalis, Qian-Jin Zhang, Judie Alimonti, Susan S Chen, Genc Basha, Alex Moise, Jacqueline Tiong, Mei Mei Tian, Kyung Bok Choi, Douglas Waterfield, Andy Jeffries, Wilfred A Jefferies

Publikováno v: PLoS Pathogens, Vol 1, Iss 4, p e36 (2005)

We hypothesize that over-expression of transporters associated with antigen processing (TAP1 and TAP2), components of the major histocompatibility complex (MHC) class I antigen-processing pathway, enhances antigen-specific cytotoxic activity in respo

Externí odkaz: https://doaj.org/article/a3faf129b9b9437ea34fcbba6e98e1fc

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Akademický článek

Discovery of a Highly Conserved Peptide in the Iron Transporter Melanotransferrin that Traverses an Intact Blood Brain Barrier and Localizes in Neural Cells

Autor: Chaahat S. B. Singh, Brett A. Eyford, Thomas Abraham, Lonna Munro, Kyung Bok Choi, Mark Okon, Timothy Z. Vitalis, Reinhard Gabathuler, Chieh-Ju Lu, Cheryl G. Pfeifer, Mei Mei Tian, Wilfred A. Jefferies

Publikováno v: Frontiers in Neuroscience, Vol 15 (2021)

The blood-brain barrier (BBB) hinders the distribution of therapeutics intended for treatment of diseases of the brain. Our previous studies demonstrated that that a soluble form of melanotransferrin (MTf; Uniprot P08582; also known as p97, MFI2, and

Externí odkaz: https://doaj.org/article/288f8666a28c48d19137c9e3c081e799

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Akademický článek

A Nanomule Peptide Carrier Delivers siRNA Across the Intact Blood-Brain Barrier to Attenuate Ischemic Stroke

Autor: Brett A. Eyford, Chaahat S. B. Singh, Thomas Abraham, Lonna Munro, Kyung Bok Choi, Tracy Hill, Rhonda Hildebrandt, Ian Welch, Timothy Z. Vitalis, Reinhard Gabathuler, Jacob A. Gordon, Hans Adomat, Emma S.T. Guns, Chieh-Ju Lu, Cheryl G. Pfeifer, Mei Mei Tian, Wilfred A. Jefferies

Publikováno v: Frontiers in Molecular Biosciences, Vol 8 (2021)

The blood-brain barrier (BBB) hinders the distribution of therapeutics intended for treatment of neuroinflammation (NI) of the central nervous system. A twelve-amino acid peptide that transcytoses the BBB, termed MTfp, was chemically conjugated to si

Externí odkaz: https://doaj.org/article/a03a0a8be37540beb76b28f2d46208c8

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A Nanomule Peptide Carrier Delivers siRNA Across the Intact Blood-Brain Barrier to Attenuate Ischemic Stroke

Publikováno v: Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 8 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c93c0bef904be18160623788d2e1fc91
https://pubmed.ncbi.nlm.nih.gov/34026851

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Discovery of a Highly Conserved Peptide in the Iron Transporter Melanotransferrin that Traverses an Intact Blood Brain Barrier and Localizes in Neural Cells

Publikováno v: Frontiers in Neuroscience
Frontiers in Neuroscience, Vol 15 (2021)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e6f31ca76d5d9450525ebec71b42e50
https://pubmed.ncbi.nlm.nih.gov/34149342

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A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model

Autor: Wilfred A. Jefferies, George Thom, Carl I. Webster, Thomas Abraham, Reinhard Gabathuler, Ian Gurrell, Mei Mei Tian, Timothy Z. Vitalis, Natalia Rodrigo, Jon P. Hatcher, Matthew Burrell

Publikováno v: J Cereb Blood Flow Metab

Delivery of biologic drugs across the blood–brain barrier is becoming a reality. However, the solutions often involve the assembly of complex multi-specific antibody molecules. Here we utilize a simple 12 amino-acid peptide originating from the mel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c563beb683756187a29f52b5efff7de8
https://pubmed.ncbi.nlm.nih.gov/29845881

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Basal medium composition and serum or serum replacement concentration influences on the maintenance of murine embryonic stem cells

Autor: James M. Piret, Timothy Z. Vitalis, Muhammad A. Chaudhry, Bruce D. Bowen

Publikováno v: Cytotechnology. 58:173-179

The expansion of stem cell numbers while retaining their developmental properties is a bioprocess challenge. We compared the growth rates and embryoid body (EB) formation yields of R1 and EFC murine embryonic stem cells (mESC) cultured in two basal m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9f1d9d855ca2684536945c5ed9f3cf
https://doi.org/10.1007/s10616-008-9177-5

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