Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Timothy Y. Huang"'
Autor:
Michael L. van de Weijer, Krishna Samanta, Nikita Sergejevs, LuLin Jiang, Maria Emilia Dueñas, Tiaan Heunis, Timothy Y. Huang, Randal J. Kaufman, Matthias Trost, Sumana Sanyal, Sally A. Cowley, Pedro Carvalho
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Immune surveillance by cytotoxic T cells eliminates tumor cells and cells infected by intracellular pathogens. This process relies on the presentation of antigenic peptides by Major Histocompatibility Complex class I (MHC-I) at the cell surf
Externí odkaz:
https://doaj.org/article/48a91d8bd1874f4caa6ab396c81c07b0
Autor:
Bing Zhu, Yan Liu, Spring Hwang, Kailey Archuleta, Huijie Huang, Alex Campos, Rabi Murad, Juan Piña-Crespo, Huaxi Xu, Timothy Y. Huang
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-24 (2022)
Abstract Background Alzheimer’s disease (AD) is a neurodegenerative disorder that manifests sequential Aβ and tau brain pathology with age-dependent onset. Variants in the microglial immune receptor TREM2 are associated with enhanced risk of onset
Externí odkaz:
https://doaj.org/article/0541d50ee2fb468380405e80ced1fc80
Autor:
Peng Zhao, Yuanzhong Xu, Lu-Lin Jiang, Xuejun Fan, Zhiqiang Ku, Leike Li, Xiaoye Liu, Mi Deng, Hisashi Arase, Jay-Jiguang Zhu, Timothy Y. Huang, Yingjun Zhao, Chengcheng Zhang, Huaxi Xu, Qingchun Tong, Ningyan Zhang, Zhiqiang An
Publikováno v:
Molecular Neurodegeneration, Vol 17, Iss 1, Pp 1-28 (2022)
Abstract Background Microglia plays crucial roles in Alzheimer’s disease (AD) development. Triggering receptor expressed on myeloid cells 2 (TREM2) in association with DAP12 mediates signaling affecting microglia function. Here we study the negativ
Externí odkaz:
https://doaj.org/article/375488437204489ba10baa9354be3594
Autor:
Qiuyang Zheng, Beibei Song, Guilin Li, Fang Cai, Meiling Wu, Yingjun Zhao, LuLin Jiang, Tiantian Guo, Mingyu Shen, Huan Hou, Ying Zhou, Yini Zhao, Anjie Di, Lishan Zhang, Fanwei Zeng, Xiu-Fang Zhang, Hong Luo, Xian Zhang, Hongfeng Zhang, Zhiping Zeng, Timothy Y. Huang, Chen Dong, Hong Qing, Yun Zhang, Qing Zhang, Xu Wang, Yili Wu, Huaxi Xu, Weihong Song, Xin Wang
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)
Down syndrome (DS), or trisomy 21, is one of the critical risk factors for early-onset Alzheimer’s disease (AD), implicating key roles for chromosome 21–encoded genes in the pathogenesis of AD. We previously identified a role for the deubiquitina
Externí odkaz:
https://doaj.org/article/31b1783f35ed41c69b3c8b868c85a09c
Publikováno v:
Molecular Neurodegeneration, Vol 15, Iss 1, Pp 1-37 (2020)
Abstract Alzheimer’s disease (AD) is the most common neurodegenerative disorder seen in age-dependent dementia. There is currently no effective treatment for AD, which may be attributed in part to lack of a clear underlying mechanism. Studies withi
Externí odkaz:
https://doaj.org/article/87e45de2e1e341bf934e767a8fa17cad
Publikováno v:
Translational Neurodegeneration, Vol 7, Iss 1, Pp 1-16 (2018)
Abstract Background Alzheimer’s disease (AD) is a fatal disease that threatens the quality of life of an aging population at a global scale. Various hypotheses on the etiology of AD have been developed over the years to guide efforts in search of t
Externí odkaz:
https://doaj.org/article/ceaa63c97f7147c7abf3dbfdff99f71a
Autor:
Kai Zhuang, Changquan Huang, Lige Leng, Honghua Zheng, Yuehong Gao, Guimiao Chen, Zhilin Ji, Hao Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Guojun Bu, Timothy Y. Huang, Huaxi Xu, Jie Zhang
Publikováno v:
Cell Reports, Vol 24, Iss 3, Pp 701-712 (2018)
Summary: Menin (MEN1) is a critical modulator of tissue development and maintenance. As such, MEN1 mutations are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. Although menin is abundantly expressed in the nervous system, little
Externí odkaz:
https://doaj.org/article/bd9432cb7fdd48ec980406a951818154
Autor:
Yongzhuang Xie, Mengxi Niu, Chengxiang Ji, Timothy Y. Huang, Cuilin Zhang, Ye Tian, Zhun Shi, Chen Wang, Yingjun Zhao, Hong Luo, Dan Can, Huaxi Xu, Yun-wu Zhang, Xian Zhang
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2019)
Dysregulation of various APP trafficking components in the endosome has been previously implicated in Alzheimer’s disease (AD). Although single nucleotide polymorphisms within the gene locus encoding the endosomal component, SNX8 have been previous
Externí odkaz:
https://doaj.org/article/1608993465ff4464a1ceeb473faa07ea
Autor:
Cuilin Zhang, Zhenqiu Tan, Yongzhuang Xie, Yingjun Zhao, Timothy Y. Huang, Zhaoping Lu, Hong Luo, Dan Can, Huaxi Xu, Yun-wu Zhang, Xian Zhang
Publikováno v:
Frontiers in Aging Neuroscience, Vol 11 (2019)
Oxidative stress is a common feature of neurodegenerative diseases and plays an important role in disease progression. Appoptosin is a pro-apoptotic protein that contributes to the pathogenesis of neurodegenerative diseases such as Alzheimer's diseas
Externí odkaz:
https://doaj.org/article/3a337de71f4e4a709127fe6c340e47e9
Autor:
Yue Gao, Yujuan Hong, Lihong Huang, Shuang Zheng, Haibin Zhang, Shihua Wang, Yi Yao, Yini Zhao, Lin Zhu, Qiang Xu, Xuhui Chai, Yuanyuan Zeng, Yuzhe Zeng, Liangkai Zheng, Yulin Zhou, Hong Luo, Xian Zhang, Hongfeng Zhang, Ying Zhou, Guo Fu, Hao Sun, Timothy Y. Huang, Qiuyang Zheng, Huaxi Xu, Xin Wang
Publikováno v:
Cell. 186:1026-1038.e20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73764744100c27cbc2bc08ce9f7d8408
https://doi.org/10.1016/j.cell.2023.01.021
https://doi.org/10.1016/j.cell.2023.01.021