Zobrazeno 1 - 10
of 198
pro vyhledávání: '"Timothy W. Synold"'
Autor:
Xiaoqiang Wang, Yin S. Chan, Kelly Wong, Ryohei Yoshitake, David Sadava, Timothy W. Synold, Paul Frankel, Przemyslaw W. Twardowski, Clayton Lau, Shiuan Chen
Publikováno v:
Cancers, Vol 15, Iss 3, p 701 (2023)
Cancer progression and mortality remain challenging because of current obstacles and limitations in cancer treatment. Continuous efforts are being made to explore complementary and alternative approaches to alleviate the suffering of cancer patients.
Externí odkaz:
https://doaj.org/article/058768b4ff3845b3aa1cce8c167f5d69
Autor:
Margarita Gutova, Leanne Goldstein, Marianne Metz, Anahit Hovsepyan, Lyudmila G. Tsurkan, Revathiswari Tirughana, Lusine Tsaturyan, Alexander J. Annala, Timothy W. Synold, Zesheng Wan, Robert Seeger, Clarke Anderson, Rex A. Moats, Philip M. Potter, Karen S. Aboody
Publikováno v:
Molecular Therapy: Oncolytics, Vol 4, Iss C, Pp 67-76 (2017)
Despite improved survival for children with newly diagnosed neuroblastoma (NB), recurrent disease is a significant problem, with treatment options limited by anti-tumor efficacy, patient drug tolerance, and cumulative toxicity. We previously demonstr
Externí odkaz:
https://doaj.org/article/5c7db55070fa4313a9cda696861dc9fa
Autor:
Margarita Gutova, Linda Flores, Vikram Adhikarla, Lusine Tsaturyan, Revathiswari Tirughana, Soraya Aramburo, Marianne Metz, Joanna Gonzaga, Alexander Annala, Timothy W. Synold, Jana Portnow, Russell C. Rockne, Karen S. Aboody
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
Neural stem cells (NSCs) are inherently tumor-tropic, which allows them to migrate through normal tissue and selectively localize to invasive tumor sites in the brain. We have engineered a clonal, immortalized allogeneic NSC line (HB1.F3.CD21; CD-NSC
Externí odkaz:
https://doaj.org/article/e2940e7905ce47aeacc9f5e793103521
Autor:
Mustafa Raoof, Kevin M. Sullivan, Paul H. Frankel, Marwan Fakih, Timothy W. Synold, Dean Lim, Yanghee Woo, Isaac Benjamin Paz, Yuman Fong, Rebecca Meera Thomas, Sue Chang, Melissa Eng, Raechelle Tinsley, Richard L. Whelan, Danielle Deperalta, Marc A. Reymond, Jeremy Jones, Amit Merchea, Thanh H. Dellinger
Publikováno v:
Pleura and Peritoneum. 7:169-177
Objectives Peritoneal metastasis (PM) from appendiceal cancer or colorectal cancer (CRC) has significant morbidity and limited survival. Pressurized intraperitoneal aerosolized chemotherapy (PIPAC) is a minimally invasive approach to treat PM. We aim
Autor:
Edward M. Newman, Steven T. Rosen, Larry W. Kwak, Stephen J. Forman, Wing C. Chan, Xiwei Wu, Shu Tao, Joo Y. Song, Shuhua Yi, Leslie Popplewell, Matthew Mei, Sandrine Puverel, Vu N. Ngo, Timothy W. Synold, Yuming Guo, Jun Wu, Lu Chen, Jessie Hou, Alex F. Herrera, Robert Chen
Purpose:In classical Hodgkin lymphoma, the malignant Reed–Sternberg cells express the cell surface marker CD30. Brentuximab vedotin is an antibody–drug conjugate (ADC) that selectively delivers a potent cytotoxic agent, monomethyl auristatin E (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1f99f4335206caf0e0bfe40ead27fe
https://doi.org/10.1158/1078-0432.c.6528321
https://doi.org/10.1158/1078-0432.c.6528321
Autor:
Karen S. Aboody, Mike Chen, Paul Frankel, Margarita Gutova, Tien Vo, Victoria Bedell, Joseph Najbauer, Marianne Z. Metz, Massimo D'Apuzzo, Simon F. Lacey, Revathiswari Tirughana, Behnam Badie, Timothy W. Synold, Jana Portnow
Purpose: Human neural stem cells (NSC) are inherently tumor tropic, making them attractive drug delivery vehicles. Toward this goal, we retrovirally transduced an immortalized, clonal NSC line to stably express cytosine deaminase (HB1.F3.CD.C21; CD-N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ab89cbd3f2f7dadf975717cb752040
https://doi.org/10.1158/1078-0432.c.6525081
https://doi.org/10.1158/1078-0432.c.6525081
Autor:
Edward M. Newman, S. Percy Ivy, S. Cecilia Lau, Leena Gandhi, Chandra P. Belani, Daniel L. Mulkerin, Afshin Dowlati, Michelle A. Rudek, Patricia LoRusso, John Sarantopoulos, Bert H. O'Neil, Anne L. Hamilton, R. Donald Harvey, Shivaani Kummar, Heinz-Josef Lenz, Lone H. Ottesen, A. Benjamin Suttle, Jeffrey A. Longmate, Timothy W. Synold, Vincent Chung, Stephen I. Shibata
PDF - 90K, Supplemental Table 1: Most Frequently Reported Adverse Events at Least Possibly Related to Pazopanib Supplemental Table 2: Steady-State Pazopanib Metabolite Pharmacokinetics Measured in All Patients at Week 3 (medians and ranges) Supplemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d15641f7e868af03b66588542f389d
https://doi.org/10.1158/1078-0432.22452693.v1
https://doi.org/10.1158/1078-0432.22452693.v1
Autor:
Linda H. Malkas, David Horne, Karen L. Reckamp, Yanhong Shi, Timothy W. Synold, Steven L. Vonderfecht, Yuan Chen, Yate-Ching Yuan, Jeremy M. Stark, Robert J. Hickey, Hongzhi Li, Weidong Hu, Jianfei Chao, Qi Cui, Emily Sun, Fumiko Yakushijin, Robert Lingeman, Long Gu
Purpose:Proliferating cell nuclear antigen (PCNA) plays an essential role in regulating DNA synthesis and repair and is indispensable to cancer cell growth and survival. We previously reported a novel cancer associated PCNA isoform (dubbed caPCNA), w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77302088a500d8ef947ebbbb547ea4f3
https://doi.org/10.1158/1078-0432.c.6527253.v1
https://doi.org/10.1158/1078-0432.c.6527253.v1
Autor:
Edward M. Newman, S. Percy Ivy, S. Cecilia Lau, Leena Gandhi, Chandra P. Belani, Daniel L. Mulkerin, Afshin Dowlati, Michelle A. Rudek, Patricia LoRusso, John Sarantopoulos, Bert H. O'Neil, Anne L. Hamilton, R. Donald Harvey, Shivaani Kummar, Heinz-Josef Lenz, Lone H. Ottesen, A. Benjamin Suttle, Jeffrey A. Longmate, Timothy W. Synold, Vincent Chung, Stephen I. Shibata
Purpose: Pazopanib is a potent, multitargeted receptor tyrosine kinase inhibitor; however, there is limited information regarding the effects of liver function on pazopanib metabolism and pharmacokinetics. The objective of this study was to establish
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d59996474bd83689123ac9fd61ea25
https://doi.org/10.1158/1078-0432.c.6522558
https://doi.org/10.1158/1078-0432.c.6522558
Autor:
Edward M. Newman, Steven T. Rosen, Larry W. Kwak, Stephen J. Forman, Wing C. Chan, Xiwei Wu, Shu Tao, Joo Y. Song, Shuhua Yi, Leslie Popplewell, Matthew Mei, Sandrine Puverel, Vu N. Ngo, Timothy W. Synold, Yuming Guo, Jun Wu, Lu Chen, Jessie Hou, Alex F. Herrera, Robert Chen
Supplementary Figure 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cfccd0e0186aff25e8b2235b165dd8f
https://doi.org/10.1158/1078-0432.22472784.v1
https://doi.org/10.1158/1078-0432.22472784.v1