Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Timothy W. Rhoads"'
Autor:
Christian J. Elliehausen, Rozalyn M. Anderson, Gary M. Diffee, Timothy W. Rhoads, Dudley W. Lamming, Troy A. Hornberger, Adam R. Konopka
Publikováno v:
BMC Biology, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Physical activity and several pharmacological approaches individually combat age-associated conditions and extend healthy longevity in model systems. It is tantalizing to extrapolate that combining geroprotector drugs with exercise could ext
Externí odkaz:
https://doaj.org/article/ce8d8741c2d444e894d37204ef2479d7
Autor:
Alex B. Smith, Jonah P. Schill, Ruth Gordillo, Grace E. Gustafson, Timothy W. Rhoads, Maggie S. Burhans, Aimee T. Broman, Ricki J. Colman, Philipp E. Scherer, Rozalyn M. Anderson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Metabolic syndrome increases risk of complicating co-morbidities. Current clinical indicators reflect established metabolic impairment, preventing earlier intervention strategies. Here we show that circulating sphingolipids are altered in th
Externí odkaz:
https://doaj.org/article/43f3986a7da74abcbd070096cce668a7
Autor:
Inca A. Dieterich, Alexis J. Lawton, Yajing Peng, Qing Yu, Timothy W. Rhoads, Katherine A. Overmyer, Yusi Cui, Eric A. Armstrong, Porsha R. Howell, Maggie S. Burhans, Lingjun Li, John M. Denu, Joshua J. Coon, Rozalyn M. Anderson, Luigi Puglielli
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The Endoplasmic Reticulum acetylation machinery ensures proper quality control and disposal of newly folded proteins transiting the secretory pathway. Here, the authors show that this machinery acts as a metabolic regulator of acetyl-CoA homeostasis,
Externí odkaz:
https://doaj.org/article/0d4577b03c594bb194303bbedd2c9a54
Autor:
Joshua M. Baughman, Christopher M. Rose, Ganesh Kolumam, Joshua D. Webster, Emily M. Wilkerson, Anna E. Merrill, Timothy W. Rhoads, Rajkumar Noubade, Paula Katavolos, Justin Lesch, Donald S. Stapleton, Mary E. Rabaglia, Kathy L. Schueler, Raymond Asuncion, Melanie Domeyer, Jose Zavala-Solorio, Michael Reich, Jason DeVoss, Mark P. Keller, Alan D. Attie, Alexander S. Hebert, Michael S. Westphall, Joshua J. Coon, Donald S. Kirkpatrick, Anwesha Dey
Publikováno v:
Cell Reports, Vol 16, Iss 2, Pp 583-595 (2016)
We introduce neutron-encoded (NeuCode) amino acid labeling of mice as a strategy for multiplexed proteomic analysis in vivo. Using NeuCode, we characterize an inducible knockout mouse model of Bap1, a tumor suppressor and deubiquitinase whose in vivo
Externí odkaz:
https://doaj.org/article/8cdbcd1118fe43d0a32e0e75203ce3e3
Autor:
Jared R. Williams, Emiliano Trias, Pamela R. Beilby, Nathan I. Lopez, Edwin M. Labut, C. Samuel Bradford, Blaine R. Roberts, Erin J. McAllum, Peter J. Crouch, Timothy W. Rhoads, Cliff Pereira, Marjatta Son, Jeffrey L. Elliott, Maria Clara Franco, Alvaro G. Estévez, Luis Barbeito, Joseph S. Beckman
Publikováno v:
Neurobiology of Disease, Vol 89, Iss , Pp 1-9 (2016)
Over-expression of mutant copper, zinc superoxide dismutase (SOD) in mice induces ALS and has become the most widely used model of neurodegeneration. However, no pharmaceutical agent in 20 years has extended lifespan by more than a few weeks. The Cop
Externí odkaz:
https://doaj.org/article/317f96cedfe543dcbf44df3fa341418c
Autor:
Christopher S. Morrow, Darcie L. Moore, Chung-Yang Yeh, Korbyn Dahlquist, Matthew J. Yousefzadeh, John M. Denu, Michaela E Murphy, Chathurika Henpita, Tadataka Tsuji, Reji Babygirija, Josef P. Clark, Yagna P. R. Jarajapu, Timothy W. Rhoads, Alexis Adrian, Heidi H. Pak, Claire E Richardson, Mariah Calubag, Cara L Green, Cristal M. Hill, Rong Yuan, Ankur Kumar, Michelle Sonsalla, Kishore Chittimalli, Christina D. Camell, Vinal Menon, Mark Bouska, Heather A. Simmons, Yun Zhu, Kyoo-A Lee, Dudley W. Lamming, Eric R McGregor, Hua Bai, Judith Simcox, Carolina Soto-Palma, Akilavalli Narasimhan
Publikováno v:
GeroScience
Autor:
Alex Smith, Jonah P. Schill, Ruth Gordillo, Grace E. Gustafson, Timothy W. Rhoads, Maggie S. Burhans, Aimee T. Broman, Ricki J. Colman, Philipp E. Scherer, Rozalyn M. Anderson
Metabolic syndrome increases risk of complicating co-morbidities. Current clinical indicators reflect established metabolic impairment, preventing earlier intervention strategies. Here we show that circulating sphingolipids are altered in the very ea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0888a811d46ffb419cbc22cee6c47477
https://doi.org/10.21203/rs.3.rs-1069222/v1
https://doi.org/10.21203/rs.3.rs-1069222/v1
Autor:
Timothy W. Rhoads, Rozalyn M. Anderson
Publikováno v:
Science. 375:620-621
Reverse translation of a human caloric restriction trial finds an immunometabolic regulator
Autor:
Aaron A. Hoskins, Timothy W. Rhoads
Publikováno v:
Mol Cell
Oxidative phosphorylation (OXPHOS) and glycolysis are the two major pathways for ATP production. The reliance on each varies across tissues and cell states, and can influence susceptibility to disease. At present, the full set of molecular mechanisms
Autor:
Timothy W. Rhoads, Rozalyn M. Anderson
Publikováno v:
Cell Metabolism. 32:323-325
In this issue of Cell Metabolism, Asadi Shahmirzadi et al. (2020) demonstrate that late-onset dietary supplementation with calcium alpha-ketoglutarate results in increased survival, compressed morbidity, and reduced frailty in mice. The study provide