Zobrazeno 1 - 10
of 89
pro vyhledávání: '"Timothy W. Bredy"'
Autor:
Wei-Siang Liau, Qiongyi Zhao, Adekunle Bademosi, Rachel S. Gormal, Hao Gong, Paul R. Marshall, Ambika Periyakaruppiah, Sachithrani U. Madugalle, Esmi L. Zajaczkowski, Laura J. Leighton, Haobin Ren, Mason Musgrove, Joshua Davies, Simone Rauch, Chuan He, Bryan C. Dickinson, Xiang Li, Wei Wei, Frédéric A. Meunier, Sandra M. Fernández-Moya, Michael A. Kiebler, Balakumar Srinivasan, Sourav Banerjee, Michael Clark, Robert C. Spitale, Timothy W. Bredy
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Long noncoding RNAs (lncRNAs) represent a multidimensional class of regulatory molecules that are involved in many aspects of brain function. Emerging evidence indicates that lncRNAs are localized to the synapse; however, a direct role for t
Externí odkaz:
https://doaj.org/article/988e064ab265447988a0b34da83e4592
Autor:
Wei Wei, Qiongyi Zhao, Ziqi Wang, Wei-Siang Liau, Dean Basic, Haobin Ren, Paul R. Marshall, Esmi L. Zajaczkowski, Laura J. Leighton, Sachithrani U. Madugalle, Mason Musgrove, Ambika Periyakaruppiah, Jichun Shi, Jianjian Zhang, John S. Mattick, Timothy R. Mercer, Robert C. Spitale, Xiang Li, Timothy W. Bredy
Publikováno v:
Cell Reports, Vol 38, Iss 12, Pp 110546- (2022)
Summary: Here, we used RNA capture-seq to identify a large population of lncRNAs that are expressed in the infralimbic prefrontal cortex of adult male mice in response to fear-related learning. Combining these data with cell-type-specific ATAC-seq on
Externí odkaz:
https://doaj.org/article/780e722429aa497c8ef62de662ee166e
Autor:
Monica D. Bjørge, Gunn A. Hildrestrand, Katja Scheffler, Rajikala Suganthan, Veslemøy Rolseth, Anna Kuśnierczyk, Alexander D. Rowe, Cathrine B. Vågbø, Susanne Vetlesen, Lars Eide, Geir Slupphaug, Yusaku Nakabeppu, Timothy W. Bredy, Arne Klungland, Magnar Bjørås
Publikováno v:
Cell Reports, Vol 13, Iss 12, Pp 2671-2678 (2015)
Ogg1 and Mutyh DNA glycosylases cooperate to prevent mutations caused by 8-oxoG, a major premutagenic DNA lesion associated with cognitive decline. We have examined behavior and cognitive function in mice deficient of these glycosylases. Ogg1−/−M
Externí odkaz:
https://doaj.org/article/4ac21c419fc4404d848fbcaac9fd6541
Autor:
Laura J. Leighton, Timothy W. Bredy
Publikováno v:
Non-Coding RNA, Vol 4, Iss 2, p 15 (2018)
Small non-coding RNAs are essential for transcription, translation and gene regulation in all cell types, but are particularly important in neurons, with known roles in neurodevelopment, neuroplasticity and neurological disease. Many small non-coding
Externí odkaz:
https://doaj.org/article/6277c6300092476092a75ad3c40563e6
Autor:
Paul R. Marshall, Qiongyi Zhao, Joshua Davies, Wei-Siang Liau, Yujin Lee, Dean Basic, Ambika Periyakaruppiah, Esmi L. Zajaczkowski, Laura J. Leighton, Sachithrani U. Madugalle, Mason Musgrove, Marcin Kielar, Hao Gong, Haobin Ren, Lech Kaczmarczyk, Walker S. Jackson, Alon Chen, Robert C. Spitale, Timothy W. Bredy
The conformational state of DNA fine-tunes the transcriptional rate and abundance of RNA. Here we report that DNA G-quadruplex (G4-DNA) accumulates in neurons in an experience-dependent manner, and that this is required for the transient silencing an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c92f219ce356988d031421b1512a44d4
https://doi.org/10.1101/2023.01.09.523337
https://doi.org/10.1101/2023.01.09.523337
Autor:
Sachithrani U. Madugalle, Wei-Siang Liau, Qiongyi Zhao, Xiang Li, Hao Gong, Paul R. Marshall, Ambika Periyakaruppiah, Esmi L. Zajackowski, Laura J. Leighton, Haobin Ren, Mason Musgrove, Joshua Davies, Simone Rauch, Chuan He, Bryan C. Dickinson, Lee Fletcher, Barbora Fulopova, Stephen R. Williams, Robert C. Spitale, Timothy W. Bredy
SummaryThe RNA modification N6-methyladenosine (m6A) is critically involved in the regulation of gene activity underlying experience-dependent plasticity, and is necessary for the functional interplay between RNA and RNA binding proteins (RBPs) in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da48fb87699dfd061793e8594f370990
https://doi.org/10.1101/2022.06.07.495230
https://doi.org/10.1101/2022.06.07.495230
Publikováno v:
Trends in Neurosciences. 43:1011-1023
A major challenge in neurobiology in the 21st century is to understand how the brain adapts with experience. Activity-dependent gene expression is integral to the synaptic plasticity underlying learning and memory; however, this process cannot be exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e064506a3f68defbfdccc053d40cabc
https://doi.org/10.1016/j.tins.2020.09.005
https://doi.org/10.1016/j.tins.2020.09.005
Autor:
Laura J. Leighton, Qiongyi Zhao, Paul R. Marshall, Sachithrani U. Madugalle, Angelo H. C. Chan, Mason R. B. Musgrove, Haobin Ren, Ambika Periyakaruppiah, Janette Edson, Wei Wei, Xiang Li, Robert C. Spitale, Timothy W. Bredy
C/D box small nucleolar RNAs (snoRNAs) comprise a class of small noncoding RNAs with important regulatory effects on cellular RNA function. Although it is well established that snoRNAs coordinate the post-transcriptional modification of pre-ribosomal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57644c8d27df38b8f78ff2329039ffb6
https://doi.org/10.1101/2022.05.09.491263
https://doi.org/10.1101/2022.05.09.491263
Autor:
Wei-Siang Liau, Qiongyi Zhao, Adekunle Bademosi, Rachel Gormal, Hao Gong, Paul R. Marshall, Ambika Periyakaruppiah, Sachithrani U. Madugalle, Esmi L. Zajackowski, Laura J. Leighton, Haobin Ren, Mason Musgrove, Joshua Davies, Simone Rauch, Chuan He, Bryan C. Dickinson, Xiang Li, Wei Wei, Frédéric A. Meunier, Sandra M. Fernandez Moya, Michael A. Kiebler, Bharath Srinivasan, Sourav Banerjee, Michael Clark, Robert C. Spitale, Timothy W. Bredy
SummaryLong noncoding RNAs (lncRNAs) represent a multidimensional class of regulatory molecules involved in many aspects of brain function. Emerging evidence indicates that lncRNAs are expressed at the synapse; however, a direct role for their activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4eaf72765a02621455c60964b096ed74
https://doi.org/10.1101/2022.03.30.486308
https://doi.org/10.1101/2022.03.30.486308
Autor:
Esmi L. Zajaczkowski, Timothy W. Bredy
Publikováno v:
The Neuroscientist
Higher-order organisms possess information processing capabilities that are only made possible by their biological complexity. Emerging evidence indicates a critical role for regulatory RNAs in coordinating many aspects of cellular function that are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e84a677eaceb5dc4c6b646ccebd595
https://doi.org/10.1177/1073858420963028
https://doi.org/10.1177/1073858420963028