Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Timothy W Kraft"'
Autor:
Nicolas F Berbari, Erik B Malarkey, S M Zaki R Yazdi, Andrew D McNair, Jordyn M Kippe, Mandy J Croyle, Timothy W Kraft, Bradley K Yoder
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106576 (2014)
It has been known for decades that neurons throughout the brain possess solitary, immotile, microtubule based appendages called primary cilia. Only recently have studies tried to address the functions of these cilia and our current understanding rema
Externí odkaz:
https://doaj.org/article/2e71e71e05b6427483f04e4886628a6e
Autor:
Mai N. Nguyen, Dibyendu Chakraborty, Sriganesh Ramachandra Rao, Agnieszka Onysk, Mariusz Radkiewicz, Liliana Surmacz, Ewa Swiezewska, Eric Soubeyrand, Tariq A. Akhtar, Timothy W. Kraft, David M. Sherry, Steven J. Fliesler, Steven J. Pittler
Publikováno v:
Cell Death and Disease, Vol 14, Iss 7, Pp 1-10 (2023)
Abstract Retinitis pigmentosa (RP) defines a group of hereditary progressive rod-cone degenerations that exhibit a common phenotype caused by variants in over 70 genes. While most variants in the dehydrodolichyl diphosphate synthase (DHDDS) gene resu
Externí odkaz:
https://doaj.org/article/fee4e4b88da74e74bbf913af60ede5b9
Publikováno v:
Open Biology, Vol 8, Iss 8 (2018)
We examine the implications of a recent report providing evidence that two transducins must bind to the rod phosphodiesterase to elicit significant hydrolytic activity. To predict the rod photoreceptor's electrical response, we use numerical simulati
Externí odkaz:
https://doaj.org/article/af0c0bfb807e4763b52083e9da0db2fc
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 8; Pages: 4127
The full-field ERG is useful for index rod- or cone-mediated retinal function in rodent models of retinal degeneration. However, the relationship between the ERG response amplitudes and visually guided behavior, such as flicker detection, is not well
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc6283c5436b04ad2e71eff3f765f87
Autor:
Mustapha El Hamdaoui, Alexander M. Levy, Aaron B. Stuber, Christopher A. Girkin, Timothy W. Kraft, Brian C. Samuels, Rafael Grytz
Publikováno v:
Exp Eye Res
Scleral crosslinking using genipin has been identified as a promising treatment approach for myopia control. The efficacy of genipin to alter biomechanical properties of the sclera has been shown in several animal models of myopia but its safety prof
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a431de5573545e3f73ea1bec17ab15e
https://europepmc.org/articles/PMC9133212/
https://europepmc.org/articles/PMC9133212/
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 7; Pages: 3978
We investigated the etiology of decreased cone-driven vision in a light damage (LD) model of retinal degeneration. To induce slow, moderate degeneration, albino rats underwent low-intensity light exposure for 10 days. Electroretinography was utilized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2051a9852a4b9e203101ebf1c8dae7
https://pubmed.ncbi.nlm.nih.gov/35409336
https://pubmed.ncbi.nlm.nih.gov/35409336
Autor:
Timothy W. Kraft, Sriganesh Ramachandra Rao, Steven J. Fliesler, Steven J. Pittler, Stephanie J. Davis, Delores A. Stacks, Marci L DeRamus, Cyril Nii Amankwah Nyankerh
Publikováno v:
Cells
Volume 9
Issue 3
Cells, Vol 9, Iss 3, p 771 (2020)
Volume 9
Issue 3
Cells, Vol 9, Iss 3, p 771 (2020)
Patients with certain defects in the dehydrodolichyl diphosphate synthase (DHDDS) gene (RP59
OMIM #613861) exhibit classic symptoms of retinitis pigmentosa, as well as macular changes, suggestive of retinal pigment epithelium (RPE) involvement.
OMIM #613861) exhibit classic symptoms of retinitis pigmentosa, as well as macular changes, suggestive of retinal pigment epithelium (RPE) involvement.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d7391af164abc63e444ad84cb89052a
https://pubmed.ncbi.nlm.nih.gov/32245241
https://pubmed.ncbi.nlm.nih.gov/32245241
Autor:
Jennifer A. Davis, Karen L. Gamble, Jodi R. Paul, Rita M. Cowell, Alex S. McKeown, Stacie K. Totsch, Timothy W. Kraft, Eric M. Mintz
Publikováno v:
European Journal of Neuroscience. 45:1102-1110
Glycogen synthase kinase 3 (GSK3) is a serine-threonine kinase that regulates mammalian circadian rhythms at the behavioral, molecular and neurophysiological levels. In the central circadian pacemaker, the suprachiasmatic nucleus (SCN), inhibitory ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37adf7ed718e3a4f7e4b38d3fd205fc1
https://doi.org/10.1111/ejn.13549
https://doi.org/10.1111/ejn.13549
Publikováno v:
The Journal of Physiology. 594:1841-1854
Key points We propose that the end product of chromophore bleaching in rod photoreceptors, all-trans retinol, is part of a feedback loop that increases the sensitivity of the phototransduction cascade in rods. A previously described light-induced hyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56715421a3ecc8abdc1b18742f5ea0e8
https://doi.org/10.1113/jp271650
https://doi.org/10.1113/jp271650
Autor:
Timothy W. Kraft, Trevor D. Lamb
Publikováno v:
Open Biology
Open Biology, Vol 10, Iss 1 (2020)
Open Biology, Vol 10, Iss 1 (2020)
We develop an improved quantitative model of mammalian rod phototransduction, and we apply it to the prediction of responses to bright flashes of light. We take account of the recently characterized dimeric nature of PDE6 activation, where the config
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b3da614e4677554fc632412b2d5b11
https://doi.org/10.1098/rsob.190241
https://doi.org/10.1098/rsob.190241