Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Timothy W Gant"'
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93849 (2014)
Next generation sequencing technology has revolutionised microbiology by allowing concurrent analysis of whole microbial communities. Here we developed and verified similar methods for the analysis of fungal communities using a proton release sequenc
Externí odkaz:
https://doaj.org/article/2d03f83234d240f78278de35c65ad885
Autor:
Amy V Pointon, Tracy M Walker, Kate M Phillips, Jinli Luo, Joan Riley, Shu-Dong Zhang, Joel D Parry, Jonathan J Lyon, Emma L Marczylo, Timothy W Gant
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12733 (2010)
BackgroundDoxorubicin is one of the most effective anti-cancer drugs but its use is limited by cumulative cardiotoxicity that restricts lifetime dose. Redox damage is one of the most accepted mechanisms of toxicity, but not fully substantiated. Moreo
Externí odkaz:
https://doaj.org/article/184c284d03e04d15969cfbb2005712c1
Autor:
Nurshad Ali, Jenny Katsouli, Emma L. Marczylo, Timothy W. Gant, Stephanie Wright, Jorge Bernardino de la Serna
Publikováno v:
EBioMedicine, Vol 99, Iss , Pp 104901- (2024)
Summary: Humans are exposed to micro-and-nano plastics (MNPs) through various routes, but the adverse health effects of MNPs on different organ systems are not yet fully understood. This review aims to provide an overview of the potential impacts of
Externí odkaz:
https://doaj.org/article/692001eeac69417195a232ed38826c2b
Autor:
Kirsty Meldrum, Sarah B. Robertson, Isabella Römer, Tim Marczylo, Lareb S. N. Dean, Andrew Rogers, Timothy W. Gant, Rachel Smith, Terry D. Tetley, Martin O. Leonard
Publikováno v:
Particle and Fibre Toxicology, Vol 15, Iss 1, Pp 1-19 (2018)
Abstract Background Nanomaterial inhalation represents a potential hazard for respiratory conditions such as asthma. Cerium dioxide nanoparticles (CeO2NPs) have the ability to modify disease outcome but have not been investigated for their effect on
Externí odkaz:
https://doaj.org/article/3f9124a3d0664f8c801e320808f3a0ca
Autor:
Kirsty Meldrum, Chang Guo, Emma L. Marczylo, Timothy W. Gant, Rachel Smith, Martin O. Leonard
Publikováno v:
Particle and Fibre Toxicology, Vol 14, Iss 1, Pp 1-35 (2017)
Abstract Asthma is a chronic respiratory disease known for its high susceptibility to environmental exposure. Inadvertent inhalation of engineered or incidental nanomaterials is a concern for human health, particularly for those with underlying disea
Externí odkaz:
https://doaj.org/article/103a60df17e746b59c06c8c11ef2416e
Autor:
Piotr J. Kamola, Klio Maratou, Paul A. Wilson, Kay Rush, Tanya Mullaney, Tom McKevitt, Paula Evans, Jim Ridings, Probash Chowdhury, Aude Roulois, Ann Fairchild, Sean McCawley, Karen Cartwright, Nigel J. Gooderham, Timothy W. Gant, Kitty Moores, Stephen A. Hughes, Mark R. Edbrooke, Kenneth Clark, Joel D. Parry
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 8, Iss , Pp 383-394 (2017)
Antisense oligonucleotide (ASO) gapmers downregulate gene expression by inducing enzyme-dependent degradation of targeted RNA and represent a promising therapeutic platform for addressing previously undruggable genes. Unfortunately, their therapeutic
Externí odkaz:
https://doaj.org/article/b04a0634ef634c9784c5c5759a036d27
Autor:
Heather Jarman, Richard W Atkinson, Desislava Baramova, Timothy W Gant, Tim Marczylo, Isabella Myers, Shirley Price, Tom Quinn
Publikováno v:
Journal of Public Health.
Background Low-level exposure to carbon monoxide (CO) is a significant health concern but is difficult to diagnose. This main study aim was to establish the prevalence of low-level CO poisoning in Emergency Department (ED) patients. Methods A prospec
Autor:
Abdulkarim Najjar, Ans Punt, John Wambaugh, Alicia Paini, Corie Ellison, Styliani Fragki, Enrica Bianchi, Fagen Zhang, Joost Westerhout, Dennis Mueller, Hequn Li, Quan Shi, Timothy W. Gant, Phil Botham, Rémi Bars, Aldert Piersma, Ben van Ravenzwaay, Nynke I. Kramer
Publikováno v:
Archives of Toxicology 96 (2022) 12
Archives of Toxicology, 96(12), 3407-3419
Archives of Toxicology, 96(12), 3407-3419
With an increasing need to incorporate new approach methodologies (NAMs) in chemical risk assessment and the concomitant need to phase out animal testing, the interpretation of in vitro assay readouts for quantitative hazard characterisation becomes
Autor:
Shihori Tanabe, Jason O’Brien, Knut Erik Tollefsen, Youngjun Kim, Vinita Chauhan, Carole Yauk, Elizabeth Huliganga, Ruthann A. Rudel, Jennifer E. Kay, Jessica S. Helm, Danielle Beaton, Julija Filipovska, Iva Sovadinova, Natalia Garcia-Reyero, Angela Mally, Sarah Søs Poulsen, Nathalie Delrue, Ellen Fritsche, Karsta Luettich, Cinzia La Rocca, Hasmik Yepiskoposyan, Jördis Klose, Pernille Høgh Danielsen, Maranda Esterhuizen, Nicklas Raun Jacobsen, Ulla Vogel, Timothy W. Gant, Ian Choi, Rex FitzGerald
Publikováno v:
Frontiers in Toxicology. 4
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are formed as a result of natural cellular processes, intracellular signaling, or as adverse responses associated with diseases or exposure to oxidizing chemical and non-chemical stres
Publikováno v:
Ecohealth
Soil microbes are important for public health. Increasing urbanisation is adversely affecting soil microbiota, which may be contributing to the global rise of immune-related diseases. Fungi are key components of urban environments that can be negativ