Zobrazeno 1 - 10 of 143 pro vyhledávání: '"Timothy W Gant"'
1
Akademický článek
Structure confirmation, reactivity, bacterial mutagenicity and quantification of 2,2,4-tribromo-5-hydroxycyclopent-4-ene-1,3-dione in drinking water
Autor: Davide Ciccarelli, Ben M. J. Lancaster, D. Christopher Braddock, Matteo Calvaresi, Miroslav Mišík, Siegfried Knasmüller, Edoardo Jun Mattioli, Francesco Zerbetto, Andrew J. P. White, Tim Marczylo, Timothy W. Gant, Leon P. Barron
Publikováno v: Communications Chemistry, Vol 7, Iss 1, Pp 1-11 (2024)
Abstract The presence of two new disinfectant by-product (DBP) groups in the UK was recently shown using non-target analysis, halogenated-hydroxycyclopentenediones and halogenated-methanesulfonic acids. In this work, we confirmed the structure of 2,2
Externí odkaz: https://doaj.org/article/8e7906920ce74752a5e54c009d026104
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2
Akademický článek
Amplicon-based metagenomic analysis of mixed fungal samples using proton release amplicon sequencing.
Autor: Daniel P Tonge, Catherine H Pashley, Timothy W Gant
Publikováno v: PLoS ONE, Vol 9, Iss 4, p e93849 (2014)
Next generation sequencing technology has revolutionised microbiology by allowing concurrent analysis of whole microbial communities. Here we developed and verified similar methods for the analysis of fungal communities using a proton release sequenc
Externí odkaz: https://doaj.org/article/2d03f83234d240f78278de35c65ad885
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3
Akademický článek
Doxorubicin in vivo rapidly alters expression and translation of myocardial electron transport chain genes, leads to ATP loss and caspase 3 activation.
Autor: Amy V Pointon, Tracy M Walker, Kate M Phillips, Jinli Luo, Joan Riley, Shu-Dong Zhang, Joel D Parry, Jonathan J Lyon, Emma L Marczylo, Timothy W Gant
Publikováno v: PLoS ONE, Vol 5, Iss 9, p e12733 (2010)
BackgroundDoxorubicin is one of the most effective anti-cancer drugs but its use is limited by cumulative cardiotoxicity that restricts lifetime dose. Redox damage is one of the most accepted mechanisms of toxicity, but not fully substantiated. Moreo
Externí odkaz: https://doaj.org/article/184c284d03e04d15969cfbb2005712c1
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4
Akademický článek
The potential impacts of micro-and-nano plastics on various organ systems in humans
Autor: Nurshad Ali, Jenny Katsouli, Emma L. Marczylo, Timothy W. Gant, Stephanie Wright, Jorge Bernardino de la Serna
Publikováno v: EBioMedicine, Vol 99, Iss , Pp 104901- (2024)
Summary: Humans are exposed to micro-and-nano plastics (MNPs) through various routes, but the adverse health effects of MNPs on different organ systems are not yet fully understood. This review aims to provide an overview of the potential impacts of
Externí odkaz: https://doaj.org/article/692001eeac69417195a232ed38826c2b
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5
Towards best use and regulatory acceptance of generic physiologically based kinetic (PBK) models for in vitro-to-in vivo extrapolation (IVIVE) in chemical risk assessment
Autor: Abdulkarim Najjar, Ans Punt, John Wambaugh, Alicia Paini, Corie Ellison, Styliani Fragki, Enrica Bianchi, Fagen Zhang, Joost Westerhout, Dennis Mueller, Hequn Li, Quan Shi, Timothy W. Gant, Phil Botham, Rémi Bars, Aldert Piersma, Ben van Ravenzwaay, Nynke I. Kramer
Publikováno v: Archives of Toxicology 96 (2022) 12
Archives of Toxicology, 96(12), 3407-3419
With an increasing need to incorporate new approach methodologies (NAMs) in chemical risk assessment and the concomitant need to phase out animal testing, the interpretation of in vitro assay readouts for quantitative hazard characterisation becomes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bfbe3d0dd3f2deef7c7b999e3c70d53
https://doi.org/10.1007/s00204-022-03356-5
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6
Screening patients for unintentional carbon monoxide exposure in the Emergency Department: a cross-sectional multi-centre study
Autor: Heather Jarman, Richard W Atkinson, Desislava Baramova, Timothy W Gant, Tim Marczylo, Isabella Myers, Shirley Price, Tom Quinn
Publikováno v: Journal of Public Health.
Background Low-level exposure to carbon monoxide (CO) is a significant health concern but is difficult to diagnose. This main study aim was to establish the prevalence of low-level CO poisoning in Emergency Department (ED) patients. Methods A prospec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d524944bf1cd709a5a46b579aa7eb05
https://doi.org/10.1093/pubmed/fdad007
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9
Grouping of UVCB substances with dose-response transcriptomics data from human cell-based assays
Autor: John S, House, Fabian A, Grimm, William D, Klaren, Abigail, Dalzell, Srikeerthana, Kuchi, Shu-Dong, Zhang, Klaus, Lenz, Peter J, Boogaard, Hans B, Ketelslegers, Timothy W, Gant, Ivan, Rusyn, Fred A, Wright
Publikováno v: ALTEX.
The application of in vitro biological assays as new approach methodologies (NAMs) to support grouping of UVCB (unknown or variable composition, complex reaction products, and biological materials) substances has recently been demonstrated. In additi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::796ac6f76012776d139cd2018802b1fd
https://doi.org/10.14573/altex.2107051
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10
R-ODAF: Omics data analysis framework for regulatory application
Autor: Marcha CT. Verheijen, Matthew J. Meier, Juan Ochoteco Asensio, Timothy W. Gant, Weida Tong, Carole L. Yauk, Florian Caiment
Publikováno v: Regulatory Toxicology and Pharmacology, 131:105143. Elsevier Science
Despite the widespread use of transcriptomics technologies in toxicology research, acceptance of the data by regulatory agencies to support the hazard assessment is still limited. Fundamental issues contributing to this are the lack of reproducibilit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82f376829c82becb6249ff7d0571d340
https://pubmed.ncbi.nlm.nih.gov/35247516
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