Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Timothy Vartanian"'
Autor:
Yinghua Ma, David Sannino, Jennifer R. Linden, Sylvia Haigh, Baohua Zhao, John B. Grigg, Paul Zumbo, Friederike Dündar, Daniel Butler, Caterina P. Profaci, Kiel Telesford, Paige N. Winokur, Kareem R. Rumah, Susan A. Gauthier, Vincent A. Fischetti, Bruce A. McClane, Francisco A. Uzal, Lily Zexter, Michael Mazzucco, Richard Rudick, David Danko, Evan Balmuth, Nancy Nealon, Jai Perumal, Ulrike Kaunzner, Ilana L. Brito, Zhengming Chen, Jenny Z. Xiang, Doron Betel, Richard Daneman, Gregory F. Sonnenberg, Christopher E. Mason, Timothy Vartanian
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 9 (2023)
Multiple sclerosis (MS) is a complex disease of the CNS thought to require an environmental trigger. Gut dysbiosis is common in MS, but specific causative species are unknown. To address this knowledge gap, we used sensitive and quantitative PCR dete
Externí odkaz:
https://doaj.org/article/f0c0efe29a314b36bf138e14c6f076be
Autor:
Kiel M. Telesford, Lilyana Amezcua, Lauren Tardo, Lindsay Horton, Brett T. Lund, Anthony T. Reder, Timothy Vartanian, Nancy L. Monson
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
People identified with Black/African American or Hispanic/Latinx ethnicity are more likely to exhibit a more severe multiple sclerosis disease course relative to those who identify as White. While social determinants of health account for some of thi
Externí odkaz:
https://doaj.org/article/94b304e5599b4c28adc6436e6a611ec2
Autor:
Samantha V. Shetty, Michael R. Mazzucco, Paige Winokur, Sylvia V. Haigh, Kareem Rashid Rumah, Vincent A. Fischetti, Timothy Vartanian, Jennifer R. Linden
Publikováno v:
Toxins, Vol 15, Iss 7, p 423 (2023)
Clostridium perfringens epsilon toxin (ETX) is the third most lethal bacterial toxin and has been suggested to be an environmental trigger of multiple sclerosis, an immune-mediated disease of the human central nervous system. However, ETX cytotoxicit
Externí odkaz:
https://doaj.org/article/888a14a889c84693a63a1d03514c6b36
Autor:
Drew Adler, Jennifer R. Linden, Samantha V. Shetty, Yinghua Ma, Monika Bokori-Brown, Richard W. Titball, Timothy Vartanian
Publikováno v:
iScience, Vol 15, Iss , Pp 39-54 (2019)
Summary: Clostridium perfringens epsilon toxin (ETX) is hypothesized to mediate blood-brain barrier (BBB) permeability by binding to the myelin and lymphocyte protein (MAL) on the luminal surface of endothelial cells (ECs). However, the kinetics of t
Externí odkaz:
https://doaj.org/article/d559d06e4735453092ec67a885d9b724
Publikováno v:
Bio-Protocol, Vol 10, Iss 15 (2020)
In order for the brain to function properly, a carefully orchestrated homeostasis must be maintained. To help regulate this delicate balance, the brain has developed a highly selective blood-brain barrier (BBB). Under normal conditions, the BBB exclu
Externí odkaz:
https://doaj.org/article/0a1a194002194aec9c51367ffc93ccbf
Autor:
Jennifer R Linden, Claudia Flores, Eric F Schmidt, Francisco A Uzal, Adam O Michel, Marissa Valenzuela, Sebastian Dobrow, Timothy Vartanian
Publikováno v:
PLoS Pathogens, Vol 15, Iss 11, p e1008014 (2019)
Clostridium perfringens epsilon toxin (ETX) is responsible for causing the economically devastating disease, enterotoxaemia, in livestock. It is well accepted that ETX causes blood brain barrier (BBB) permeability, however the mechanisms involved in
Externí odkaz:
https://doaj.org/article/6babc98edc8c4f5e95ba4222ccf5b958
Autor:
Wendy S. Vargas, Elizabeth Monohan, Sneha Pandya, Ashish Raj, Timothy Vartanian, Thanh D. Nguyen, Sandra M. Hurtado Rúa, Susan A. Gauthier
Publikováno v:
NeuroImage: Clinical, Vol 9, Iss C, Pp 369-375 (2015)
Objectives: Investigating the potential of myelin repair strategies in multiple sclerosis (MS) requires an understanding of myelin dynamics during lesion evolution. The objective of this study is to longitudinally measure myelin water fraction (MWF),
Externí odkaz:
https://doaj.org/article/ceaf2356453b4e2596e5d88964429b7a
Autor:
Jennifer R. Linden, Kiel Telesford, Samantha Shetty, Paige Winokour, Sylvia Haigh, Ellen Cahir-McFarland, Giovanna Antognetti, Abhishek Datta, Tao Wang, Werner Meier, Timothy Vartanian
Publikováno v:
Antibodies, Vol 7, Iss 4, p 37 (2018)
The pore-forming epsilon toxin (ETX) produced by Clostridium perfringens is among the most lethal bacterial toxins known. Sensitive antibody-based reagents are needed to detect toxin, distinguish mechanisms of cell death, and prevent ETX toxicity. Us
Externí odkaz:
https://doaj.org/article/3d10856f453c49769bff5bff93b3c8ab
Autor:
Jennifer R. Linden, Yinghua Ma, Baohua Zhao, Jason Michael Harris, Kareem Rashid Rumah, Nicole Schaeren-Wiemers, Timothy Vartanian
Publikováno v:
mBio, Vol 6, Iss 3 (2015)
ABSTRACT Clostridium perfringens epsilon toxin (ε-toxin) is responsible for a devastating multifocal central nervous system (CNS) white matter disease in ruminant animals. The mechanism by which ε-toxin causes white matter damage is poorly understo
Externí odkaz:
https://doaj.org/article/306d1194de474fd3938cedd43eabcc8c
Autor:
Kareem Rashid Rumah, Yinghua Ma, Jennifer R Linden, Myat Lin Oo, Josef Anrather, Nicole Schaeren-Wiemers, Miguel A Alonso, Vincent A Fischetti, Mark S McClain, Timothy Vartanian
Publikováno v:
PLoS Pathogens, Vol 11, Iss 5, p e1004896 (2015)
Clostridium perfringens ε-toxin (ETX) is a potent pore-forming toxin responsible for a central nervous system (CNS) disease in ruminant animals with characteristics of blood-brain barrier (BBB) dysfunction and white matter injury. ETX has been propo
Externí odkaz:
https://doaj.org/article/48225ba227d4434f91fe017f57c9a149