Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Timothy Tapscott"'
Autor:
Liam Fitzsimmons, Lin Liu, Steffen Porwollik, Sangeeta Chakraborty, Prerak Desai, Timothy Tapscott, Calvin Henard, Michael McClelland, Andres Vazquez-Torres
Publikováno v:
PLoS Pathogens, Vol 14, Iss 10, p e1007388 (2018)
The metabolic processes that enable the replication of intracellular Salmonella under nitrosative stress conditions engendered in the innate response of macrophages are poorly understood. A screen of Salmonella transposon mutants identified the ABC-t
Externí odkaz:
https://doaj.org/article/26ed4efacd1e40d0bdf7d9903c5dd823
Autor:
Matthew A. Crawford, Timothy Tapscott, Liam F. Fitzsimmons, Lin Liu, Aníbal M. Reyes, Stephen J. Libby, Madia Trujillo, Ferric C. Fang, Rafael Radi, Andrés Vázquez-Torres
Publikováno v:
mBio, Vol 7, Iss 2 (2016)
ABSTRACT The four-cysteine zinc finger motif of the bacterial RNA polymerase regulator DksA is essential for protein structure, canonical control of the stringent response to nutritional limitation, and thiol-based sensing of oxidative and nitrosativ
Externí odkaz:
https://doaj.org/article/0410db42924e46a1af7e678f52990e9d
Autor:
Jessica Jones-Carson, Adrienne E Zweifel, Timothy Tapscott, Chad Austin, Joseph M Brown, Kenneth L Jones, Martin I Voskuil, Andrés Vázquez-Torres
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 8, p e3079 (2014)
Our investigations show that nonlethal concentrations of nitric oxide (NO) abrogate the antibiotic activity of β-lactam antibiotics against Burkholderia pseudomallei, Escherichia coli and nontyphoidal Salmonella enterica serovar Typhimurium. NO prot
Externí odkaz:
https://doaj.org/article/d538376c2f984f58979fc66846016b0c
Autor:
Ju-Sim Kim, Lin Liu, Andrés Vázquez-Torres, Matthew A. Crawford, Jessica Jones-Carson, Timothy Tapscott, Liam F. Fitzsimmons
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
The repressive activity of ancestral histone-like proteins helps integrate transcription of foreign genes with discrepant AT content into existing regulatory networks. Our investigations indicate that the AT-rich discriminator region located between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bc955ab2e8aa8b94ed2e07e0cb7cdb1
http://link.springer.com/article/10.1038/s41598-018-27780-9
http://link.springer.com/article/10.1038/s41598-018-27780-9
Publikováno v:
Applied and Environmental Microbiology
In this study, we targeted the development and evaluation of broad-host-range CRISPR/Cas9 gene-editing tools in order to enhance the genetic-engineering capabilities of an industrially relevant methanotrophic biocatalyst. The CRISPR/Cas9 system devel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::858851fbab1a741197bbe6bbce890e5d
http://europepmc.org/articles/PMC6532038
http://europepmc.org/articles/PMC6532038
Publikováno v:
Cell Host & Microbe. 20:144-153
For pathogenic bacteria, the ability to sense and respond to environmental stresses encountered within the host is critically important, allowing them to adapt to changing conditions and express virulence genes appropriately. This review considers th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d94ef46465d58fe1106d782b30072050
https://doi.org/10.1016/j.chom.2016.07.010
https://doi.org/10.1016/j.chom.2016.07.010
Publikováno v:
Cell Host & Microbe. 20:133-143
Pathogenic bacteria must withstand diverse host environments during infection. Environmental signals, such as pH, temperature, nutrient limitation, etc., not only trigger adaptive responses within bacteria to these specific stress conditions but also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd735e68f3e0788d50106be56155654
https://doi.org/10.1016/j.chom.2016.07.009
https://doi.org/10.1016/j.chom.2016.07.009
Autor:
Maroof Husain, Andrés Vázquez-Torres, Matthew A. Crawford, Harry Ischiropoulos, Paschalis-Thomas Doulias, Lin Liu, Calvin A. Henard, Steffen Porwollik, Timothy Tapscott, Michael McClelland
Publikováno v:
Molecular Microbiology. 91:790-804
Summary We show that thiols in the 4-cysteine zinc-finger motif of DksA, an RNA polymerase accessory protein known to regulate the stringent response, sense oxidative and nitrosative stress. Hydrogen peroxide- or nitric oxide (NO)-mediated modificati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9d1091c126213ff3edd15c337ea93eb
https://doi.org/10.1111/mmi.12498
https://doi.org/10.1111/mmi.12498
Publikováno v:
Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ad37edf0b3cb45517e0d22cb65a5984
https://doi.org/10.1002/9781119004813.ch93
https://doi.org/10.1002/9781119004813.ch93
Autor:
Andrés Vázquez-Torres, Madia Trujillo, Stephen J. Libby, Timothy Tapscott, Lin Liu, Rafael Radi, Matthew A. Crawford, Ferric C. Fang, Liam F. Fitzsimmons, Aníbal M. Reyes
Publikováno v:
mBio
mBio, Vol 7, Iss 2 (2016)
mBio, Vol 7, Iss 2, p e02161-15 (2016)
mBio, Vol 7, Iss 2 (2016)
mBio, Vol 7, Iss 2, p e02161-15 (2016)
The four-cysteine zinc finger motif of the bacterial RNA polymerase regulator DksA is essential for protein structure, canonical control of the stringent response to nutritional limitation, and thiol-based sensing of oxidative and nitrosative stress.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f94a8223b4459407291c6c7cc989cce
https://doi.org/10.1128/mbio.02161-15
https://doi.org/10.1128/mbio.02161-15