Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Timothy T. Curran"'
Publikováno v:
Synlett. 24:550-569
This account documents our recent progress in exposing some of the potential of mucohalic acids in synthetic applications. Understanding their stability and reactivity in different reaction media allows the development of mild and regioselective meth
Publikováno v:
Synthetic Communications. 42:1855-1863
Air oxidation of N-cyclopropylanilines was shown to occur under either ambient conditions or accelerated conditions (warming or shining light) in an open container. A subsequent fragmentation resulted in formation of the corresponding acetamide. Whil
Autor:
Anne Akin, Jacob Bradley Schwarz, Johnson Paul D, Peter G. Blazecka, Osuma Augustine Tobi, Derek Vrieze, Mark S. Plummer, Yun Huang, Ji Zhang, Michael Lovdahl, Norman L. Colbry, Brian Samas, Joseph Richard Bozelak, Timothy T. Curran, Andrew John Thorpe, Derek A. Pflum, Annise Paige Goodman, David C. Boyles, Garrett Hoge, Suzanne Ross Kesten
Publikováno v:
Tetrahedron Letters. 50:1167-1170
A chiral β-amino acid containing three contiguous chiral centers was synthesized efficiently in 11 steps, employing enantio-enriched β-ketoester as a key intermediate, via stereoselective catalytic hydrogenation of the corresponding enamide. Stereo
Autor:
Daniel Merritt Bowles, David C. Schineman, Markus Tamm, Kurtis G. Ritsema, Jonathan Mark Miller, William Keun Chan Park, David C. Boyles, Scott D. Larsen, Richard H. Hutchings, Timothy T. Curran, Gary Louis Bolton
Publikováno v:
Organic Process Research & Development. 12:1183-1187
Development work toward an enabling synthesis of preparative scale batches of an imidazole-based HMG-CoA reductase inhibitor is described. The desired target was synthesized in 16% yield over 7 steps, highlighted by an imidazole-forming condensation
Autor:
and Roger V. Parlett, Derek Vrieze, Timothy T. Curran, David C. Boyles, Vladimir Beylin, Dainius Macikenas
Publikováno v:
Organic Process Research & Development. 11:441-449
This paper describes the synthesis of two amino-quinazolinediones which are potent gyrase/topoisomerase inhibitors and useful as antibacterial agents. The early scale-up work to prepare a chiral side chain on multigram scale and two different amino-q
Publikováno v:
The Journal of Organic Chemistry. 72:3311-3318
Novel 5-(1'-hydroxy)-gamma-butyrolactone and gamma-butyrolactam subunits were synthesized by direct vinylogous aldol addition of alpha,beta-dichloro gamma-butyrolactones and gamma-butyrolactams with aldehydes under basic conditions. Different bases a
Publikováno v:
Tetrahedron Letters. 46:6433-6436
Novel and useful building blocks were synthesized efficiently by DABCO mediated highly selective dehalogenation of Knoevenagel aldol adducts of mucochloric acid and mucobromic acid. These new compounds were found to undergo palladium catalyzed C–C
Publikováno v:
Tetrahedron. 61:7807-7813
The indium(III) triflate mediated addition of active methylene compounds to terminal alkynes has been expanded to use malonates and low boiling terminal alkynes to form the Markovnikov addition products. Indium(III) chloride and indium(III) bromide w
Autor:
Timothy T. Curran, Anne Akin
Publikováno v:
Synthetic Communications. 35:1649-1661
The preparation of the 1β‐glucuronide of the diacid, CI‐1027, is described. The key synthetic steps are coupling of the mono‐protected acid with bromoglucuronide, deacetylation, and enzymatic hydrolysis.
Publikováno v:
Tetrahedron Letters. 46:2029-2032
The first Mukaiyama aldol reaction on mucohalic acid ( 1a / b ) has been achieved. Reaction of 1 with various ketene silyl acetals or silyl enol ethers in the presence of a Lewis acid provides the γ-substituted γ-butenolides in good to excellent yi