Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Timothy T Harden"'
Autor:
Ben J Vincent, Max V Staller, Francheska Lopez-Rivera, Meghan D J Bragdon, Edward C G Pym, Kelly M Biette, Zeba Wunderlich, Timothy T Harden, Javier Estrada, Angela H DePace
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007644 (2018)
Hunchback is a bifunctional transcription factor that can activate and repress gene expression in Drosophila development. We investigated the regulatory DNA sequence features that control Hunchback function by perturbing enhancers for one of its targ
Externí odkaz:
https://doaj.org/article/5083d378a6224632ac9d51e671b59a36
Autor:
Gene-Wei Li, Timothy T. Harden, Jeff Gelles, Jean-Benoît Lalanne, Jane Kondev, Ann Hochschild, Mathew Chamberlain, Karina S. Herlambang, Christopher D. Wells, Robert Landick
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
RNA polymerases (RNAPs) transcribe genes through a cycle of recruitment to promoter DNA, initiation, elongation, and termination. After termination, RNAP is thought to initiate the next round of transcription by detaching from DNA and rebinding a new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13b1e65a1dd0a55b276f4de8842b6cc
http://link.springer.com/article/10.1038/s41467-019-14208-9
http://link.springer.com/article/10.1038/s41467-019-14208-9
SUMMARYTranscription of developmental genes is controlled by multiple enhancers. Frequently, more than one enhancer can activate transcription from the same promoter in the same cells. In these cases, how is regulatory information from multiple enhan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07c39237db718113c40611f71922716d
Publikováno v:
Development (Cambridge, England)
During development, genes are transcribed at specific times, locations and levels. In recent years, the emergence of quantitative tools has significantly advanced our ability to measure transcription with high spatiotemporal resolution in vivo. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::160bd65eb9f7401f3f68f489bd50a623
https://pubmed.ncbi.nlm.nih.gov/29089359
https://pubmed.ncbi.nlm.nih.gov/29089359
Autor:
Javier Estrada, Francheska Lopez-Rivera, Kelly M. Biette, Max V. Staller, Ben J. Vincent, Edward C.G. Pym, Meghan D. J. Bragdon, Zeba Wunderlich, Angela H. DePace, Timothy T. Harden
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007644 (2018)
Hunchback is a bifunctional transcription factor that can activate and repress gene expression in Drosophila development. We investigated the regulatory DNA sequence features that control Hunchback function by perturbing enhancers for one of its targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c06fb67de244c3046ceb5c4f0bcc15f
https://pubmed.ncbi.nlm.nih.gov/30192762
https://pubmed.ncbi.nlm.nih.gov/30192762
Signal Integration by Shadow Enhancers and Enhancer Duplications Varies across the Drosophila Embryo
Publikováno v:
Cell Reports. 26:2407-2418.e5
Transcription of developmental genes is controlled by multiple enhancers. Frequently, more than one enhancer can activate transcription from the same promoter in the same cells. How is regulatory information from multiple enhancers combined to determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0a7ae2bcafea3902d5774cfac9b3292
https://doi.org/10.1016/j.celrep.2019.01.115
https://doi.org/10.1016/j.celrep.2019.01.115
Autor:
Robert Landick, Jeff Gelles, Timothy T. Harden, Christopher D. Wells, Jane Kondev, Ann Hochschild, Larry J. Friedman
Production of a messenger RNA proceeds through sequential stages of transcription initiation and transcript elongation and termination. During each of these stages, RNA polymerase (RNAP) function is regulated by RNAP-associated protein factors. In ba
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01e2ec5f63c987b3f44af6b3a33370ce
https://europepmc.org/articles/PMC4725480/
https://europepmc.org/articles/PMC4725480/
Autor:
Christopher D. Wells, Timothy T. Harden, Ann Hochschild, Jane Kondev, Larry J. Friedman, Jeff Gelles
Publikováno v:
Biophysical Journal. 108:535a
Production of a messenger RNA proceeds through sequential stages of transcription initiation, transcript elongation and termination; all three stages are regulated to control gene expression. As RNA polymerases (RNAPs) transition to elongation, they
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad81904622f4a1405076a9a94294258
https://doi.org/10.1016/j.bpj.2014.11.2933
https://doi.org/10.1016/j.bpj.2014.11.2933
Autor:
Timothy T. Harden, Karina S. Herlambang, Mathew Chamberlain, Jean-Benoît Lalanne, Christopher D. Wells, Gene-Wei Li, Robert Landick, Ann Hochschild, Jane Kondev, Jeff Gelles
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
In the canonical bacterial transcription, both nascent transcript and polymerase dissociate from template DNA. By employing multi-color single-molecule fluorescence imaging, here the authors show that RNA polymerases remain bound to DNA after the tra
Externí odkaz:
https://doaj.org/article/13f680680f904593b7b3498bafa4968b