Výsledky vyhledávání - "Timothy Starosta"

Akademický článek

Protein Kinase C Inhibition With Ruboxistaurin Increases Contractility and Reduces Heart Size in a Swine Model of Heart Failure With Reduced Ejection Fraction

Autor: Thomas E. Sharp, III, BA, Hajime Kubo, PhD, Remus M. Berretta, BS, Timothy Starosta, BS, Markus Wallner, MD, PhD, Giana J. Schena, BS, Alexander R. Hobby, BS, Daohai Yu, PhD, Danielle M. Trappanese, PhD, Jon C. George, MD, Jeffery D. Molkentin, PhD, Steven R. Houser, PhD

Publikováno v: JACC: Basic to Translational Science, Vol 2, Iss 6, Pp 669-683 (2017)

Inotropic support is often required to stabilize the hemodynamics of patients with acute decompensated heart failure; while efficacious, it has a history of leading to lethal arrhythmias and/or exacerbating contractile and energetic insufficiencies.

Externí odkaz: https://doaj.org/article/dd3c3f7a8fed47668b3c56e6c1ad9062

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Unique Features of Cortical Bone Stem Cells Associated With Repair of the Injured Heart

Autor: Neil Zalavadia, Shavonn C. Smith, Sadia Mohsin, Remus M. Berretta, Yan Zhou, Jason M. Duran, Thomas E. Sharp, Timothy Starosta, Hajime Kubo, Steven R. Houser, Constantine D Troupes, Elorm J Agra

Publikováno v: Circulation Research. 117:1024-1033

Rationale: Adoptive transfer of multiple stem cell types has only had modest effects on the structure and function of failing human hearts. Despite increasing the use of stem cell therapies, consensus on the optimal stem cell type is not adequately d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e383efef977bb8c6a80296022f5c600
https://doi.org/10.1161/circresaha.115.307362

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Autologous c-Kit+ Mesenchymal Stem Cell Injections Provide Superior Therapeutic Benefit as Compared to c-Kit+ Cardiac-Derived Stem Cells in a Feline Model of Isoproterenol-Induced Cardiomyopathy

Autor: Jason M. Duran, Catherine A. Makarewich, Mary F. Barbe, E B S Thomas Sharp Iii, Sharven Taghavi, B S Hajime Kubo, M B S Remus Berretta, Timothy Starosta, Steven R. Houser

Publikováno v: Clinical and Translational Science. 8:425-431

Background Cardiac- (CSC) and mesenchymal-derived (MSC) CD117+ isolated stem cells improve cardiac function after injury. However, no study has compared the therapeutic benefit of these cells when used autologously. Methods MSCs and CSCs were isolate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4f0bdf5160afdeeb3003ffec29da4e09
https://doi.org/10.1111/cts.12251

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T-type Ca2+ channels regulate the exit of cardiac myocytes from the cell cycle after birth

Autor: Hui Gao, Xiaoxuan Fan, Timothy Starosta, Ying Li, Catherine A. Makarewich, Xiongwen Chen, Steven R. Houser, Jeffrey D. Molkentin, Remus M. Berretta, Fang Wang, Thomas E. Sharp, Hongyu Zhang, Hajime Kubo

Publikováno v: Journal of molecular and cellular cardiology

T-type Ca 2 + channels (TTCCs) are expressed in the fetal heart and then disappear from ventricular myocytes after birth. The hypothesis examined in this study was the α1G TTCCs' influence in myocyte maturation and their rapid withdrawal from the ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126428806758d356119bd6a4b1f9db1c

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Abstract 364: Cortical Bone Stem Cells Derived Exosomes as Potent Modulator of Cardiac Immune Response and Repair After Injury

Autor: Hajime Kubo, Steven R. Houser, Constantine D Troupes, Mohsin Khan, Jaslyn Johnson, Timothy Starosta, Yijun Yang, Sadia Mohsin, Jennifer Petovic, Remus M. Berretta

Publikováno v: Circulation Research. 119

Rationale: Cortical bone derived stem cells (CBSCs) are known to have improved growth kinetics and myocardial repair properties that are superior to other known stem cell types used. Salutary effects of CBSCs in large are mediated by paracrine secret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4660a57f7643f03f1fe17374c77de414
https://doi.org/10.1161/res.119.suppl_1.364

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Abstract 28: Automated Characterization and Quantification of Cardiomyocyte Proliferation and Apoptosis in Post Myocardial Infarction Tissue Images

Autor: Nicolas Honnorat, Steven R. Houser, Jason M. Duran, Christos Davatzikos, Polina Gross, Erdem Varol, Thomas E. Sharp, Danielle M. Trappanese, Sarah Koller, Timothy Starosta, Markus Wallner

Publikováno v: Circulation Research. 119

Detection of cardiac cell death and cardiomyocyte (CM) proliferation after ischemic injury often hinges on quantitative image analysis of cardiac histopathology. Currently, the analysis of cardiac images has greatly relied on manual measurements of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::572d50fc72fb85c9072ddf876055569f
https://doi.org/10.1161/res.119.suppl_1.28

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Abstract 2: Cortical Bone Stem Cells Derived Exosomes as Potent Modulator of Cardiac Immune Response and Repair After Injury

Autor: Sadia Mohsin, Constantine D Troupes, Mohsin Khan, Yijun Yang, Jaslyn Johnson, Jennifer L Petovic, Timothy Starosta, Remus M Berretta, Hajime Kubo, Steven R Houser

Publikováno v: Circulation Research. 119

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bfc1bbfd04ba382fe274dcdd8485b130
https://doi.org/10.1161/res.119.suppl_1.2

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Abstract 296: Loss of Trpc6 Function in Cardiomyocytes Improves Survival and Attenuates Progression of Cardiac Dysfunction After Mi

Autor: Amir Toib, Polina Gross, Markus Wallner, Xiaoxiao Zhang, Tao Wang, Timothy Starosta, Steven R. Houser, Xiongwen Chen, Daohai Yu

Publikováno v: Circulation Research. 119

Ischemic heart disease (IHD) commonly culminates in myocardial infarction (MI), which causes cardiac myocyte death and depressed cardiac pump function. Surviving myocytes can usually maintain pump function by increasing Ca 2+ influx and contractility

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::944b1108303ad738b586ab62fb9cc927
https://doi.org/10.1161/res.119.suppl_1.296

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Acute Catecholamine Exposure Causes Reversible Myocyte Injury Without Cardiac Regeneration

Publikováno v: Circulation research. 119(7)

Rationale: Catecholamines increase cardiac contractility, but exposure to high concentrations or prolonged exposures can cause cardiac injury. A recent study demonstrated that a single subcutaneous injection of isoproterenol (ISO; 200 mg/kg) in mice

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3ed01e5451ef0758e105f5e827e1d19
https://pubmed.ncbi.nlm.nih.gov/27635079

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Nuquantus: Machine learning software for the characterization and quantification of cell nuclei in complex immunofluorescent tissue images

Autor: Nicolas Honnorat, Timothy Starosta, Jason M. Duran, Steven R. Houser, Polina Gross, Christos Davatzikos, Sarah Koller, Erdem Varol, Danielle M. Trappanese, Thomas E. Sharp, Markus Wallner

Publikováno v: Scientific Reports

Determination of fundamental mechanisms of disease often hinges on histopathology visualization and quantitative image analysis. Currently, the analysis of multi-channel fluorescence tissue images is primarily achieved by manual measurements of tissu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0570aaa2e3b08074a79e5373ffbb39fa
http://arxiv.org/abs/1512.04370

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