Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Timothy Smallie"'
Autor:
Andrew Nesbitt, R Cartwright, Hill Gaston, Helen Lockstone, Pierre Quartier, Karim Raza, Costantino Pitzalis, R Preiss, Nikunjana A. Patel, Natasha Sahgal, Louisa E. Jeffery, Tracy Hussell, Jane C. Goodall, Louise McNeill, Marc Feldmann, Marco Gattorno, Andrew Filer, Yuti Chernajovsky, Kieron S. Leslie, Lou Ellis, Jim Middleton, Saba Alzabin, Ayman Askari, Jennifer A. Smith, Eric Hachulla, J Hoyer, David M. Sansom, Helen J. Lachmann, Gianluca Fossati, Mark Peakman, Isabelle Koné-Paut, Philip N. Hawkins, Gayatri Mittal, J. B. Kuemmerle-Deschner, Katrina Blazek, Paolo Pozzilli, Michele Bombardi, A Widmer, Timothy Smallie, Thomas Krausgruber, Irina A. Udalova, Ahmet Gül, Rizgar A. Mageed, Elisa Astorri, Catherine Whittall
Background: Activities of the anti-TNFs, certolizumab pegol (CZP), etanercept (ETA), infliximab (IFX) and adalimumab (ADA), have been compared in a range of in vitro assays. CZP is the only licensed PEGylated Fab' anti-TNF; ETA is a fusion protein wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fef740867bf37a3acfc7df12af47c033
http://doc.rero.ch/record/300594/files/ker035.pdf
http://doc.rero.ch/record/300594/files/ker035.pdf
Autor:
Rafał Szatanek, Marek Zembala, Monika Baj-Krzyworzeka, Kazimierz Weglarczyk, Marzena Lenart, Maciej Siedlar, Timothy Smallie, Magdalena Rutkowska-Zapała, Löms Ziegler-Heitbrock
Tumor-derived microvesicles (TMV) can mimic effects of tumor cells leading to an increased anti-inflammatory cytokine production, such as interleukin 10 (IL-10), by tumor-infiltrating monocytes and macrophages. Yet, the mechanism of IL-10 induction b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a44068e2847f15ed2b0c0f8a437b3b
https://ruj.uj.edu.pl/xmlui/handle/item/94649
https://ruj.uj.edu.pl/xmlui/handle/item/94649
Autor:
Tracy Hussell, Marc Feldmann, Thomas Krausgruber, Helen Lockstone, Irina A. Udalova, Saba Alzabin, Katrina Blazek, Timothy Smallie, Natasha Sahgal
Publikováno v:
Nature Immunology. 12:231-238
Polymorphisms in the gene encoding the transcription factor IRF5 that lead to higher mRNA expression are associated with many autoimmune diseases. Here we show that IRF5 expression in macrophages was reversibly induced by inflammatory stimuli and con
Autor:
Bettina Kempkes, Claudia Unterberger, Max Koeppel, Brian M. J. Foxwell, Loems Ziegler-Heitbrock, Marion Frankenberger, Thomas Höfer, Marion Lohrum, Henk Stunnenberg, Timothy Smallie, Karl J. Staples, Lynn M. Williams, Annette Schaefer
Publikováno v:
Molecular Immunology, 45, 3230-3237
Molecular Immunology, 45, 11, pp. 3230-3237
Molecular Immunology, 45, 11, pp. 3230-3237
In the present report we have determined the molecular mechanisms, which govern the expression of the human IL-10 gene when induced by the glucocorticoid Methyl-Prednisolone (MP). Treatment of cells with MP at 10(-6) M will readily induce IL-10 in CD
Autor:
Ahmed Al-Obaidi, Brian M. J. Foxwell, Loems Ziegler-Heitbrock, Natalie J. Garton, Graham R. Stewart, Rebecca J. Smith, Adrian R. Martineau, Katalin A. Wilkinson, Peter W. Andrew, Sandra M. Newton, Kumar Rajakumar, Timothy Smallie, Jamila Shafi, John Wain, Robert J. Wilkinson, Mark P. Nicol, Michael R. Barer, Karl J. Staples, Beate Kampmann, Sarah Elizabeth Fandrich
Publikováno v:
Proceedings of the National Academy of Sciences. 103:15594-15598
Six major lineages ofMycobacterium tuberculosisappear preferentially transmitted amongst distinct ethnic groups. We identified a deletion affectingRv1519in CH, a strain isolated from a large outbreak in Leicester U.K., that coincidentally defines the
Autor:
Marzena, Lenart, Magdalena, Rutkowska-Zapala, Monika, Baj-Krzyworzeka, Rafał, Szatanek, Kazimierz, Węglarczyk, Timothy, Smallie, Löms, Ziegler-Heitbrock, Marek, Zembala, Maciej, Siedlar
Publikováno v:
Immunobiology. 222(1)
Tumor-derived microvesicles (TMV) can mimic effects of tumor cells leading to an increased anti-inflammatory cytokine production, such as interleukin 10 (IL-10), by tumor-infiltrating monocytes and macrophages. Yet, the mechanism of IL-10 induction b
Publikováno v:
Immunology. 113:281-292
Efforts to identify the signal transduction pathways used by interleukin-10 (IL-10) have resulted in limited success. The anti-inflammatory effects elicited by IL-10, and the mechanisms by which these are mediated, are still relatively unknown. Under
Autor:
Luciene Lopes, Sarah Karrar, Helen M. Rowe, Sofia Efklidou, Mary Collins, Timothy Smallie, Najmeeyah Brown, Paul M. Kaye
Lentiviral vectors deliver antigens to dendritic cells (DCs) in vivo, but they do not trigger DC maturation. We therefore expressed a viral protein that constitutively activates NF-κB, vFLIP from Kaposi's sarcoma-associated herpesvirus (KSHV), in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2ed231a8763f954ec7ee2d88c8eb65
https://europepmc.org/articles/PMC2643792/
https://europepmc.org/articles/PMC2643792/
IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3
Autor:
Bernard Burke, Timothy Smallie, Lynn M. Williams, Brian M. J. Foxwell, Loems Ziegler-Heitbrock, Andrew D. Foey, Karl J. Staples
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 178(8)
IL-10 is an important immunosuppressive cytokine that can down-regulate expression of other cytokines and has been shown to down-regulate itself. We show, in this study, that treatment of human monocyte-derived macrophages with IL-10 induces IL-10 mR
Autor:
Graham R. Stewart, Adrian R. Martineau, A. Al-Obaid, Brian M. J. Foxwell, Robert J. Wilkinson, Katalin A. Wilkinson, Mark P. Nicol, Natalie J. Garton, Löms Ziegler-Heitbrock, Peter W. Andrew, Timothy Smallie, Karl J. Staples, Rebecca J. Smith, Kumar Rajakumar, Michael R. Barer, J.R. Wain, Sarah Elizabeth Fandrich, Jamila Shafi, Sandra M. Newton
Publikováno v:
Journal of Infection. 54:e188-e189