Výsledky vyhledávání - "Timothy Secomb"

Novel method for kinetic analysis applied to transport by the uniporter OCT2

Publikováno v: American Journal of Physiology-Renal Physiology. 323:F370-F387

The kinetics of solute transport shed light on the roles these processes play in cellular physiology, and the absolute values of the kinetic parameters that quantitatively describe transport are increasingly used to model its impact on drug clearance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca8977f3e7e4ed607fa7fec696783ce
https://doi.org/10.1152/ajprenal.00106.2022

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The dependence of maximum oxygen uptake on hemoglobin-oxygen affinity and altitude: a computational modeling approach

Autor: Kevin Webb, Chad Wiggins, Timothy Secomb, Michael Joyner, Tuhin Roy

Publikováno v: Physiology. 38

Background: Hemoglobin, the primary oxygen-carrying protein in humans, provides the intermediate link between pulmonary oxygen uptake and tissue oxygen consumption. Oxygen transport is greatly influenced by the hemoglobin-oxygen affinity, which is co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b732cf4cf6f5b61d5d39c63eec14d52
https://doi.org/10.1152/physiol.2023.38.s1.5716173

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Role of potassium ion diffusion from neurons to capillaries in neurovascular coupling: effects of astrocytic endfeet geometry

Autor: Sara Djurich, Timothy Secomb

Publikováno v: Physiology. 38

Neurovascular coupling (NVC) refers to a local increase in cerebral blood flow (CBF) in response to increased neuronal activity. Diffusion of K+ released by neurons through the extracellular space (ECS) to capillaries may contribute to NVC. Increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f29ee1f43bdf300e1d992e7ddbf13391
https://doi.org/10.1152/physiol.2023.38.s1.5731717

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Functional implications of microvascular heterogeneity for oxygen uptake and utilization

Autor: Tuhin K Roy, Timothy Secomb

Publikováno v: Physiological Reports. 10

In the vascular system, an extensive network structure provides convective and diffusive transport of oxygen to tissue. In the microcirculation, parameters describing network structure, blood flow, and oxygen transport are highly heterogeneous. This

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18210626ddd81e4cc6a60b316be97552
https://doi.org/10.14814/phy2.15303

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Hemodynamics

Autor: Timothy Secomb

A review is presented of the physical principles governing the distribution of blood flow and blood pressure in the vascular system. The main factors involved are the pulsatile driving pressure generated by the heart, the flow characteristics of bloo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e4e6745206ed398c423380c59cfe25c
https://europepmc.org/articles/PMC4958049/

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