Výsledky vyhledávání - "Timothy Scott Fisher"

Akademický článek

Thermionic and Photo-excited Electron Emission for Energy Conversion Processes

Autor: Patrick T. McCarthy, Ronald G. Reifenberger, Timothy Scott Fisher

Publikováno v: Frontiers in Energy Research, Vol 2 (2014)

This article describes advances in thermionic and photoemission materials and applications dating back to the work on thermionic emission by Guthrie in 1873 and the photoelectric effect by Hertz in 1887. Thermionic emission has been employed for elec

Externí odkaz: https://doaj.org/article/ad4505c47dad4697b3f54bb7c753fc19

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Molecular imaging reveals biodistribution of P-cadherin LP-DART bispecific and trafficking of adoptively transferred T cells in mouse xenograft model

Autor: Timothy Scott Fisher, Tracey Clark, Rand Norberg, Vijay Gupta, Chad May, Anand Giddabasappa, Justin Cohen, John David, Adam Root

Publikováno v: Oncotarget

P-cadherin-LP-DART is a bispecific antibody targeting P-cadherin expressed on the tumor cells and CD3 on the T-cells. Previously we demonstrated the development and efficacy of P-cadherin-LP-DART in in vitro and in vivo models. Here, we evaluated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18a5b8bca1a2e5873f68b91840684f76
https://doi.org/10.18632/oncotarget.27544

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FcγRIIB engagement drives agonistic activity of Fc-engineered αOX40 antibody to stimulate human tumor-infiltrating T cells

Publikováno v: Journal for ImmunoTherapy of Cancer, 8(2):000816. BioMed Central Ltd.
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

BackgroundOX40 (CD134) is a costimulatory molecule of the tumor necrosis factor receptor superfamily that is currently being investigated as a target for cancer immunotherapy. However, despite promising results in murine tumor models, the clinical ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d3767bcd457655fb8a2181aa857e8ae
https://pure.eur.nl/en/publications/e71ad835-6f0e-4dad-86a9-c7b601739007

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A CD3-bispecific molecule targeting P-cadherin demonstrates T cell-mediated regression of established solid tumors in mice

Autor: Timothy Scott Fisher, Jonathan Golas, Justin Lucas, Lioudmila Tchistiakova, Chad May, Rohner Allison Karlyn, Hui Wang, Mark William Elliott, Adam Root, Konstantinos Tsaparikos, Tracey Clark, Nahor Haddish-Berhane, Hans-Peter Gerber, Andrea T. Hooper, Maria Gavriil, Bryan Peano

Publikováno v: Cancer Immunology, Immunotherapy. 67:247-259

Strong evidence exists supporting the important role T cells play in the immune response against tumors. Still, the ability to initiate tumor-specific immune responses remains a challenge. Recent clinical trials suggest that bispecific antibody-media

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16cb9dbe819096f45e81b9a3e5eeeab3
https://doi.org/10.1007/s00262-017-2081-0

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HPK1 Influences Regulatory T Cell Functions

Autor: Renyuan Zha, Saba Alzabin, Timothy Scott Fisher, Steven J. Burakoff, Sansana Sawasdikosol

Publikováno v: ImmunoHorizons. 4(7)

Hematopoietic progenitor kinase 1 (HPK1) is a negative regulator of TCR-initiated signal transduction. Both the HPK1−/− mice and the genetically engineered mice with a point mutation that disrupts the catalytic activity of HPK1 possess enhanced a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c41a4d78bf040446ac7dfb24a11132
https://pubmed.ncbi.nlm.nih.gov/32631900

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Multiple conformational states of the HPK1 kinase domain in complex with sunitinib reveal the structural changes accompanying HPK1 trans-regulation

Autor: Sergei Timofeevski, Sansana Sawasdikosol, Timothy Scott Fisher, Steven J. Burakoff, Robert Steven Kania, Ted William Johnson, Gallego Rebecca Anne, Ciarán N. Cronin, Eric Johnson, Michele McTigue, Michael F. Maestre

Publikováno v: J Biol Chem

Hematopoietic progenitor kinase 1 (HPK1 or MAP4K1) is a Ser/Thr kinase that operates via the c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) signaling pathways to dampen the T-cell response and antitumor immunity. Accord

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2e631e4c6e59e5e24c0fc88c0ab0bcb
https://pubmed.ncbi.nlm.nih.gov/31018963

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Luciferase does not alter metabolism in cancer cells

Autor: Peter J. O'Brien, Caroline H. Johnson, Brunhilde H. Felding, Timothy Scott Fisher, Linh Hoang, Gary Siuzdak

Publikováno v: Metabolomics. 10:354-360

Luciferase transfected cell lines are used extensively for cancer models, revealing valuable biological information about disease mechanisms. However, these genetically encoded reporters, while useful for monitoring tumor response in cancer models, c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64280d782b133b2d6a4346622eec9a7
https://doi.org/10.1007/s11306-014-0622-5

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Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity

Autor: Chunli Huang, Paul D. Lira, Love Victoria Alexandria, Oliphant Theodore Lawrence, Leslie L. Sharp, Sharon A. Sokolowski, Simon Bergqvist, Amy C. Shen, Rohner Allison Karlyn, Timothy Scott Fisher, Sangita M. Baxi, Regis Doyonnas, Cris Kamperschroer

Publikováno v: Cancer Immunology, Immunotherapy. 61:1721-1733

4-1BB (CD137, TNFRSF9) is a costimulatory receptor expressed on several subsets of activated immune cells. Numerous studies of mouse and human T cells indicate that 4-1BB promotes cellular proliferation, survival, and cytokine production. 4-1BB agoni

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f3fc7a38b6995c75983c89b2c853aaf
https://doi.org/10.1007/s00262-012-1237-1

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Analysis of the role of the HIF hydroxylase family members in erythropoiesis

Autor: David G. Perregaux, Timothy Scott Fisher, William H. Brissette, Paul D. Lira, Jeffrey L. Stock, Baiyong Li, Terence R.S. Ozolinš

Publikováno v: Biochemical and Biophysical Research Communications. 388:683-688

HIF (hypoxia-inducible factor) hydroxylases have been implicated in EPO (erythropoietin) production and erythropoiesis. Here we examined the role of each of the three EGLN family members and the HIF asparaginyl hydroxylase FIH (factor inhibiting HIF)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e7dc526cd118614f1f3d5562f017f3
https://doi.org/10.1016/j.bbrc.2009.08.058

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