Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Timothy S. Strutzenberg"'
Autor:
Shanwen Zhang, Qian Ren, Scott J. Novick, Timothy S. Strutzenberg, Patrick R. Griffin, Huan Bao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Circularised nanodiscs (cNDs) are able to stabilise large lipid bilayer patches and are used for structural and functional studies. Current techniques to build cNDs have numerous steps and low yields; here the authors report a single step constructio
Externí odkaz:
https://doaj.org/article/abcf045a3b4d48039b28f9381ec9e24a
Autor:
Timothy S Strutzenberg, Ruben D Garcia-Ordonez, Scott J Novick, HaJeung Park, Mi Ra Chang, Christelle Doebellin, Yuanjun He, Rémi Patouret, Theodore M Kamenecka, Patrick R Griffin
Publikováno v:
eLife, Vol 8 (2019)
Externí odkaz:
https://doaj.org/article/b1fd8e202dc64662880de54a651a8517
Autor:
Timothy S Strutzenberg, Ruben D Garcia-Ordonez, Scott J Novick, HaJeung Park, Mi Ra Chang, Christelle Doebellin, Yuanjun He, Rémi Patouret, Theodore M Kamenecka, Patrick R Griffin
Publikováno v:
eLife, Vol 8 (2019)
Members of the nuclear receptor (NR) superfamily regulate both physiological and pathophysiological processes ranging from development and metabolism to inflammation and cancer. Synthetic small molecules targeting NRs are often deployed as therapeuti
Externí odkaz:
https://doaj.org/article/7598ee1869b74d83a7b3c7b8c0a9b36c
Autor:
Xiao-Nan Zhang, Albert T. Lam, Qinqin Cheng, Valentine V. Courouble, Timothy S. Strutzenberg, Jiawei Li, Yiling Wang, Hua Pei, Bangyan L. Stiles, Stan G. Louie, Patrick R. Griffin, Yong Zhang
Publikováno v:
Chemical Science. 13:1982-1991
An analogue of nicotinamide adenine dinucleotide (NAD+) featuring an azido group at 3′-OH of adenosine moiety is found to possess high specificity for human PARP1-catalyzed protein poly-ADP-ribosylation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80b2556a81a7d60c2cd22cf81c72bedf
https://doi.org/10.1039/d1sc06256e
https://doi.org/10.1039/d1sc06256e
Autor:
Dipak N. Patil, Shikha Singh, Thibaut Laboute, Timothy S. Strutzenberg, Xingyu Qiu, Di Wu, Scott J. Novick, Carol V. Robinson, Patrick R. Griffin, John F. Hunt, Tina Izard, Appu K. Singh, Kirill A. Martemyanov
Publikováno v:
Science
Not your typical GPCR Among the large family of G protein–coupled receptors (GPCRs) are many orphans, so called because their signaling reactions remain poorly understood. Among these is GPR158 which is highly expressed in the nervous system and im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493ed2eac91bdbd9a1a19a0ab84f5be4
https://pubmed.ncbi.nlm.nih.gov/34793198
https://pubmed.ncbi.nlm.nih.gov/34793198
Autor:
Min Li, Dario Oliveira Passos, Zelin Shan, Steven J. Smith, Qinfang Sun, Avik Biswas, Indrani Choudhuri, Timothy S. Strutzenberg, Allan Haldane, Nanjie Deng, Zhaoyang Li, Xue Zhi Zhao, Terrence R. Burke, Ronald M. Levy, Stephen H. Hughes, Robert Craigie, Dmitry Lyumkis
HIV-1 infection depends on the integration of viral DNA into host chromatin. Integration is mediated by the viral enzyme integrase and is blocked by integrase strand transfer inhibitors (INSTIs), first-line antiretroviral therapeutics widely used in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b022e35fdbb4b4f0aca4b1b42b17445a
https://doi.org/10.1101/2022.12.04.519057
https://doi.org/10.1101/2022.12.04.519057
Autor:
Sarah A. Mosure, Paola Munoz-Tello, Kuang-Ting Kuo, Brian MacTavish, Xiaoyu Yu, Daniel Scholl, Christopher C. Williams, Timothy S. Strutzenberg, Jared Bass, Richard Brust, Ashok A. Deniz, Patrick R. Griffin, Douglas J. Kojetin
PPARγ is a nuclear receptor transcription factor that regulates adipogenic and insulin sensitizing gene programs via two activation function (AF) regulatory domains: a ligand-dependent AF-2 coregulator interaction surface within the C-terminal ligan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1391d8be19b46ea8fd2251bbc5a88fd
https://doi.org/10.1101/2022.07.13.499031
https://doi.org/10.1101/2022.07.13.499031
Publikováno v:
Journal of Visualized Experiments.
Single-particle analysis (SPA) by cryo-electron microscopy (cryo-EM) is now a mainstream technique for high-resolution structural biology. Structure determination by SPA relies upon obtaining multiple distinct views of a macromolecular object vitrifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3eb92efd6ffadf1c23f3f4331e543b1
https://doi.org/10.3791/64136
https://doi.org/10.3791/64136
Autor:
Patrick R. Griffin, Michael Farzan, Louis Scampavia, Emery Smith, Pierre Baillargeon, Tu Trinh Nguyen, Mitchell V. Hull, Timothy S. Strutzenberg, Meredith E. Davis-Gardner, Ruben D. Garcia-Ordonez, Timothy P. Spicer, Emily Chen
Publikováno v:
SLAS Discovery. 25:1152-1161
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in late 2019 has triggered an ongoing global pandemic whereby infection may result in a lethal severe pneumonia-like disease designated as coronavirus disease 2019 (COVID-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b296a8834eb316f6af8b2cb7bdd7394
https://doi.org/10.1177/2472555220963667
https://doi.org/10.1177/2472555220963667
Autor:
Jie Zheng, Adrian Reich, Ruben D. Garcia-Ordonez, Timothy S. Strutzenberg, Venkatasubramanian Dharmarajan, Patrick R. Griffin, Bruce D. Pascal, Gogce Crynen, Scott J. Novick
Publikováno v:
Analytical Chemistry. 92:11018-11028
Hydrogen/Deuterium Exchange (HDX) coupled with Mass Spectrometry (HDX-MS) is a sensitive and robust method to probe protein conformational changes and protein-ligand interactions. HDX-MS relies on successful proteolytic digestion of target proteins u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f487aaf11f55324559ec7dd8fcf25162
https://doi.org/10.1021/acs.analchem.9b05694
https://doi.org/10.1021/acs.analchem.9b05694