Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Timothy S. Schaefer"'
Autor:
Zhiyong Ren, Timothy S. Schaefer
Publikováno v:
BioTechniques, Vol 31, Iss 6, Pp 1254-1258 (2001)
Externí odkaz:
https://doaj.org/article/9f166f23b81143118b5dfe908ab093b4
Publikováno v:
BioTechniques, Vol 31, Iss 1, Pp 196-202 (2001)
In an initial effort to determine the effect of expressing potentially therapeutic gene products on the growth properties of glioma tumor xenografts, we describe the development of cell lines that can conditionally express β-galactosidase (β-gal).
Externí odkaz:
https://doaj.org/article/99adf0d7c7ac411485d6ee76a3e558af
Publikováno v:
Molecular Biology Reports. 31:13-21
Stats are latent transcription factors involved in normal cellular signaling in response to cytokine or growth factor stimulation. Constitutive activation of Stats (primarily Stat3 and Stat5) has been implicated in growth dysregulation and oncogenesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec413608c132776c2e4304216071557a
https://doi.org/10.1023/b:mole.0000013503.16301.82
https://doi.org/10.1023/b:mole.0000013503.16301.82
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:633-636
Stat3 is a latent transcription factor that exhibits elevated activity in a variety of human cancers. To find a lead peptide for peptidomimetic drug development we synthesized and tested phosphopeptides derived from known receptor docking sites and f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546b317e1763f40101cfa69a633851c7
https://doi.org/10.1016/s0960-894x(02)01050-8
https://doi.org/10.1016/s0960-894x(02)01050-8
Autor:
Timothy S. Schaefer, Zhiyong Ren
Publikováno v:
Journal of Biological Chemistry. 277:38486-38493
Stats (signal transducer and activator of transcription) are latent transcription factors that translocate from the cytoplasm to the nucleus. Constitutive activation of Stat3 alpha by upstream oncoproteins and receptor tyrosine kinases has been found
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83d9eecbcaaa3b5e6c4f4d71e72e3324
https://doi.org/10.1074/jbc.m112438200
https://doi.org/10.1074/jbc.m112438200
Publikováno v:
Oncogene. 21:2058-2065
Members of the normally latent family of transcription factors signal/inducers and activators of transcription (Stat) are activated in a number of human tumors and tumor-derived cell lines. In the case of Stat3, it is believed that this activation le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e019029496a74601e8e7a6c1468f976d
https://doi.org/10.1038/sj.onc.1205263
https://doi.org/10.1038/sj.onc.1205263
Autor:
Timothy S. Schaefer, Zhiyong Ren
Publikováno v:
BioTechniques. 31:1254-1258
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ae675a5afdcfad3eb5afed53d9df9f5
https://doi.org/10.2144/01316bm05
https://doi.org/10.2144/01316bm05
Publikováno v:
BioTechniques. 31:196-202
In an initial effort to determine the effect of expressing potentially therapeutic gene products on the growth properties of glioma tumor xenografts, we describe the development of cell lines that can conditionally express β-galactosidase (β-gal).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7340145b9a57ed20e34e3bc981b2395a
https://doi.org/10.2144/01311dd04
https://doi.org/10.2144/01311dd04
Publikováno v:
Cytokine. 12:1647-1655
In this study we explored the activation of the JAK/Stat pathway by gp 130 family cytokines in primary human astrocytes. We report that of four gp 130 cytokines tested, only oncostatin M (OnM) resulted in the activation of Stat molecules. To test tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3976b7462f210b9291e8a1ff253baf1
https://doi.org/10.1006/cyto.2000.0774
https://doi.org/10.1006/cyto.2000.0774
Publikováno v:
Biochemical and Biophysical Research Communications. 266:481-487
Stat3 proteins are constitutively activated in cells transformed by v-Src and the proteins have been shown to interact directly. Subsequent studies have shown that Stat3 is required for cellular transformation of NIH fibroblasts by v-Src, suggesting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46c3e05031ce940816c8594c1855c8cc
https://doi.org/10.1006/bbrc.1999.1853
https://doi.org/10.1006/bbrc.1999.1853