Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Timothy S. Gardner"'
Publikováno v:
Emerging Topics in Life Sciences
Since the time of Newton and Galileo, the tools for capturing and communicating science have remained conceptually unchanged — in essence, they consist of observations on paper (or electronic variants), followed by a ‘letter’ to the community t
Autor:
Jeremiah J Faith, Boris Hayete, Joshua T Thaden, Ilaria Mogno, Jamey Wierzbowski, Guillaume Cottarel, Simon Kasif, James J Collins, Timothy S Gardner
Publikováno v:
PLoS Biology, Vol 5, Iss 1, p e8 (2007)
Machine learning approaches offer the potential to systematically identify transcriptional regulatory interactions from a compendium of microarray expression profiles. However, experimental validation of the performance of these methods at the genome
Externí odkaz:
https://doaj.org/article/b40650686e80437d976f9cfa7dd4bfa8
Autor:
Antonius J. A. van Maris, Timothy S. Gardner, Jack Morel, Laura D. Jennings-Antipov, Robert Mans, Jack T. Pronk, Hannes Juergens, Matthijs S. Niemeijer
Publikováno v:
Scientific Data
Scientific Data, 5
Scientific Data, 5
Open data in science requires precise definition of experimental procedures used in data generation, but traditional practices for sharing protocols and data cannot provide the required data contextualization. Here, we explore implementation, in an a
Autor:
Madhukar S. Dasika, Paul W. Hill, Savita Ganesan, Robert Mans, Kirsten R. Benjamin, Eugene Antipov, Jacob R. Lenihan, Diana Eng, Lan Xu, Hanxiao Jiang, Annie Ening Tsong, Abhishek Murarka, Lishan Zhao, Robert H. Dahl, Jefferson Lai, Lily Chao, Lauren Raetz, Kristy Michelle Hawkins, Poonam R. Saija, Yoseph Tsegaye, Chi-Li Liu, Christopher D. Reeves, Darren Platt, Gale Wichmann, Youngnyun Kim, Jared W. Wenger, Tina Mahatdejkul-Meadows, Joshua S. Leng, Victor F. Holmes, Adam L. Meadows, Patrick J. Westfall, Timothy S. Gardner, Peter K. Jackson, Anna Tai
Publikováno v:
Nature. 537(7622)
Yeast central carbon metabolism has been engineered to achieve a more efficient isoprenoid biosynthesis pathway, an advance that brings commodity-scale production of such compounds a step closer. These authors have re-engineered the central carbon me
Publikováno v:
Journal of Bacteriology. 192:2557-2568
The LasR/LasI quorum-sensing system in Pseudomonas aeruginosa influences global gene expression and mediates pathogenesis. In this study, we show that the quorum-sensing system activates, via the transcriptional regulator PA4778 , a copper resistance
Autor:
Konstantinos T. Konstantinidis, Wenjie Song, Frank Juhn, Mandy J. Ward, Timothy S. Gardner, Daniel Q. Naiman
Publikováno v:
FEMS Microbiology Letters. 283:223-230
An iterative position-specific score matrix (PSSM)-based approach was used to predict σ28 promoters in 11 Shewanella genomes. The Shewanella Correlation Browser was used to distinguish true-positive predictions from false-positive predictions in She
Autor:
Jeremiah J. Faith, Elissa J. Cosgrove, Frank Juhn, Boris Hayete, Stephen J. Schneider, Michael E. Driscoll, Timothy S. Gardner, Vincent A. Fusaro
Publikováno v:
Nucleic Acids Research
Many Microbe Microarrays Database (M3D) is designed to facilitate the analysis and visualization of expression data in compendia compiled from multiple laboratories. M3D contains over a thousand Affymetrix microarrays for Escherichia coli, Saccharomy
Autor:
Timothy S. Gardner, Heming Xing
Publikováno v:
Nature Protocols. 1:2551-2554
This protocol details the use of the mode-of-action by network identification (MNI) algorithm to identify the gene targets of a drug treatment based on gene-expression data. Investigators might also use the MNI algorithm to identify the gene mediator
Publikováno v:
Journal of Process Control. 16:303-311
Cells efficiently carry out organic synthesis, energy transduction, and signal processing across a range of environmental conditions and at nanometer scales—rivaling any engineered system. In the cell, these processes are orchestrated by gene netwo
Autor:
Sarah E. Chobot, James J. Collins, Erin L. Eastwood, Sean Elliott, Scott E. Schaus, Andrew P. Wojtovich, Diego di Bernardo, Timothy S. Gardner, Michael Thompson
Publikováno v:
Nature Biotechnology. 23:377-383
A major challenge in drug discovery is to distinguish the molecular targets of a bioactive compound from the hundreds to thousands of additional gene products that respond indirectly to changes in the activity of the targets1,2,3,4,5,6,7,8. Here, we