Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Timothy S. Charlebois"'
Publikováno v:
Handbook of Validation in Pharmaceutical Processes ISBN: 9781003163138
Handbook of Validation in Pharmaceutical Processes
Handbook of Validation in Pharmaceutical Processes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::327c368a36727d7f7dfb51c095f7eed5
https://doi.org/10.1201/9781003163138-37
https://doi.org/10.1201/9781003163138-37
Autor:
Lisa Connell-Crowley, Kelley C. Rogers, Allison Haug, Eric Fallon, David Pollard, Mark Brower, Maen Qadan, Jason Walther, Ciaran Brady, Timothy S. Charlebois, Michael Coolbaugh, Christopher Gillespie, Kelvin H. Lee, Ruben G. Carbonell, Gene Schaefer, Jeffrey Baker, Roger Hart, Michael A. Phillips, John Erickson, Jon Coffman, Irina Ramos, Eric Garr, Shawn Barrett, Gregg Nyberg
Publikováno v:
Biotechnology and Bioengineering
An ambitious 10‐year collaborative program is described to invent, design, demonstrate, and support commercialization of integrated biopharmaceutical manufacturing technology intended to transform the industry. Our goal is to enable improved contro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f98ba4298af0d2a639f521f0bd8c493b
https://pubmed.ncbi.nlm.nih.gov/33480041
https://pubmed.ncbi.nlm.nih.gov/33480041
Autor:
Linda Francullo, Martin S. Sinacore, Mark Melville, Paula Meleady, Timothy S. Charlebois, Padraig Doolan, Michael Henry, Mark Leonard, Martin Clynes, Patrick Gammell
Publikováno v:
PROTEOMICS. 8:2611-2624
Chinese hamster ovary (CHO) cells are widely used for the production of recombinant protein biopharmaceuticals. The purpose of this study was to investigate differences in the proteome of CHO DUKX cells expressing recombinant human bone morphogenetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31e97c542a3ddc1d10b70f0c41119494
https://doi.org/10.1002/pmic.200700854
https://doi.org/10.1002/pmic.200700854
Autor:
H Brink-Nilsson, B.D Kelley, B Eriksson, S. R. Adamson, B.D O'Connell, Timothy S. Charlebois, M Jernberg
Publikováno v:
Seminars in Hematology. 38:32-39
The possible transmission of blood-borne pathogens has been the impetus behind the development of recombinant products formulated in the absence of human-derived components. The viral safety of Chinese hamster ovary (CHO)-cell-based pharmaceuticals i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d21d6ba89b1410491553ef6b3fc113
https://doi.org/10.1053/shem.2001.25891
https://doi.org/10.1053/shem.2001.25891
Autor:
E Lindner-Olsson, B.D Kelley, C Fenge, Timothy S. Charlebois, Å Ljungqvist, A.-L Smeds, J Rosenquist, Mark Leonard, C Ljungqvist, R.K Eriksson, A Östlin
Publikováno v:
Seminars in Hematology. 38:24-31
The development of a cell bank used in the routine manufacturing of a B-domain deleted recombinant coagulation factor VIII (BDDrFVIII) molecule involved stable insertion of the human BDDrFVIII gene into Chinese hamster ovary (CHO) cells, selection of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::867771a1e934916059bf10a418d94136
https://doi.org/10.1053/shem.2001.25890
https://doi.org/10.1053/shem.2001.25890
Development and characterization of a Chinese hamster ovary cell-specific oligonucleotide microarray
Autor:
Louane E. Hann, Mark Melville, Mark Leonard, Martin Clynes, Padraig Doolan, William M. Mounts, Timothy S. Charlebois, Niall Barron
Publikováno v:
Biotechnology letters. 33(9)
The Chinese hamster ovary (CHO) cell line is one of the most widely used mammalian cell lines for biopharmaceutical production. We have developed and characterized a gene expression microarray (WyeHamster2a) specific for CHO cells that has enabled th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e2c606c653c420bcf703413488398a
https://pubmed.ncbi.nlm.nih.gov/21547514
https://pubmed.ncbi.nlm.nih.gov/21547514
Autor:
Niall Barron, Martin S. Sinacore, Kevin M. McCarthy, Padraig Doolan, Michael Henry, Martin Clynes, Ross Gallagher, Patrick Gammell, Paula Meleady, Mark Melville, Timothy S. Charlebois, Mark Leonard
Publikováno v:
Biotechnology and bioengineering. 106(1)
A high rate of cell growth (micro) leading to rapid accumulation of viable biomass is a desirable phenotype during scale up operations and the early stages of production cultures. In order to identify genes and proteins that contribute to higher grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14f2aa3fa13ff7d8b2a27025eac7d620
https://pubmed.ncbi.nlm.nih.gov/20091739
https://pubmed.ncbi.nlm.nih.gov/20091739
Autor:
Timothy S. Charlebois, Martin S. Sinacore, Dana Di Nino, Gene W. Lee, Niall Barron, Steven I. Max, Kathleen Kopycinski, Mark Leonard, Karin Anderson, Mark Melville, Padraig Doolan, Martin Clynes, Patrick Gammell, Paula Meleady, Kevin M. McCarthy
Publikováno v:
Cells and Culture ISBN: 9789048134182
We have previously reported on the development and use of a proprietary CHO-specific microarray and proteomics technology platforms to interrogate large and diverse sets of CHO cell samples, which embodied several industrially relevant phenotypes. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc5552215d736cea533e8730a88bb2d8
https://doi.org/10.1007/978-90-481-3419-9_72
https://doi.org/10.1007/978-90-481-3419-9_72
Autor:
Paula Meleady, Timothy S. Charlebois, Martin Clynes, Patrick Gammell, Kevin M. McCarthy, Martin S. Sinacore, Padraig Doolan, Linda Francullo, Mark Melville, Mark Leonard
Publikováno v:
Molecular biotechnology. 39(3)
Chinese hamster ovary (CHO) cells are widely used in the biopharmaceutical industry for the production of recombinant human proteins including complex polypeptides such as recombinant human bone morphogenic protein 2 (rhBMP-2). Large-scale manufactur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47531568dec5426dad4a9c3ed0fb0fc8
https://pubmed.ncbi.nlm.nih.gov/18240028
https://pubmed.ncbi.nlm.nih.gov/18240028
Autor:
S. Robert Adamson, Mark Leonard, Timothy S. Charlebois, Martin S. Sinacore, Scott Harrison, Denis Drapeau
Publikováno v:
Encyclopedia of Industrial Biotechnology ISBN: 9780471799306
Encyclopedia of Industrial Biotechnology
Encyclopedia of Industrial Biotechnology
Factors that Affect Genetic Stability of Endogenous Genes Oncogenic Transformation, Aneuploidy, and Genetic Stability Molecular Regulation of Genetic Stablity Genotypic and Phenotypic Stability of Recombinant Cell Lines Stable Integration of Heterolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::505cfe19af48f7db7067a8b38800b4c6
https://doi.org/10.1002/0471250570.spi044
https://doi.org/10.1002/0471250570.spi044