Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Timothy S Jarvela"'
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0241161 (2021)
Alpha-synuclein pre-formed fibrils (PFFs) represent a promising model system for the study of cellular processes underlying cell-to-cell transmission of alpha-synuclein proteopathic aggregates. However, the ability to differentiate the fate of intern
Externí odkaz:
https://doaj.org/article/4452e22d31c74a0291550787dbd1036b
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
Protein homeostasis, or proteostasis, is a combination of cellular processes that govern protein quality control, namely, protein translation, folding, processing, and degradation. Disruptions in these processes can lead to protein misfolding and agg
Externí odkaz:
https://doaj.org/article/f9a7df1afac049fcbbdc882fa918c758
Autor:
Juan R. Peinado, Kriti Chaplot, Timothy S. Jarvela, Edward M. Barbieri, James Shorter, Iris Lindberg
Publikováno v:
ACS Chem Neurosci
As neurons age, protein homeostasis becomes less efficient, resulting in misfolding and aggregation. Chaperone proteins perform vital functions in the maintenance of cellular proteostasis, and chaperone-based therapies that promote sequestration of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c31f44f2ea11339d1d9543e2be63c7c
https://doi.org/10.1021/acschemneuro.2c00156
https://doi.org/10.1021/acschemneuro.2c00156
Autor:
Hitoshi Iida, Tatsuyoshi Kono, Chih-Chun Lee, Preethi Krishnan, Matthew C. Arvin, Staci A. Weaver, Timothy S. Jarvela, Robert N. Bone, Xin Tong, Peter Arvan, Iris Lindberg, Carmella Evans-Molina
Increased circulating levels of incompletely processed insulin (i.e. proinsulin) are observed clinically in both type 1 and type 2 diabetes; however, the mechanisms underlying impaired proinsulin processing remain incompletely understood. Here, we id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4650c5d2e43900ce537422c5527ef5b1
https://doi.org/10.1101/2022.06.13.495980
https://doi.org/10.1101/2022.06.13.495980
Publikováno v:
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Vol 12 (2020)
Frontiers in Aging Neuroscience, Vol 12 (2020)
Protein homeostasis, or proteostasis, is a combination of cellular processes that govern protein quality control, namely, protein translation, folding, processing, and degradation. Disruptions in these processes can lead to protein misfolding and agg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81af9364efb3068b0c1c3fc9c5d9bfc7
https://pubmed.ncbi.nlm.nih.gov/33192447
https://pubmed.ncbi.nlm.nih.gov/33192447
Autor:
Tatsuyoshi Kono, Peter Arvan, Xin Tong, Carmella Evans-Molina, Iris Lindberg, Timothy S. Jarvela, Hitoshi Iida, Chih-Chun Lee
Publikováno v:
Diabetes. 69
Impaired proinsulin processing is observed in both type 1 and type 2 diabetes. We have previously shown that reductions in endoplasmic reticulum (ER) calcium (Ca2+) in the pancreatic β cell arising from impaired activity of the Sarcoendoplasmic Reti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c05d8a8a4199e8a134a3fefece25da9
https://doi.org/10.2337/db20-48-or
https://doi.org/10.2337/db20-48-or
Autor:
Juan R. Peinado, Edward M. Barbieri, Timothy S. Jarvela, Kriti Chaplot, James Shorter, Iris Lindberg
As neurons age, protein homeostasis becomes less efficient, resulting in misfolding and aggregation. Chaperone proteins perform vital functions in the maintenance of cellular proteostasis, and chaperone-based therapies that promote sequestration of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ba4b53e4f74ddd8bec5d67c4ce519bb
https://doi.org/10.1101/2020.04.15.039578
https://doi.org/10.1101/2020.04.15.039578
Autor:
Timothy S. Jarvela, Laura M. Yerges-Armstrong, Alexandra H. Winters, Bruno Ramos-Molina, Iris Lindberg, Toni I. Pollin
Publikováno v:
Diabetes Research and Clinical Practice. 131:82-90
Aims In humans, noncoding variants of PCSK2, the gene encoding prohormone convertase 2 (PC2), have been previously associated with risk for and age of onset of type 2 diabetes (T2D). The aims of this study were to identify coding variants in PCSK2; t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cd348c1e97235284a48727d8eefb6fa
https://doi.org/10.1016/j.diabres.2017.06.023
https://doi.org/10.1016/j.diabres.2017.06.023
Autor:
Timothy S Jarvela, Surbhi Gahlot, Manita Shakya, Tomas Bachor, Anne White, Malcolm J Low, Iris Lindberg
Publikováno v:
Endocrinology
Common mutations in the human prohormone convertase 1/3 (PC1/3) gene (PCSK1) are linked to increased risk of obesity. Previous work has shown that the rs6232 SNP (N221D) results in slightly decreased activity, though whether this decrease underlies o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2249362ea67e85d56e01d1a5cb3d7843
https://doi.org/10.1210/en.2019-00418
https://doi.org/10.1210/en.2019-00418
Autor:
Tasha Womack, Polymnia Georgiou, Todd D. Gould, Iris Lindberg, Jason L. Eriksen, Timothy S. Jarvela
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Impairment of neuronal proteostasis is a hallmark of Alzheimer’s and other neurodegenerative diseases. However, the underlying molecular mechanisms leading to pathogenic protein aggregation, and the role of secretory chaperone proteins in this proc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db1941da8282aac744fa3fa541869a9
https://pubmed.ncbi.nlm.nih.gov/29955078
https://pubmed.ncbi.nlm.nih.gov/29955078