Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Timothy S Choi"'
Autor:
Mingye Feng, Kristopher D. Marjon, Fangfang Zhu, Rachel Weissman-Tsukamoto, Aaron Levett, Katie Sullivan, Kevin S. Kao, Maxim Markovic, Paul A. Bump, Hannah M. Jackson, Timothy S. Choi, Jing Chen, Allison M. Banuelos, Jie Liu, Phung Gip, Lei Cheng, Denong Wang, Irving L. Weissman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Macrophage-mediated programmed cell removal (PrCR) allows clearance of living cells. Here the authors show that, in mouse models, activated macrophages create an “eat me” signal via calreticulin secretion on neutrophils during peritonitis and on
Externí odkaz:
https://doaj.org/article/a1b68cf0ddc143208c23a7ee9e16b82a
Autor:
James Yuhtyng Chen, Lisa Johnson, Kelly Marie McKenna, Timothy S. Choi, Jiaqi Duan, Dongdong Feng, Jonathan M. Tsai, Natalia Garcia-Martin, Kavitha Sompalli, Roy Maute, Paresh Vyas, Ravindra Majeti, Chris H.M. Takimoto, Jie Liu, Giridharan Ramsingh, Mark Chao, Jens-Peter Volkmer, Irving L. Weissman
Publikováno v:
Journal of Clinical Oncology. 40:7054-7054
7054 Background: Magrolimab is a monoclonal antibody that blocks CD47, a “don’t eat me” signal expressed on cancer cells to escape immune surveillance and macrophage-mediated clearance. Prior preclinical studies have shown that CD47 is critical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d5133aebc755b5fb82e240beb136c9e
https://doi.org/10.1200/jco.2022.40.16_suppl.7054
https://doi.org/10.1200/jco.2022.40.16_suppl.7054
Autor:
Jie Liu, Shirley Mihardja, Irving L. Weissman, Ravindra Majeti, Jens-Peter Volkmer, Balaji Agoram, Kavitha Sompalli, Sharline Chen, Seethu Xavy, Timothy S Choi, Dongdong Feng
Publikováno v:
JCI Insight
The CD47/signal regulatory protein α (Cd47/SIRPα)interaction provides a macrophage immune checkpoint pathway that plays a critical role in cancer immune evasion across multiple cancers. Here, we report the engineering of a humanized anti-SIRPα mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d47165cdac3a638bd37ce609e8658616
https://pubmed.ncbi.nlm.nih.gov/32427583
https://pubmed.ncbi.nlm.nih.gov/32427583
Autor:
Jie Liu, Sharline Chen, Cynthia E. Dunbar, Irving L. Weissman, James Y. Chen, Balaji Agoram, Ravi Majeti, Kristopher D. Marjon, Chris H. Takimoto, Jiaqi Duan, Kavitha Sompalli, Timothy S Choi, Mark P. Chao, Mwe Mwe Chao, Jens-Peter Volkmer, Leslie S. Kean, Dongdong Feng, Ofelia Mata
Publikováno v:
Blood. 134:4428-4428
Background Hematopoietic stem cell (HSC) transplantation (HSCT) is a well-established procedure that, with or without gene therapy, is curative for numerous severe life-threatening diseases including genetic blood disorders and blood cancers. While a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6d0338b3c1afd26f43376e14b6cb47e
https://doi.org/10.1182/blood-2019-131490
https://doi.org/10.1182/blood-2019-131490
Autor:
Mark P. Chao, Timothy S Choi, Roy Louis Maute, Jens-Peter Volkmer, Kristopher D. Marjon, James Y. Chen, Balaji Agoram, Chris H. Takimoto, Jiaqi Duan
Publikováno v:
Blood. 134:5229-5229
Introduction Magrolimab (Hu5F9-G4, 5F9) is a first-in-class IgG4 antibody targeting CD47, a macrophage immune checkpoint and "don't eat me" signal expressed on cancer cells. Blockade of CD47 leads to phagocytosis of tumor cells. Magrolimab synergizes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f041b9451b73d21562d7bbd5f34df86
https://doi.org/10.1182/blood-2019-127526
https://doi.org/10.1182/blood-2019-127526
Autor:
Chris H. Takimoto, Jiaqi Duan, Kavitha Sompalli, Mark P. Chao, Timothy S Choi, Lynette Brown, Kyle Elrod, Ravindra Majeti, Jie Liu, Jennifer J. Stewart, Jens-Peter Volkmer, Mckenna Kelly Marie, James Y. Chen, Stanley L. Schrier, Paresh Vyas, Irving L. Weissman
Publikováno v:
Blood. 132:2327-2327
CD47 is an anti-phagocytic (i.e. "don't eat me") signal and macrophage checkpoint that cancer cells utilize to evade innate immunity and establish disease. 5F9 is a humanized IgG4 monoclonal antibody (mAb) that binds to human CD47 and blocks its inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::044676e0c2b624d2e5c1edb1297879e3
https://doi.org/10.1182/blood-2018-99-115674
https://doi.org/10.1182/blood-2018-99-115674