Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Timothy S Chisholm"'
Publikováno v:
Chemical Science
The development of an iterative one-pot peptide ligation strategy is described that capitalises on the rapid and efficient nature of the diselenide–selenoester ligation reaction, together with photodeselenisation chemistry. This ligation strategy h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9199ca030619c70991067f05b7120f91
http://europepmc.org/articles/PMC8317654
http://europepmc.org/articles/PMC8317654
Autor:
David Klenerman, Timothy S. Chisholm, Franklin I. Aigbirhio, Christopher A. Hunter, Elena Sanna, Margarida Rodrigues, Steven G. Fagan, Maria Grazia Spillantini, Klara Kulenkampff
Publikováno v:
Chemical Science
A key process in the development of neurodegenerative diseases such as Alzheimer's and Parkinson's diseases is the aggregation of proteins to produce fibrillary aggregates with a cross β-sheet structure, amyloid. The development of reagents that can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0069553a83a6b7830d73d6c5397db40c
https://www.repository.cam.ac.uk/handle/1810/326792
https://www.repository.cam.ac.uk/handle/1810/326792
Publikováno v:
Journal of the American Chemical Society. 140:9020-9024
Native chemical ligation (NCL) combined with desulfurization chemistry has revolutionized the way in which large polypeptides and proteins are accessed by chemical synthesis. Herein, we outline the use of flow chemistry for the ligation-based assembl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64c46ece2fa375a6b33283257c3e579d
https://doi.org/10.1021/jacs.8b03115
https://doi.org/10.1021/jacs.8b03115