Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Timothy Rust"'
Autor:
Timothy Rust, Carla Hassler, James P. Harding, Justin J. Richards, Brian I. Bliss, Yuri L. Khmelnitsky, David D. Manning, Marlene L. Cohen, Liaqat Masih, Michael A. Lynch, Jianqing Chen, Kevin L. Christensen, Zhicai Yang, Soshanna Isaacson, Jonathan D. Wierschke, Cathy M. Beer, Russell J. DeOrazio, Jun-Ho Maeng, Lisa H. Peterson, Christopher L. Cioffi, Alexander Usyatinsky, Kevin Fitzpatrick, David J. Fairfax, Matthew Isherwood, Svetlana Dobritsa, W. Martin Rennells
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6538-6541
A new class of 2-substituted benzoxazole carboxamides are presented as potent functional 5-HT(3) receptor antagonists. The chemical series possesses nanomolar in vitro activity against human 5-HT(3)A receptors. A chemistry optimization program was co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f332105939c77bf627dc617b2e13b623
https://doi.org/10.1016/j.bmcl.2010.09.038
https://doi.org/10.1016/j.bmcl.2010.09.038
Autor:
Sara H. Thrall, Rosalie Matico, Michael Jaye, Paul M. Keller, Benjamin J. Schwartz, Timothy Rust, Dennis J. Murphy, Anthony J. Jurewicz, Krawiec John A, Mark R. Harpel, John J. Trill
Publikováno v:
SLAS Discovery. 13:468-475
Endothelial lipase (EL) is a 482-amino-acid protein from the triglyceride lipase gene family that uses a Ser-His-Asp triad for catalysis. Its expression in endothelial cells and preference for phospholipids rather than triglycerides are unique. Anima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e3ba42867dd6fef670c2bc8755a7082
https://doi.org/10.1177/1087057108319738
https://doi.org/10.1177/1087057108319738