Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Timothy R. Peterson"'
Autor:
Dos D. Sarbassov, David M. Sabatini, Mark A. Magnuson, Steven A. Carr, Hasmik Keshishian, Terri A. Addona, Timothy R. Peterson, Nitin K. Agarwal, Tattym Shaikenov, Chien-Hung Chen, Delphine Boulbes
Supplementary Data from Rictor Phosphorylation on the Thr-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23659829f88e380f269558fffa09aa25
https://doi.org/10.1158/1541-7786.22519155.v1
https://doi.org/10.1158/1541-7786.22519155.v1
Autor:
Dos D. Sarbassov, David M. Sabatini, Mark A. Magnuson, Steven A. Carr, Hasmik Keshishian, Terri A. Addona, Timothy R. Peterson, Nitin K. Agarwal, Tattym Shaikenov, Chien-Hung Chen, Delphine Boulbes
In animal cells, growth factors coordinate cell proliferation and survival by regulating the phosphoinositide 3-kinase/Akt signaling pathway. Deregulation of this signaling pathway is common in a variety of human cancers. The PI3K-dependent signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5107286051fc5b6ea843edffc7b7045
https://doi.org/10.1158/1541-7786.c.6542322.v1
https://doi.org/10.1158/1541-7786.c.6542322.v1
Autor:
Zhou Yu, Lauren E Surface, Chong Yon Park, Max A Horlbeck, Gregory A Wyant, Monther Abu-Remaileh, Timothy R Peterson, David M Sabatini, Jonathan S Weissman, Erin K O'Shea
Publikováno v:
eLife, Vol 7 (2018)
Nitrogen-containing-bisphosphonates (N-BPs) are a class of drugs widely prescribed to treat osteoporosis and other bone-related diseases. Although previous studies have established that N-BPs function by inhibiting the mevalonate pathway in osteoclas
Externí odkaz:
https://doaj.org/article/5fef22a34a86472285b5e7774ff2a709
Autor:
Timothy R. Peterson, Sandeep Kumar
Publikováno v:
Nutrition and Healthy Aging
As the global population ages, there is increased interest in living longer and improving one’s quality of life in later years. However, studying aging – the decline in body function – is expensive and time-consuming. And despite research succe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba88d119cb5262838f8e57c19093e661
https://doi.org/10.3233/nha-190064
https://doi.org/10.3233/nha-190064
Autor:
Christopher M. McAndrew, Zhou Yu, Steven Mumm, Kathryn Diemer, Michael J. Gardner, Gabe Haller, Fei Wan, Melissa Sum, Yangjin Bae, Lauren E. Surface, Niki Song, Shenghui Duan, William M Ricci, Thijn R. Brummelkamp, Timothy R. Peterson, Noopur Raje, Margaret Huskey, Daniel A. Haber, Kristen M. Shannon, Sandeep Kumar, Christina L. Costantino, Jinmei Li, Jan E. Carette, Brendan Lee, Mahshid Mohseni, Jiwoong Park, Abbhirami Rajagopal, Damon T. Burrow, Malini Varadarajan, Kıvanç Birsoy, Jonathan C. Baker, Thomas B. Dodson, Charles Gu, Vinieth N. Bijanki, Cheng Lyu, Christina A. Gurnett, David M. Sabatini, Roberto Civitelli
Publikováno v:
PMC
Nitrogen-containing bisphosphonates (N-BPs), such as alendronate, are the most widely prescribed medications for diseases involving bone, with nearly 200 million prescriptions written annually. Recently, widespread use of N-BPs has been challenged du
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2223613b886c4d52ad1ac9e7f0821f2
https://doi.org/10.1126/scitranslmed.aav9166
https://doi.org/10.1126/scitranslmed.aav9166
Autor:
Anastasiia Pendergrass, Thijn R. Brummelkamp, India C Bradley, Jiwoong Park, Niki Song, Nicholas L Bean, Jinmei Li, Sandeep Kumar, Nicholas C Jacobs, Ariella Coler-Reilly, Roland E. Dolle, Damon T. Burrow, Malini Varadarajan, Timothy R. Peterson, Tanya H Pierre, Jan E. Carette, Sydney K Hart
Chloroquine is an anti-malarial and immunosuppressant drug that has cationic amphipathic chemical properties. We performed genome-wide screens in human cells with chloroquine and several other widely used cationic amphipathic drugs (CADs) including t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072420f8c7d34ecdaba1d0254430ac42
https://doi.org/10.1101/2020.04.10.035683
https://doi.org/10.1101/2020.04.10.035683
Moore’s law states that computers get faster and less expensive over time. In contrast in biopharma, there is the reverse spelling, Eroom’s law, which states that drug discovery is getting slower and costing more money every year. Herein, we prop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::463e6f4f65459ba03b0f2fcba29e61cb
https://doi.org/10.1101/487157
https://doi.org/10.1101/487157
Autor:
Ginger E. Nicol, Y. Zhong, Michael D. Yingling, Daniel J. Müller, John W. Newcomer, Charles F. Reynolds, Benoit H. Mulsant, Timothy R. Peterson, Adam E. Locke, J. P Miller, Eric J. Lenze, Hanadi Ajam Oughli
Publikováno v:
J Psychiatr Res
Introduction All atypical antipsychotics are associated with some degree of weight gain. We applied a novel statistical approach to identify moderators of aripiprazole-induced fat gain using clinical and genetic data from a randomized clinical trial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6122821d73f394a13cb5735ae30591b9
https://pubmed.ncbi.nlm.nih.gov/31039482
https://pubmed.ncbi.nlm.nih.gov/31039482
Autor:
Timothy R. Peterson, Britt Adamson, Albert Xu, Max A. Horlbeck, Chong Y. Park, Min Wang, Martin Kampmann, Derek Bogdanoff, Michael A. Fischbach, Luke A. Gilbert, Eric D. Chow, Jonathan S. Weissman, Neal K. Bennett, Ken Nakamura
Publikováno v:
Cell, vol 174, iss 4
Seminal yeast studies have established the value of comprehensively mapping genetic interactions (GIs) for inferring gene function. Efforts in human cells using focused gene sets underscore the utility of this approach, but the feasibility of generat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef508865dc1e6d781cdb08070b5895fa
https://escholarship.org/uc/item/5h43185t
https://escholarship.org/uc/item/5h43185t
Autor:
Chong Yon Park, Zhou Yu, Timothy R. Peterson, Lauren E. Surface, Erin K. O'Shea, Monther Abu-Remaileh, Max A. Horlbeck, Gregory A. Wyant, David M. Sabatini, Jonathan S. Weissman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ee9d084b1702586687084344707e98e
https://doi.org/10.7554/elife.36620.020
https://doi.org/10.7554/elife.36620.020