Zobrazeno 1 - 10 of 94 pro vyhledávání: '"Timothy R. Orchard"'
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Akademický článek
Effects of bowel preparation on intestinal bacterial associated urine and faecal metabolites and the associated faecal microbiome
Autor: Sam T. R. Powles, Kate I. Gallagher, Leo W. L. Chong, James L. Alexander, Benjamin H. Mullish, Lucy C. Hicks, Julie A. K. McDonald, Julian R. Marchesi, Horace R. T. Williams, Timothy R. Orchard
Publikováno v: BMC Gastroenterology, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background Urinary and faecal metabolic profiling have been extensively studied in gastrointestinal diseases as potential diagnostic markers, and to enhance our understanding of the intestinal microbiome in the pathogenesis these conditions.
Externí odkaz: https://doaj.org/article/bd479af395644bdb902270d2ec762c46
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HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease
Autor: Timothy R. Orchard, Rosemary H Phillips, Stephen M. Evans, Arvind Ramadas, Paul R. Banim, Guy Chung-Faye, Subramaniam Ramakrishnan, Simon Panter, Leonie Grellier, Hasnain Jafferbhoy, Nigel Trudgill, Thankam Paul, Sian Kirkham, Anna J Pigott, M J Carter, Juan De La Revella Negro, Lisa Gervais, Zia Mazhar, Suranga Dharmisari, Richard A. Miller, Cathryn Preston, Alison Simmons, Rachel Cooney, Natalie C. Direkze, Deb Ghosh, Christian P. Selinger, Andrew A. Fagbemi, Rakesh Chaudhary, J R Fraser Cummings, Stephen Gore, James O. Lindsay, Tony C.K. Tham, David Hobday, Charles Murray, David Watts, Anne Willmott, Gill Watts, Sandip Sen, Mark Reppell, Amer Azaz, Shaji Sebastian, Neil Chanchlani, R B Johnston, Ben Hope, Salil Singh, Stephen Foley, Sunil Sonwalkar, Jonathon Snook, Lawrence Armstrong, Amanda Beale, Andy Li, Tariq Mahmood, Stephen Lewis, Kevin J. Monahan, Timothy J. McDonald, Gareth T. Jones, John N. Gordon, Nicholas A Kennedy, Sheldon C. Cooper, Gareth J. Walker, James W Hart, Sarah Langlands, Carl A. Anderson, Marcus Harbord, Alistair McNair, Achuth Shenoy, Graham A. Heap, Radhakrishnan Hariraj, Mandy H Perry, Charlie Lees, Shanika de Silva, Christopher J. Hawkey, Loukas Moutsianas, Matthew J Brookes, Christos Tzivinikos, Veena Zamvar, Cathryn Edwards, Claire Bell, Rebecca Saich, Peter M. Irving, Mark S. Smith, Phillip Mayhead, Christopher Macdonald, Dharamveer Basude, Andrew T. Cole, Ailsa Hart, Daniel R. Gaya, Kasamu Dawa Kabiru, Assad Butt, John C Mansfield, John Beckly, Anton V J Gunasekera, Simon Lal, Charles Pj Charlton, Astor Rodrigues, Craig Mowat, Joel Mawdsley, Palani Sathish Babu, John C. Mansfield, Mary-Anne Morris, Senthil V. Murugesan, Dermot P.B. McGovern, Richard Pollok, Franco Torrente, Jeffrey C. Barrett, Aleksejs Sazonovs, Aminda De Silva, George MacFaul, Paul Dunckley, Neeraj Prasad, Zahid Mahmood, Neil P. Shah, Richard Shenderey, Tariq Iqbal, Anjan Dhar, Bruce McLain, James R Goodhand, Anita Modi, Daniel L. Rice, Patrick Goggin, Alka Thakur, Vinod B. Patel, Vishal Kaushik, Scott Levison, Sonia Bouri, Fraser Cummings, Emma Wesley, Anurag Agrawal, Deven Vani, Jimmy K. Limdi, Miles Parkes, David A Elphick, Mark Tighe, Nicholas M. Croft, Charlie W. Lees, Helen Matthews, B K Baburajan, Andrew Bell, Melissa A. Smith, Tariq Ahmad, Stephen Bridger, Mark Tremelling, Matthew W. Johnson, John Fell, Claire Bewshea, Bim Bhaduri, Julie Doherty, Sean Weaver, Ben Colleypriest, Chuka U. Nwokolo, John de Caestecker, Richard K. Russell, Stuart Bloom
Publikováno v: 2020, ' HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease ', Gastroenterology, vol. 158, no. 1, pp. 189-199 . https://doi.org/10.1053/j.gastro.2019.09.041
BACKGROUND & AIMS: Anti-tumor necrosis factor (anti-TNF) therapies are the most widely used biologic drugs for treating immune-mediated diseases, but repeated administration can induce the formation of anti-drug antibodies. The ability to identify pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24124ba5a4463940336ceef1408fceec
https://hdl.handle.net/20.500.11820/48abbae6-a739-4da4-9ca4-88c2ccd14323
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3
PTH-122 Faecal calprotectinsuggests presence of gut inflammation in axial spondyloarthritis without IBD
Autor: Timothy R. Orchard, Andrew Keat, Julian Marchesi, Horace R T Williams, Julie A. K. McDonald, Uma Selvarajah, Jesus Miguens Blanco, Shiva T. Radhakrishnan, Alex Pechlivanis, Pedro Machado, Sam T. Powles
Publikováno v: Posters.
Studies since early 1980s have shown the presence of subclinical gut inflammation in up to 60% of the patients with axial spondyloarthritis, 6% of which proceed to become inflammatory bowel disease (IBD) in 10 years. Here we aim to further explore th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::85cc7d5b05d6caee23d5007fba631748
https://doi.org/10.1136/gutjnl-2019-bsgabstracts.181
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4
PTH-123 Is axial spondyloarthritis in IBD different to axial spondyloarthritis without IBD?
Autor: Andrew Keat, Uma Selvarajah, Jesus Miguens Blanco, Timothy R. Orchard, Shiva T. Radhakrishnan, Alex Pechlivanis, Julian Marchesi, Horace R T Williams, Julie A. K. McDonald, Sam T. Powles, Pedro Machado
Publikováno v: Posters.
Up to 40% of the patients with inflammatory bowel disease (IBD) have MRI evidence of axial spondyloarthritis compared to 1.5% in the non IBD population. Here we aim to distinguish axial spondyloarthritis associated with IBD (axSpA-IBD) from axSpA wit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f8dfbff7db3c4e574d0b9f601ea71df
https://doi.org/10.1136/gutjnl-2019-bsgabstracts.182
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5
PTH-113 Effect of ethnicity on the faecal water metabolic profiles in crohn’s disease
Autor: Elaine Holmes, Lucy C. Hicks, Sam T. Powles, Horace R T Williams, Jonathan R. Swann, Leo W Chong, Timothy R. Orchard, Kate Gallagher
Publikováno v: Posters.
Introduction South Asians (SA) with Crohn’s disease (CD) display a different disease phenotype and course (Walker, 2011. AJG.), as well as a different urinary metabolic profile (Marchesi, 2008. J. Proteome Res.). Metabolic profiling of faecal water
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::606116e03e0e497e16cc8752478514fe
https://doi.org/10.1136/gutjnl-2019-bsgabstracts.172
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7
P663 Long-term follow up in IBD: 10-year observational study of a UK IBD cohort
Autor: A Vasireddy, Timothy R. Orchard, S Peake, H Williams, Lucy C. Hicks, Shiva T. Radhakrishnan, Sam T. Powles, Leo W Chong, Kate Gallagher
Publikováno v: Journal of Crohn's and Colitis. 15:S588-S588
Background Crohn’s Disease (CD) and ulcerative colitis (UC) are the two main sub-types of Inflammatory Bowel disease (IBD), which affect 300–500 per 100,000 people within Europe, with an increasing incidence. Long-term outcomes have been reported
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e6d8a5125f34d83c6ddc9da1582ff086
https://doi.org/10.1093/ecco-jcc/jjab076.783
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Role of 18F-fluorodeoxyglucose Positron Emission Tomography in the Monitoring of Inflammatory Activity in Crohnʼs Disease
Autor: Ryan Janisch, Timothy R. Orchard, Sameer Khan, Paul M. Matthews, Roger N. Gunn, Evangelos Russo, Stuart A. Taylor, Eugenii A. Rabiner
Publikováno v: Inflammatory Bowel Diseases. 22:2619-2629
BACKGROUND: 18Fluorine-fluorodeoxyglucose positron emission tomography (18F-FDG PET) has recently attracted interest for the measurement of disease activity in Crohn's disease (CD). The aim of this study was to assess the utility of FDG-PET as a mark
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0df2f8ef16ddff05dbe3c82739dec1e
https://doi.org/10.1097/mib.0000000000000924
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9
Magnetic resonance imaging-quantified small bowel motility is a sensitive marker of response to medical therapy in Crohn's disease
Autor: Evangelos Russo, Timothy R. Orchard, Gauraang Bhatnagar, Stuart A. Taylor, Alex Menys, Steve Halligan, R. Vega, Davide Prezzi, Andrew Plumb
Publikováno v: Europe PubMed Central
Magnetic resonance enterography (MRE) can measure small bowel motility, reduction in which reflects inflammatory burden in Crohn's Disease (CD). However, it is unknown if motility improves with successful treatment.To determine if changes in segmenta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1557c1ad4836e1fb7fdb529da1365c7
https://doi.org/10.1111/apt.13275
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10
Diarrhea in Crohn’s Disease: Investigating the Role of the Ileal Hormone Fibroblast Growth Factor 19
Autor: Timothy R. Orchard, Jonathan D. Nolan, Ian M. Johnston, Sanjeev S. Pattni, Tracy Dew, Julian R.F. Walters
Publikováno v: Journal of Crohn's and Colitis. 9:125-131
Background: Bile acids [BA] are usually reabsorbed by the terminal ileum, but this process is frequently abnormal in Crohn’s disease [CD]. BA malabsorption occurs, and excess colonic BA cause secretory diarrhea. Furthermore, the hormone fibroblast
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a98dd3b314bb47fd43893eb58ba9aae
https://doi.org/10.1093/ecco-jcc/jju022
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